Nomenclature
EC number
4.2.99.20 (formerly a partial reaction of EC 2.5.1.64)
Systematic name
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate pyruvatelyase [(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate-forming]
Recommended name
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Synonyms
(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase <1> [2,3]
MenH <1> [2,3]
SHCHC <1> [3]
SHCHC synthase <1,2> [1,2]
YfbB <1> [2]
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References
Jiang, M.; Cao, Y.; Guo, Z.F.; Chen, M.; Chen, X.; Guo, Z.: Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity. Biochemistry, 46, 10979-10989 (2007)
Jiang, M.; Chen, X.; Guo, Z.F.; Cao, Y.; Chen, M.; Guo, Z.: Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli. Biochemistry, 47, 3426-3434 (2008)
Jiang, M.; Chen, X.; Wu, X.H.; Chen, M.; Wu, Y.D.; Guo, Z.: Catalytic mechanism of SHCHC synthase in the menaquinone biosynthesis of Escherichia coli: identification and mutational analysis of the active site residues. Biochemistry, 48, 6921-6931 (2009)
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Schomburg, D., Schomburg, I. (2013). 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase 4.2.99.20. In: Schomburg, D., Schomburg, I. (eds) Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases. Springer Handbook of Enzymes, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36260-6_71
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DOI: https://doi.org/10.1007/978-3-642-36260-6_71
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