Nomenclature
EC number
6.3.1.13
Systematic name
l-cysteine:1-O-(2-amino-2-deoxy-α-d-glucopyranosyl)-1d-myo-inositol ligase (AMP-forming)
Recommended name
l-cysteine:1d-myo-inositol 2-amino-2-deoxy-α-d-glucopyranoside ligase
Synonyms
Cys:GlcN-Ins ligase <1,2> [1]
l-cysteine:1-d-myo-inosityl 2-amino-2-deoxy-α-d-glucopyranoside ligase <2> [2]
MshC <1,2,3> [2,3,4,5,6,7]
MshC ligase <1,2> [1]
cysteine ligase <1> [3]
mycothiol ligase <1> [4]
Additional information <1,2> (<1,2> enzyme is related to class I cysteinyltRNA synthetase [1]) [1]
CAS registry number
442171-76-8
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References
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Newton, G.L.; Ta, P.; Sareen, D.; Fahey, R.C.: A coupled spectrophotometric assay for l-cysteine:1-d-myo-inosityl 2-amino-2-deoxy-α-d-glucopyranoside ligase and its application for inhibitor screening. Anal. Biochem., 353, 167-173 (2006)
Fan, F.; Luxenburger, A.; Painter, G.F.; Blanchard, J.S.: Steady-state and pre-steady-state kinetic analysis of Mycobacterium smegmatis cysteine ligase (MshC). Biochemistry, 46, 11421-11429 (2007)
Gutierrez-Lugo, M.T.; Newton, G.L.; Fahey, R.C.; Bewley, C.A.: Cloning, expression and rapid purification of active recombinant mycothiol ligase as B1 immunoglobulin binding domain of streptococcal protein G, glutathione-S- transferase and maltose binding protein fusion proteins in Mycobacterium smegmatis. Protein Expr. Purif., 50, 128-136 (2006)
Tremblay, L.W.; Fan, F.; Vetting, M.W.; Blanchard, J.S.: The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway. Biochemistry, 47, 13326-13335 (2008)
Williams, L.; Fan, F.; Blanchard, J.S.; Raushel, F.M.: Positional isotope exchange analysis of the Mycobacterium smegmatis cysteine ligase (MshC). Biochemistry, 47, 4843-4850 (2008)
Dosanjh, M.; Newton, G.L.; Davies, J.: Characterization of a mycothiol ligase mutant of Rhodococcus jostii RHA1. Res. Microbiol., 159, 643-650 (2008)
Gutierrez-Lugo, M.T.; Baker, H.; Shiloach, J.; Boshoff, H.; Bewley, C.A.: Dequalinium, a new inhibitor of Mycobacterium tuberculosis mycothiol ligase identified by high-throughput screening. J. Biomol. Screen., 14, 643-652 (2009)
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Schomburg, D., Schomburg, I. (2013). L-cysteine:1d-myo-inositol 2-amino-2-deoxy-α-d-glucopyranoside ligase 6.3.1.13. In: Schomburg, D., Schomburg, I. (eds) Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases. Springer Handbook of Enzymes, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36260-6_87
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