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Role of Growth Factors in Anterior Cruciate Ligament Surgery

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Sports Injuries

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Abstract

Biological treatments to complement surgery have been shown to improve surgical outcomes. These improvements have been appreciated as a potential acceleration in tendon maturation. Numerous studies on anterior cruciate ligament grafts have shown accelerated maturation or ligamentization with the help of biological treatments such as plasma rich in growth factors.

Studies both in vitro and in animals, including human studies, have reported improved results in ligament structure and strength and earlier ACL graft maturation, with the use of growth factors.

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References

  • Aim A, Liljedahl SO, Stromberg B (1979) Clinical and experimental experience in the reconstruction of the anterior cruciate ligament. Orthop Clin North Am 7:181–189

    Google Scholar 

  • Anderson K, Seneviratne AM, Izawa K, Atkinson BL, Potter HG, Rodeo SA (2001) Augmentation of tendon healing in an intraarticular bone tunnel with use of a bone growth factor. Am J Sports Med 29:689–698

    Article  CAS  Google Scholar 

  • Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT (2004) Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 91(1):4–15

    Article  CAS  Google Scholar 

  • Anitua E, Sanchez M, Nurden AT, Zalduendo M, de la Fuente M, Orive G et al (2006) Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A 77(2):285–293

    Article  Google Scholar 

  • Anitua E, Sanchez M, Orivea G, Andía I (2007) The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials 28:4551–4560

    Article  CAS  Google Scholar 

  • Arnoczky SP, Tarvin GB (1982) Anterior cruciate ligament replacement using patellar tendon: an evaluation of graft revascularization in the dog. J Bone Joint Surg Am 64:217–224

    Article  CAS  Google Scholar 

  • Aspenberg P, Virchenko O (2004) Platelet concentrate injection improves Achilles tendon repair in rats. Acta Orthop Scand 75:93–99

    Article  Google Scholar 

  • Bennett NT, Schultz GS (1993a) Growth factors and wound healing: biochemical properties of growth factors and their receptors. Am J Surg 165(6):728–737

    Article  CAS  Google Scholar 

  • Bennett NT, Schultz GS (1993b) Growth factors and wound healing: part II Role in normal and chronic wound healing. Am J Surg 166(1):74–81

    Article  CAS  Google Scholar 

  • Cimino F, Volk BS, Setter D (2010) Anterior cruciate ligament injury: diagnosis, management and prevention. Am Fam Physician 82(8):917–922

    Google Scholar 

  • Cohen SB, Sekiya JK (2007) Allograft safety in anterior cruciate ligament reconstruction. Clin Sports Med 26:597–605

    Article  Google Scholar 

  • De Mos M, van der Windt A, Jahr H et al (2008) Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 36:1171–1178

    Article  Google Scholar 

  • Ekdahl M, Wang JH, Ronga M, Fu FH (2008) Graft healing in anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 16(10):935–947

    Article  Google Scholar 

  • Falconiero RP, DiStefano VJ, Cook TM (1998) Revascularization and ligamentization of autogenous anterior cruciate ligament grafts in humans. Arthroscopy 14:197–205

    Article  CAS  Google Scholar 

  • Fernandez-Sarmiento JA, Dominguez JM, Granados MM, Morgaz J, Navarrete J, Carrillo JM et al (2013) Histological study of the influence of plasma rich in growth factors (ORGF) on the healing of divided Achilles tendons in sheep. J Bone Joint Surg Am 95(3):246–255

    Article  Google Scholar 

  • Foster TE, Puskas BL, Mandelbaum BR et al (2009) Platelet-rich plasma. From basic science to clinical applications. Am J Sports Med 37:2259–2272

    Article  Google Scholar 

  • Gillquist J, Messner K (1999) Anterior cruciate ligament reconstruction and the long-term incidence of gonarthrosis. Sports Med 27(3):143–156

    Article  CAS  Google Scholar 

  • Goldstein J, Bosco JA 3rd (2001) The ACL-deficient knee: natural history and treatment options. Bull Hosp Jt Dis 60:173–178

    Google Scholar 

  • Griffin LY, Agel J, Albohm MJ et al (2000) Noncontact anterior cruciate ligament injuries: risk factors and prevention strategies. J Am Acad Orthop Surg 8(3):141–150

    Article  CAS  Google Scholar 

  • Grøntvedt T, Engebretsen L, Rossvoll I et al (1996) Comparison between magnetic resonance imaging findings and knee stability: measurements after anterior cruciate ligament repair with and without augmentation. A five- to seven year follow-up of 52 patients. Am J Sports Med 23:729–735

