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Nutrition, Histone Epigenetic Marks, and Disease

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Environmental Epigenomics in Health and Disease

Part of the book series: Epigenetics and Human Health ((EHH))

Abstract

The dietary intake of essential nutrients and bioactive food compounds is a process that occurs on a daily basis for the entire life span. Therefore, your diet has a great potential to cause changes in the epigenome. Known histone modifications include acetylation, methylation, biotinylation, poly(ADP-ribosylation), ubiquitination, and sumoylation. Some of these modifications depend directly on dietary nutrients. For other modifications, bioactive dietary compounds may alter the activities of enzymes that establish or remove histone marks, thereby altering the epigenome. This chapter provides an overview of diet-dependent epigenomic marks in histones and their links with human health.

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Abbreviations

Avy :

Viable yellow agouti

CoA:

Coenzyme A

DNMT1:

DNA methyltransferase 1

FAD:

Flavin adenine dinucleotide

H3K4me3:

K4-trimethylated histone H3

H3K9ac:

K9-acetylated histone H3

H3K9me2:

K9-dimethylated histone H3

H3K9me3:

K9-trimethylated histone H3

H4K5ac:

K5-acetylated histone H4

H4K8ac:

K8-acetylated histone K12

H4K12ac:

K12-acetylated histone H4

H4K12bio:

K12-biotinylated histone

H4H4K16ac:

K16-acetylated histone H4

H4K20me3:

K20-trimethylated histone H4

HAT:

Histone acetyl transferase

HDAC:

Histone deacetylase

HLCS:

Holocarboxylase synthetase

HMT:

Histone methyl transferase

JmjC:

Jumonji C

K:

Lysine

LSD1:

Lysine-specific demethylase 1

SET:

Suppressor of variegation enhancer of zeste trithorax

Sir2:

Silent information regulator 2

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Acknowledgments

A contribution of the University of Nebraska Agricultural Research Division, supported in part by funds provided through the Hatch Act. Additional support was provided by NIH grants DK063945, DK077816, DK082476 and ES015206, and USDA CSREES grant 2006-35200-17138.

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  1. Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, 316 Ruth Leverton Hall, Lincoln, NE, 68583-0806, USA

    Janos Zempleni, Dandan Liu & Jing Xue

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  1. Janos Zempleni
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  2. Dandan Liu
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  3. Jing Xue
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Correspondence to Janos Zempleni .

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  1. School of Medicine and Public Health, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, University Avenue 1400, Madison, 53706, Wisconsin, USA

    Randy L. Jirtle

  2. National Institute of Environmental Hea, NIEHS, National Institutes of Health, Research Triangle Park, 27709, North Carolina, USA

    Frederick L. Tyson

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Zempleni, J., Liu, D., Xue, J. (2013). Nutrition, Histone Epigenetic Marks, and Disease. In: Jirtle, R., Tyson, F. (eds) Environmental Epigenomics in Health and Disease. Epigenetics and Human Health. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36827-1_9

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