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Persistent Pulmonary Hypertension of the Newborn

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PanVascular Medicine

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Abstract

At birth, the fetal cardiopulmonary system rapidly establishes the lung as the organ of gas exchange by decreasing pulmonary vascular resistance (PVR) and increasing pulmonary blood flow. Pulmonary artery pressure and vascular resistance continue to slowly decrease for another 2–3 weeks after birth. The vasoconstrictive response to hypoxia is retained into adulthood, and pulmonary hypertension can be easily triggered in the newborn period by hypoxic lung disease, apnea, or other causes. As development continues through infancy, normal lung function and growth requires maintenance of low pulmonary vascular resistance.

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  1. Department of Pediatrics Administration, University of California Davis Children’s Hospital, 2516 Stockton Blvd 3rd Floor, Sacramento, CA, 95817, USA

    Prof. Robin H. Steinhorn M.D. (Professor and Chair)

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  1. Prof. Robin H. Steinhorn M.D.
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Correspondence to Robin H. Steinhorn M.D. .

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  1. Akademisches Lehrkrankenhaus MLU, Bitterfeld-Wolfen, Germany

    Peter Lanzer

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Steinhorn, R.H. (2014). Persistent Pulmonary Hypertension of the Newborn. In: Lanzer, P. (eds) PanVascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37393-0_157-1

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