Skip to main content
SpringerLink
Log in

Optical Coherence Tomography

  • Chapter
  • First Online:
Non Invasive Diagnostic Techniques in Clinical Dermatology

  • 2587 Accesses

Abstract

Optical coherence tomography (OCT) is a noninvasive imaging method. Using infrared broadband light sources, images of superficial skin layers can be obtained in vivo and real time. In dermatology, OCT can be used for investigation of skin tumors and inflammatory skin diseases, for quantification of skin changes, and for evaluation of treatment effects (Gambichler et al., J Dermatol Sci 40:85–94, 2005; Gambichler et al., Arch Derm Res 303:457–473, 2011; Huang et al., Science 254:1178–1181, 1991; Pagnoni et al., Skin Res Technol 5:83–87, 1999; Pierce et al., J Invest Dermatol 123:458–463, 2004; Schmitt, Dermatology 217:12–13, 2008; Welzel et al., J Am Acad Dermatol 37:958–963, 1997; Welzel, Skin Res Technol 7:1–9, 2001).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Alex A, Považay B, Hofer B et al (2010) Multispectral in vivo three-dimensional optical coherence tomography of human skin. J Biomed Opt 15:026025–026015

    Article  PubMed  Google Scholar 

  2. Bechara FG, Gambichler T, Stücker M et al (2004) Histomorphologic correlation with routine histology and optical coherence tomography. Skin Res Technol 10:169–173

    Article  PubMed  CAS  Google Scholar 

  3. Cobb MJ, Chen Y, Underwood RA, Usui ML, Olerud J, Li X (2010) Non-invasive assessment of cutaneous wound healing using ultrahigh-resolution optical coherence tomography. J Biomed Opt 11:064002

    Article  Google Scholar 

  4. Coßmann M, Welzel J (2006) Evaluation of the atrophogenic potential of different glucocorticoids using optical coherence tomography, 20-MHz ultrasound and profilometry; a double-blind, placebo-controlled trial. Br J Dermatol 155:700–706

    Article  PubMed  Google Scholar 

  5. De Boer JF, Cense B, Park BH, Pierce MC, Tearney GJ, Bouma BE (2003) Improved signal-to-noise ratio in spectral-domain compared to time-domain optical coherence tomography. Opt Lett 28:2067–2069

    Article  PubMed  Google Scholar 

  6. Drexler W (2004) Ultrahigh-resolution optical coherence tomography. J Biomed Opt 9:47–74

    Article  PubMed  Google Scholar 

  7. Gambichler T, Boms S, Stücker M, Moussa G, Kreuter A, Sand M, Sand D, Altmeyer P, Hoffmann K (2005) Acute skin alterations following ultraviolet radiation investigated by optical coherence tomography and histology. Arch Dermatol Res 297:218–225

    Article  PubMed  Google Scholar 

  8. Gambichler T, Moussa G, Sand M, Sand D, Altmeyer P, Hoffmann K (2005) Applications of optical coherence tomography in dermatology. J Dermatol Sci 40:85–94

    Article  PubMed  Google Scholar 

  9. Gambichler T, Matip R, Moussa G, Altmeyer P, Hoffmann K (2006) In vivo data of epidermal thickness evaluated by optical coherence tomography: effects of age, gender, skin type, and anatomic site. J Dermatol Sci 44:145–152

    Article  PubMed  Google Scholar 

  10. Gambichler T, Regeniter P, Bechara FG, Orlikov A, Vasa R, Moussa G, Stücker M, Altmeyer P, Hoffmann K (2007) Characterization of benign and malignant melanocytic skin lesions using optical coherence tomography in vivo. J Am Acad Dermatol 57:629–637

    Article  PubMed  Google Scholar 

  11. Gambichler T, Orlikov A, Vasa R et al (2007) In vivo optical coherence tomography of basal cell carcinoma. J Dermatol Sci 45:167–173

    Article  PubMed  Google Scholar 

  12. Gambichler T, Jaedicke V, Terras S (2011) Optical coherence tomography in dermatology: technical and clinical aspects. Arch Dermatol Res 303:457–473

    Article  PubMed  Google Scholar 

  13. Huang D, Swanson EA, Lin CP, Shuman JS, Stinson WG, Chang W et al (1991) Optical coherence tomography. Science 254:1178–1181

    Article  PubMed  CAS  Google Scholar 

  14. Korde VR, Garret TB, Wei X et al (2007) Using optical coherence tomography to evaluate skin sun damage and precancer. Lasers Surg Med 39:687–695

    Article  PubMed  Google Scholar 

  15. König K, Speicher M, Bückle R, Reckfort J, McKenzie G, Welzel J, Köhler MJ, Elsner P, Kaatz M (2009) Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases. J Biophotonics 2:389–397

    Article  PubMed  Google Scholar 

  16. Leitgeb R, Hitzenberger C, Fercher A (2003) Performance of fourier domain vs. time domain optical coherence tomography. Opt Express 11:889–894