    Article  Google Scholar 

  • Howell SM, Clark JA, Blasier RD (1991) Serial magnetic resonance imaging of hamstring anterior cruciate ligament autografts during the first year of implantation. Am J Sports Med 19:42–47

    Article  CAS  Google Scholar 

  • Kajikawa Y, Morihara T, Sakamoto H et al (2008) Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 215:837–845

    Article  CAS  Google Scholar 

  • Kondo E, Yasuda K, Yamanaka M et al (2005) Effects of administration of exogenous growth factors on biomechanical properties of the elongation-type anterior cruciate ligament injury with partial laceration. Am J Sports Med 33:188–196

    Article  Google Scholar 

  • Kovacevic D, Rodeo SA (2008) Biological augmentation of rotator cuff tendon repair. Clin Orthop 466:622–633

    Article  Google Scholar 

  • Ledent E, Wasteson A, Berlin G (1995) Growth factor release during preparation and storage of platelet concentrates. Vox Sang 68(4):205–209

    Article  CAS  Google Scholar 

  • Lohmander LS, Englund PM, Dahl LL, Roos EM (2007) The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med 35(10):1756–1769

    Article  Google Scholar 

  • Lopez-Vidriero E, Goulding KA, Simon DA, Sanchez M, Johnson DH (2010) The use of platelet rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy 26(2):269–278

    Article  Google Scholar 

  • Magnussen RA, Carey JL, Spindler KP (2011) Does autograft choice determine intermediate-term outcome of ACL reconstruction? Knee Surg Sports Traumatol Arthrosc 19(3):462–472

    Article  Google Scholar 

  • Nin JR, Gasque GM, Azcárate AV et al (2009) Has platelet-rich plasma any role in anterior cruciate ligament allograft healing? Arthroscopy 25(11):1206–1213

    Article  Google Scholar 

  • Orrego M, Larrain C, Rosales J et al (2008) Effects of platelet concentrate and bone plug on the healing of hamstring tendons in bone tunnel. Arthroscopy 24:1373–1380

    Article  Google Scholar 

  • Radice F, Yánez R, Gutiérrez V et al (2010) Comparison of magnetic resonance imaging findings in anterior cruciate ligament grafts with and without autologous platelet-derived growth factors. Arthroscopy 26(1):50–57

    Article  Google Scholar 

  • Randelli PS, Arrigoni P, Cabitza P, Volpi P, Maffulli N (2008) Autologous platelet rich plasma for arthroscopic rotator cuff repair: a pilot study. Disabil Rehabil 30(20-22):1584–1589

    Google Scholar 

  • Reed GL, Fitzgerald ML, Polgár J (2000) Molecular mechanisms of platelet exocytosis: insights into the “secrete” life of thrombocytes. Blood 96(10):3334–3342

    CAS  Google Scholar 

  • Rougraff BT, Shelbourne KD (1999) Early histologic appearance of human patellar tendon autografts used for anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 7:9–14

    Article  CAS  Google Scholar 

  • Sanchez M, Anitua E, Azofra J et al (2007) Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 35:245–251

    Article  Google Scholar 

  • Sánchez M, Anitua E, Azofra J, Prado R, Muruzabal F, Andia I (2010) Ligamentization of tendon grafts treated with an endogenous preparation rich in growth factors: gross morphology and histology. Arthroscopy 26(4):470–480

    Article  Google Scholar 

  • Seijas R, Ares O, Catala J, Alvarez-Diaz P, Cusco X, Cugat R (2013) Magnetic resonance imaging evaluation of patellar tendon graft remodeling after anterior cruciate ligament reconstruction with or without platelet-rich plasma. J Orthop Surg (Hong Kong) 21(1):10–14

    Article  Google Scholar 

  • Schnabel LV, Mohammed HO, Miller BJ et al (2007) Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res 25(2):230–240

    Article  CAS  Google Scholar 

  • Smith BA, Livesay GA, Woo SL (1993) Biology and biomechanics of the anterior cruciate ligament. Clin Sports Med 12:637–670

    Article  CAS  Google Scholar 

  • Stergiou N, Ristanis S, Morati C, Georgoulis AD (2007) Tibial rotation in anterior cruciate ligament (ACL) deficient and ACL-reconstructed knees: a theoretical proposition for the development of osteoarthritis. Sports Med 37:601–613

