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MDS Stem Cell Biology

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Myelodysplastic Syndromes

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

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Abstract

The clinical heterogeneity of patients with myelodysplastic syndromes suggests that there must also be a broad range of pathogenetic abnormalities that underlie this disorder. It is clear that the molecular abnormalities associated with MDS are vast, as are the functional abnormalities within the hematopoietic compartment. This implies that there may also be significant differences in the cell of origin and varying degrees of aberrant communication with the microenvironment in individual patients. It is only through recent advances in flow cytometry, DNA sequencing, and high throughput analysis of the genome, proteome, and RNA expression profiles that we can make these general but profound statements about the spectrum of abnormalities in MDS patients.

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Authors and Affiliations

  1. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1550 NW 10th Avenue, BRB 742C, Miami, FL, 33136, USA

    Sarah M. Greenblatt

  2. Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D1-100, Seattle, WA, 98109-1024, USA

    H. Joachim Deeg MD

  3. University of Washington School of Medicine, Seattle, WA, USA

    H. Joachim Deeg MD

  4. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1550 NW 10th Avenue, FOX 200, Miami, FL, 33136, USA

    Stephen D. Nimer MD

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  1. Sarah M. Greenblatt
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  2. H. Joachim Deeg MD
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  3. Stephen D. Nimer MD
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Correspondence to Stephen D. Nimer MD .

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Greenblatt, S.M., Deeg, H.J., Nimer, S.D. (2013). MDS Stem Cell Biology. In: Myelodysplastic Syndromes. Hematologic Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36229-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-36229-3_4

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