    Article  PubMed  CAS  Google Scholar 

  17. Mogensen M, Morsy HA, Nurnberg BM, Jemec GB (2008) Optical coherence tomography imaging of bullous diseases. J Eur Acad Dermatol Venereol 22:1458–1464

    Article  PubMed  CAS  Google Scholar 

  18. Mogensen M, Morsy HA, Thrane L, Jemec GB (2008) Morphology and epidermal thickness of normal skin imaged by optical coherence tomography. Dermatology 217:14–20

    Article  PubMed  Google Scholar 

  19. Mogensen M, Joergensen TM, Nürnberg BM, Morsy HA, Thomsen JB, Thrane L, Jemec GB (2009) Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg 35:965–972

    Article  PubMed  CAS  Google Scholar 

  20. Mogensen M, Nürnberg BM, Forman JL, Thomsen JB, Thrane L, Jemec GBE (2009) In vivo thickness measurement of basal cell carcinoma and actinic keratosis with optical coherence tomography and 20-MHz ultrasound. Br J Dermatol 160:1026–1033

    Article  PubMed  CAS  Google Scholar 

  21. Morsy H, Kamp S, Thrane L, Behrendt N, Zayan H, Elmagid EA, Jemec GBE (2010) Optical coherence tomography imaging of psoriasis vulgaris: correlation with histology and disease severity. Arch Dermatol Res 302(2):105–111. doi:10.1007/s00403-009-1000-4

    Article  PubMed  Google Scholar 

  22. Neerken S, Lucassen GW, Bisschop MA et al (2004) Characterization of age-related effects in human skin: a comparative study that applies confocal laser scanning microscopy and optical coherence tomography. J Biomed Opt 9:274–281

    Article  PubMed  Google Scholar 

  23. Olmedo JM, Karen EW, Joseph MS, David LS (2007) Correlation of thickness 758 of basal cell carcinoma by optical coherence tomography in vivo and routine histologic findings: a pilot study. Dermatol Surg 33:421–426

    Article  PubMed  CAS  Google Scholar 

  24. Pagnoni A, Knuettel A, Welker P et al (1999) Optical coherence tomography in dermatology. Skin Res Technol 5:83–87

    Article  Google Scholar 

  25. Patil CA, Bosschaart N, Keller MD, Van Leeuwen TG, Mahadevan-Jansen A (2008) Combined Raman spectroscopy and optical coherence tomography device for tissue characterization. Opt Lett 33:1135–1137

    Article  PubMed  Google Scholar 

  26. Pierce MC, Strasswimmer J, Hyle Park B, Cense B, de Boer JF (2004) Advances in optical coherence tomography imaging for dermatology. J Invest Dermatol 123:458–463

    Article  PubMed  CAS  Google Scholar 

  27. Rothmund G, Sattler E, Kästle R, Fischer C, Haas CJ, Starz H, Welzel J (2013) Confocal laser scanning microscopy as a new valuable tool in the diagnosis of onychomycosis – comparison of six diagnostic methods. Mycoses 56(1):47–55

    Article  PubMed  CAS  Google Scholar 

  28. Sattler E, Kaestle R, Rothmund G, Welzel J (2012) Confocal laser scanning microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails. Br J Dermatol 166(4):740–746. doi:10.1111/j.1365-2133.2011.10730.x

    Article  PubMed  CAS  Google Scholar 

  29. Schmitt AM (2008) Principles and application of optical coherent tomography in dermatology. Dermatology 217:12–13

    Article  PubMed  Google Scholar 

  30. Welzel J, Lankenau E, Birngruber R, Engelhardt R (1997) Optical coherence tomography of the human skin. J Am Acad Dermatol 37:958–963

    Article  PubMed  CAS  Google Scholar 

  31. Welzel J (2001) Optical coherence tomography in dermatology : a review. Skin Res Technol 7:1–9

    Article  PubMed  CAS  Google Scholar 

  32. Welzel J, Bruhns M, Wolff HH (2003) Optical coherence tomography in contact dermatitis and psoriasis. Arch Dermatol Res 295:50–55

    Article  PubMed  Google Scholar 

  33. Welzel J, Reinhardt C, Lakenau E et al (2004) Changes in function and morphology of normal human skin: evaluation using optical coherence tomography. Br J Dermatol 150:220–225

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, General Hospital Augsburg, Sauerbruchstrasse 6, D-86179, Augsburg, Germany

    Julia Welzel

Authors
  1. Julia Welzel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Clinical Dermatology, San Gallicano Dermatological Institute, Rome, Roma, Italy

    Enzo Berardesca

  2. Dermatology, University of California San Francisco, San Francisco, CA, California, USA

    Howard I. Maibach

  3. Proderm, Schenefeld/Hamburg, Germany

    Klaus-Peter Wilhelm

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Welzel, J. (2014). Optical Coherence Tomography. In: Berardesca, E., Maibach, H., Wilhelm, KP. (eds) Non Invasive Diagnostic Techniques in Clinical Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32109-2_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-32109-2_3

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-32108-5

  • Online ISBN: 978-3-642-32109-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation