Abstract
Pyrrolizinone derivatives were discovered showing remarkable anti-inflammatory and analgesic activities. Based on the SAR summarized before, a series of pyrrolizinone derivatives were designed and synthesized in this paper. All the eight target compounds were characterized by 1HNMR spectra, and the test of anti-inflammatory and analgesic activities is in progress.
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References
Morriello GJ, Chicchi G, Johnson T et al (2010) Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor. Bioorg Med Chem Lett 20(19):5925–5932
Morriello GJ, Mills SG, Johnson T et al (2010) Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists. Bioorg Med Chem Lett 20(6):2007–2012
Despinoy XL, McNab H (2009) 1-Methoxycarbonylpyrrolizin-3-one and related compounds. Org Biomol Chem 7(10):2187–2194
Lescot E, Bureau R, Sopkova-de Oliveira Santos J et al (2005) 3D-QSAR and docking studies of selective GSK-3beta inhibitors. comparison with a thieno[2,3-b]pyrrolizinone derivative, a new potential lead for GSK-3beta ligands. J Chem Inf Model 45(3):708–715
Zhao LQ, Hu YD, Yuan Y et al (2001) Studied on docking of 5,6-diaryl-2,3-dihydro-1-pyrrolizinone derivatives with cyclooxygenase. Yao Xue Xue Bao 36(6):415–418
Zhao LQ, Yuan Y, Hu YD et al 3D-QSAR of antiinflammatory activities of 5,6-diaryl-2,3-dihydro-1-pyrrolizinone derivatives]. Yao Xue Xue Bao. 36(5):343–346
Zhao LQ, Yang Z, Zhang SF (2001) 5, 6-diaryl-2, 3-dihydro-1-pyrrolizinone derivatives synthesis and antiiflammatory and analgesic activities. Yao Xue Xue Bao 36(4):258–261
Zhang SF, Gao WF, Hen HZ (1988) Synthesis of 3H-1, 2-dihydro-1-pyrrolizinone derivatives. Yao Xue Xue Bao 23(1):28–33
Acknowledgments
The authors sincerely thank Professor Peng Yu and his team in the Tianjin University of Science and Technology for the characterization of compounds and other generous help.
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Sun, C., Cao, J. (2014). Design and Synthesis of 1H-2, 3-Dihydro-1-Pyrrolizinones Derivatives. In: Zhang, TC., Ouyang, P., Kaplan, S., Skarnes, B. (eds) Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012). Lecture Notes in Electrical Engineering, vol 250. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37922-2_95
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DOI: https://doi.org/10.1007/978-3-642-37922-2_95
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