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Molecular Evolution of the Microfibril-Associated Proteins: The Fibulins and the MAGPs

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Evolution of Extracellular Matrix

Part of the book series: Biology of Extracellular Matrix ((BEM))

Abstract

This chapter reviews the evolutionary histories of two representative families of microfibril-associated proteins as distinctive examples of adding evolutionary novelty to the ancient microfibril genetic module. The microfibril-associated glycoproteins (MAGPs), a recent addition to the microfibril, evolved from a MAGP1-like gene in basal vertebrates. The extant MAGP1 and MAGP2 genes arose in a multigene duplication event, with functional divergence mediated by relaxation of natural selection and correlated evolution between MAGP2 and Notch1. Unique MAGP1 functions in bony vertebrates likely evolved by gain of function at the N-terminus. The fibulins (FBLNs) appeared at the base of the metazoans, contemporaneously with the Fibrillin gene. Diversification accelerated in chordates and vertebrates, to a total of nine FBLN genes. The vertebrate FBLN3/4/5 clade of elastogenic FBLNs evolved from a chordate ancestor by two gene duplication events in quick succession. Accelerated evolution in sequence and expression patterns occurred preferentially on the FBLN5 branch. Coevolution of functional motifs in FBLN3/4/5 with their partners in elastic fiber deposition contributed to the nonredundant specialization of the elastogenic FBLNs.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA, 19104, USA

    Fernando Segade

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  1. Fernando Segade
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Correspondence to Fernando Segade .

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  1. Hospital for Sick Children, Toronto, Ontario, Canada

    Fred W. Keeley

  2. Dept. Cell Biology & Physiology, Washington University School of Medicine, St. Louis, Missouri, USA

    Robert P. Mecham

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Segade, F. (2013). Molecular Evolution of the Microfibril-Associated Proteins: The Fibulins and the MAGPs. In: Keeley, F., Mecham, R. (eds) Evolution of Extracellular Matrix. Biology of Extracellular Matrix. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36002-2_6

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