Abstract
Polymeric dental resin materials are known to leach cytotoxic unreacted monomers and degradation products. In this study, methacrylic derivatives of bile acids have been synthesized for use as monomers in dental composites, their in vitro cytotoxicity and bile acids toward NIH3T3 fibroblasts has been evaluated by colorimetric MTT assay and compared with that of the common dental monomers BisGMA and TEGDMA. The results show that bile acids and their derivatives can induce mitochondrial dysfunction at similar or higher concentrations than the commercial dental monomers. Certain monomers did not influence colorimetric absorbance in MTT assay against the normal control over their entire range of solubility.
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Financial support from the Science and Technology Project of Tianjin (No. 10JCZDJC22500, ZXCXSY10100) is gratefully acknowledged.
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Hu, X., Zhou, H., Song, G., Liu, A., Wang, L. (2014). In Vitro Cytotoxicity of the Bile Acids and Bile Acid Derivatives. In: Zhang, TC., Ouyang, P., Kaplan, S., Skarnes, B. (eds) Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012). Lecture Notes in Electrical Engineering, vol 251. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37925-3_163
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DOI: https://doi.org/10.1007/978-3-642-37925-3_163
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