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Next-Generation Cartilage Solutions

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Sports Injuries

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Abstract

First-generation autologous chondrocyte implantation (ACI) introduced by Peterson has been proven capable of restoring hyaline cartilage tissue. Recent studies suggested the durability of this treatment, primarily due to its ability to produce hyaline-like cartilage that is mechanically and functionally stable. However, ACI requires two surgical procedures and showed local morbidity because of the periosteal harvest; to address these problems, the so-called second-generation ACI technique has been developed, utilizing a three-dimensional matrix seeded with chondrocytes, and the results at medium-term follow-up are well documented; however, it is still a high-cost procedure, and two surgical interventions are required.

Several improvements are soon expected, as the result of the rapidly growing knowledge on cell culture and chondrocyte biology and the positive effect of growth factors in order to have “one-step surgery” for cartilage repair and the use of autologous mesenchymal stem cells (MSCs) in a temporary scaffold could be an improvement on the currently available techniques.

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Authors and Affiliations

  1. Department of Orthopaedics, Osaka Health Science University, 2-2, Yamadaoka, Suita, 565-0871, Osaka, Japan

    Norimasa Nakamura

  2. Department of Rehabilitation Science, Osaka University Center for Advanced Medical Engineering and Informatics, 1-9-27 Tenma, Kita-ku, 530-0043, Osaka, Japan

    Norimasa Nakamura

  3. Orthopaedic Arthroscopic Surgery International (O.A.S.I.) Bioresearch Foundation, Gobbi N.P.O., Street via Amadeo 24, 20133, Milan, Italy

    Alberto Gobbi & Georgios Karnatzikos

Authors
  1. Norimasa Nakamura
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  2. Alberto Gobbi
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  3. Georgios Karnatzikos
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Correspondence to Norimasa Nakamura .

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Editors and Affiliations

  1. Dept. Orthopedics & Traumatology, Hacettepe University Fac. Medicine, Ankara, Turkey

    Mahmut Nedim Doral

  2. Gothenburg, Sweden

    Jon Karlsson

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Nakamura, N., Gobbi, A., Karnatzikos, G. (2014). Next-Generation Cartilage Solutions. In: Doral, M., Karlsson, J. (eds) Sports Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36801-1_155-1

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  • DOI: https://doi.org/10.1007/978-3-642-36801-1_155-1

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