Nomenclature
EC number
4.2.1.114
Systematic name
(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming]
Recommended name
methanogen homoaconitase
Synonyms
HACN <1,2> [1,2]
Homoaconitase <2> [1]
MJ1003 <1> (<1> large subunit protein of HACN [2]) [2]
MJ1271 <1> (<1> small subunit protein of HACN [2]) [2]
methanogen HACN
Additional information <2> (<2> the enzyme belongs to the aconitase superfamily [1]) [1]
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References
Drevland, R.M.; Jia, Y.; Palmer, D.R.; Graham, D.E.: Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis. J. Biol. Chem., 283, 28888-28896 (2008)
Jeyakanthan, J.; Drevland, R.M.; Gayathri, D.R.; Velmurugan, D.; Shinkai, A.; Kuramitsu, S.; Yokoyama, S.; Graham, D.E.: Substrate specificity determinants of the methanogen homoaconitase enzyme: structure and function of the small subunit. Biochemistry, 49, 2687-2696 (2010)
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Schomburg, D., Schomburg, I. (2013). methanogen homoaconitase 4.2.1.114. In: Schomburg, D., Schomburg, I. (eds) Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases. Springer Handbook of Enzymes, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36260-6_41
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