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Proteinanalyse und Molekularforschung

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Lungenmetastasen

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Zusammenfassung

Die Tumorprogression zu Fernmetastasen beinhaltet eine Reihe von Ereignissen, die man unter dem Begriff der „metastatischen Kaskade“ zusammenfasst. Nachdem eine maligne Transformation einer Zelle zur Bildung eines primären Tumors geführt hat, erfolgt in der Tumormasse eine Neovaskularisierung (Angiogenese). Einzelne Zellen oder ganze Zellgruppen wandern anschließend in die umgebende extrazelluläre Matrix (ECM) und das gesunde Stroma (Migration, Invasion) ein. Die molekulare Grundlage für die Dissoziation von Tumorzellen aus dem Primärverband ist die Reaktivierung von embryonalen Signalwegen. Ein dafür verantwortlicher Schlüsselmechanismus ist die epitheliale-mesenchymale Transition (EMT). Sie bewirkt die Auflösung der Zell-Zell-Kontakte, Aufhebung der Zellpolarität und Reorganisation des Zytoskeletts durch eine Umwandlung der Zelle von einem epithelialen in einen mesenchymalen Phänotyp.

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Authors and Affiliations

  1. Sektion für Translationale Onkologie & Biobanking, Klinik für Allgemeine Chirurgie, Universitätsklinikum Schleswig Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland

    T. Gemoll M.Sc., Sarah Strohkamp M. sc. & J. K. Habermann

  2. Klinik für Allgemeine, Viszerale, Thorax, Missionsärztliche Klinik, Salvatorstr. 7, 97074, Würzburg, Deutschland

    Priv.-Doz. Stefan Limmer

Authors
  1. T. Gemoll M.Sc.
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  2. Sarah Strohkamp M. sc.
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  3. Priv.-Doz. Stefan Limmer
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  4. J. K. Habermann
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Correspondence to T. Gemoll M.Sc. .

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Editors and Affiliations

  1. Klinik für Allgemeine, Viszerale, Thorax, Missionsärztliche Klinik, Würzburg, Germany

    Stefan Limmer

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Gemoll, T., Strohkamp, S., Limmer, S., Habermann, J. (2015). Proteinanalyse und Molekularforschung. In: Limmer, S. (eds) Lungenmetastasen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32982-1_3

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  • DOI: https://doi.org/10.1007/978-3-642-32982-1_3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-32981-4

  • Online ISBN: 978-3-642-32982-1

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