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Toxicokinetic Models

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Regulatory Toxicology

Abstract

Toxicokinetics describes by means of mathematical functions the time- and dose-dependent processes of absorption, distribution, metabolism, and excretion of a substance in animals and humans. For this purpose, toxicokinetic models are used, mostly straightforward compartment models by which toxicokinetic in vivo data are fitted or physiological toxicokinetic models that enable to predict species-specifically the substance burdens in various tissues and organs. Toxicokinetic information is required for the quantitative assessment of the substance-specific health risk carried out by national and international agencies responsible for regulating health and safety.

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Recommended Reading

  • Bisswanger H (2008) Enzyme kinetics, 2nd edn. Wiley-VCH, Weinheim

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  • Filser JG, Bogdanffy MS [guest editors] (2003) Application of physiological-toxicokinetic modelling to health hazard assessment of chemical substances. Toxicol Lett 138(1/2):1–184

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  • Gibaldi M, Perrier D (1982) Pharmacokinetics, 2nd edn. Marcel Dekker, New York

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  • Reddy M, Yang RS, Andersen ME, Clewell HJ III (2005) Physiologically based pharmacokinetic modeling: science and applications. Wiley, Hoboken

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  • Ritschel WA, Kearns GL (2004) Handbook of basic pharmacokinetics – including clinical applications, 6th edn. American Pharmacists Association, Washington DC

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Author information

Authors and Affiliations

  1. Institute for Toxicology and Environmental Hygiene, Technical University of Munich, Munich, Germany

    Johannes Georg Filser

Authors
  1. Johannes Georg Filser
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Corresponding author

Correspondence to Johannes Georg Filser .

Editor information

Editors and Affiliations

  1. Walther-Straub-Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany

    Franz-Xaver Reichl

  2. Formerly Medical School, Hannover, Germany

    Michael Schwenk

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© 2014 Springer-Verlag Berlin Heidelberg

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Filser, J.G. (2014). Toxicokinetic Models. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35374-1_49

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