    Article  Google Scholar 

  • Stone DK (1998) Receptors: structure and function. Am J Med 105(3):244–250

    Article  CAS  Google Scholar 

  • Tayapongsak P, O’Brien DA, Monteiro CB, Arceo-Diaz LY (1994) Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofac Surg 52(2):161–165

    Article  CAS  Google Scholar 

  • Taylor DW, Petrera M, Hendry M, Theodoropoulos JS (2011) A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries. Clin J Sport Med 21(4):344–352

    Article  Google Scholar 

  • Vega JA, García-Suárez O, Martínez AA (2000) Cartílago articular y factores de crecimiento (primera parte). Mapfre Medicina 11:212–225

    Google Scholar 

  • Von Porat A, Roos EM, Roos H (2004) High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: a study of radiographic and patient relevant outcomes. Ann Rheum Dis 63(3):269–273

    Article  Google Scholar 

  • Wang-Saegusa A, Cugat R, Ares O et al (2011) Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop Trauma Surg 131(3):311–317

    Article  Google Scholar 

  • Weibrich G, Kleis WK (2002) Curasan PRP kit vs PCCS PRP system: collection efficiency and platelets counts of two different methods for the preparation of platelet rich plasma. Clin Oral Implants 13:437–443

    Article  Google Scholar 

  • Weiler A, Förster C, Hunt P et al (2004) The influence of locally applied platelet-derived growth factor–BB on free tendon graft remodeling after anterior cruciate ligament reconstruction. Am J Sports Med 32:881–891

    Article  Google Scholar 

  • Xie X, Wu H, Zhao S, Xie G, Huangfu X, Zhao J (2013) The effect of platelet-rich plasma on patterns of gene expression in a dog model of anterior cruciate ligament reconstruction. J Surg Res 180(1):80–88

    Article  CAS  Google Scholar 

  • Yasuda K, Tomita F, Yamazaki S, Minami A, Tohyama H (2004) The effect of growth factors on biomechanical properties of the bone–patellar tendon–bone graft after anterior cruciate ligament reconstruction: a canine model study. Am J Sports Med 32:870–880

    Article  Google Scholar 

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Authors and Affiliations

  1. Chair of Medicine and Regenerative Surgery, Garcia Cugat Foundation & CEU Cardenal Herrera University, Alfara del Patriarca, C/Tirant lo Blanc, 7, Valencia, Spain

    Roberto Seijas & Pedro Álvarez

  2. Department of Orthopaedic Surgery, Sports Medicine and Trauma, Hospital Quiron Barcelona, Plaza Alfonso Comin, 5-7, Barcelona, Spain

    Roberto Seijas

  3. Facultad de Medicina y Ciencias de la Salud, Universitat Internacional de Catalunya, Immaculada, 22, Barcelona, Spain

    Roberto Seijas & Pedro Álvarez

  4. Mutualidad de Futbolistas, Real Federacion Espanola de Futbol, Ronda de San Pedro 19, Barcelona, Spain

    Pedro Álvarez & Ramón Cugat

  5. Department of Orthopaedic Surgery, Sports Medicine and Trauma, Hospital Quiron Barcelona, Artroscopia gc, S.L., Barcelona, Spain

    Pedro Álvarez & Ramón Cugat

  6. Facultad de Medicina, Universitat Internacional de Catalunya, Barcelona, Spain

    Pedro Álvarez & Ramón Cugat

  7. Garcia Cugat Foundation & CEU Cardenal Herrera University, Alfara del Patriarca, C/Tirant lo Blanc, 7, Valencia, Spain

    Ramón Cugat

Authors
  1. Roberto Seijas
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  2. Pedro Álvarez
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  3. Ramón Cugat
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Corresponding author

Correspondence to Roberto Seijas .

Editor information

Editors and Affiliations

  1. Department of Orthopaedics and Traumatology and Department of Sports Medicine, Hacettepe University, Istanbul, Turkey

    Mahmut Nedim Doral

  2. Department of Orthopaedic Surgery, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

    Jon Karlsson

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Seijas, R., Álvarez, P., Cugat, R. (2015). Role of Growth Factors in Anterior Cruciate Ligament Surgery. In: Doral, M.N., Karlsson, J. (eds) Sports Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36569-0_97

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  • DOI: https://doi.org/10.1007/978-3-642-36569-0_97

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  • Print ISBN: 978-3-642-36568-3

  • Online ISBN: 978-3-642-36569-0

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