Nomenclature
EC number
1.14.11.29
Systematic name
hypoxia-inducible factor-l-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
Recommended name
hypoxia-inducible factor-proline dioxygenase
Synonyms
HIF prolyl <5> [4]
HIF prolyl hydroxylase <1,2,4> [4]
HIF-P4H-1 <2> [1]
HIF-P4H-2 <4> [1]
HIF-P4H-3 <3> [1]
HIF-PH <2> [3]
HIF-α prolyl-hydroxylase <2> [3]
HPH-1 <2> [4]
HPH-2 <4> [4]
HPH-3 <5> [4]
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References
Hirsila, M.; Koivunen, P.; Gunzler, V.; Kivirikko, K.I.; Myllyharju, J.: Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem., 278, 30772-30780 (2003)
Ivan, M.; Kondo, K.; Yang, H.F.; Kim, W.; Valiando, J.; Ohh, M.; Salic, A.; Asara, J.M.; Lane, W.S.; Kaelin, W.G.: HIF α targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science, 292, 464-468 (2001)
Jaakkola, P.; Mole, D.R.; Tian, Y.M.; Wilson, M.I.; Gielbert, J.; Gaskell, S.J.; von Kriegsheim, A.; Hebestreit, H.F.; Mukherji, M.; Schofield, C.J.; Maxwell, P.H.; Pugh, C.W.; Ratcliffe, P.J.: Targeting of HIF- α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 292, 468-472 (2001)
Bruick, R.K.; McKnight, S.L.: A conserved family of prolyl-4-hydroxylases that modify HIF. Science, 294, 1337-1340 (2001)
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Schomburg, D., Schomburg, I. (2013). hypoxia-inducible factor-proline dioxygenase 1.14.11.29. In: Schomburg, D., Schomburg, I. (eds) Class 1 Oxidoreductases. Springer Handbook of Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36265-1_71
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