Abstract
Sonography is the oldest noninvasive cross-sectional method to study the skin. Due to technical improvements and advances in signal and image processing in the past 30 years, high-resolution sonography has become a routine diagnostic tool in dermatology.
To study the uppermost skin layers, the axial and lateral resolution was increased significantly. In normal palmar skin, the horny layer is represented as echopoor band below the skin entry echo, traversed by echorich coils, which correspond to eccrine sweat gland ducts. The thickness of this band markedly increases after occlusive application of petrolatum. Its lower border is defined by a thin, echorich line, representing the stratum corneum/stratum Malpighii interface. Underneath, a second echopoor band is visible, which corresponds to the viable epidermis plus the papillary dermis, bordered by the scattered echo reflexes of the reticular dermis. Sonograms of normal glabrous skin show only one echopoor band between the entry echo and the dermal reflexes, corresponding to the viable epidermis plus the papillary dermis. The horny layer cannot be distinguished as a separate structure. Using image analysis and statistical methods on sonograms of skin tumors (malignant melanoma, naecocellurlar nevus, scborhocic keratosis, basal cell carcinoma) and inflammatory diseases (psoriasis, lichen planus) we were able to evaluate the usefullness and the limits of high resolution sonography. Our results show that sonography is a valuable tool for in vivo examination of different normal and pathological skin conditions, ranging from the upper epidermis the to .muscle fascia.
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References
Ablett S, Burdett NG, Carpenter TA, Hall LD, Salter DC (1996) Short echo time MRI enables visualisation of the natural state of human stratum corneum water in vivo. Magn Reson Imaging 13:357–360
Akesson A, Forsberg L, Hederström E, Wollheim E (1986) Ultrasound examination of skin thickness in patients with progressive systemic sclerosis (scleroderma). Acta Radiol Diagn 27:91–94
Alexander H, Miller DL (1979) Determining skin thickness with pulsed ultrasound. J Invest Dermatol 72:17–19
Altmeyer P, Hoffmann K, Stücker M, Goertz S, El-Gammal S (1992) General phenomena of ultrasound in dermatology. In: Altmeyer P, El-Gammal S, Hoffmann K (eds) Ultrasound in dermatology. Springer, Berlin/Heidelberg/New York, pp 55–79
Beck JS, Speace VA, Lowe JG, Gibbs JH (1986) Measurement of skin swelling in the tuberculin test by ultrasonography. J Immunol Methods 86:125–130
Beyer D, Peters PE, Friedmann G (1982) Leistungsbreite der Real-time-Sonographie bei Lymphknotenerkrankungen. Rontgenpraxis 35:393–402
Blum A, Dill-Müller D (1998) Sonographie der Lymphknoten und der Subkutis in der Dermatologie; Teil 1. Hautarzt 49:942–949
Blum A, Dill-Müller D (1999) Sonographie der Lymphknoten und der Subkutis in der Dermatologie; Teil 2. Hautarzt 50:62–73
Blum A, Schlagenhauff B, Stroebel W, Breuninger H, Rassner G, Garbe C (2000) Ultrasound examination of regional lymph nodes significantly improves early detection of locoregional metastases during the follow-up of patients with cutaneous melanoma. Cancer 88:2534–2539
Brockmann WP, Maas R, Voigt H, Thoma G, Schweer S (1985) Veränderungen peripherer Lymphknoten im Ultraschall. Ultraschall 6:164–169
Cole CW, Handler SJ, Burnett K (1981) The ultrasonic evaluation of skin thickness in sklerederma. J Clin Ultrasound (NY) 9:501–503
Dill-Müller D, Maschke J (2007) Ultraschalldiagnositk in der Dermatologie. JDDG 5:689–708
Di Nardo A, Seidenari S, Giannetti A (1992) B-scanning evaluation with image analysis of psoriatic skin. Exp Dermatol 1:121–125
El Gammal S, Auer T, Hoffmann K, Altmeyer P, Paßmann C, Ermert H (1993) Grundlagen, Anwendungsgebiete und Grenzen des hochfrequenten (20–50 MHz) Ultraschalls in der Dermatologie. Zbl Haut 162:817–838
El Gammal S, Auer T, Hoffmann K, Matthes U, Altmeyer P (1992) Möglichkeiten und Grenzen der hochauflösenden (20 und 50 MHz) Sonographie in der Dermatologie. Akt Dermatol 18:197–208
El Gammal S, Auer T, Hoffmann K, Matthes U, Hammentgen R, Altmeyer P, Ermert H (1993) High-frequency ultrasound: a non-invasive method for use in dermatology. In: Frosch P, Kligman AM (eds) Non-invasive methods in dermatology. Springer, Heidelberg/New York, pp 104–129
El Gammal S, Auer T, Hoffmann K, Paßmann C, Ermert H (1995) High resolution ultrasound of the human epidermis. In: Serup J, Jemec GBE (eds) In vivo examination of the skin: a handbook of non-invasive methods. CRC Press, Ann Arbor/London/Tokyo, p 125
El Gammal S, El Gammal C, Altmeyer P, Vogt M, Ermert H (2007) Sonography of the skin in health and disease. In: Wilhelm KP, Elsner P, Berardesca E, Maibach HI (eds) Bioengineering of the skin – skin imaging and analysis. Informa Healthcare, New York, pp 353–375
El Gammal S, El Gammal C, Kaspar K, Pieck C, Altmeyer P, Vogt M, Ermert H (1999) Sonography of the skin at 100 MHz enables in-vivo-visualization of stratum corneum and viable epidermis in palmar skin and psoriatic plaques. J Invest Dermatol 113:821–829
El Gammal S, Hoffmann K, Auer T, Korten M, Altmeyer P, Höss A, Ermert H (1992b) A 50 MHz high-resolution imaging system for dermatology. In: Altmeyer P, el-Gammal S, Hoffmann K (eds) Ultrasound in dermatology. Springer, Heidelberg/New York, pp 297–322
El Gammal S, Hoffmann K, Kenkmann J, Altmeyer P, Höss A, Ermert H (1992c) Principles of three-dimensional reconstructions from high resolution ultrasound in dermatology. In: Altmeyer P, el-Gammal S, Hoffmann K (eds) Ultrasound in dermatology. Springer, Heidelberg/New York, pp 355–387
Fields S, Dunn F (1993) Correlation of echographic visualizability of tissue with biological composition and physiological state. J Acoust Soc Am 54:809–812
Finlay AY, Moseley H, Duggan TC (1987) Ultrasound transmission time: an in vivo guide to nail thickness. Br J Dermatol 117:765–770
Fornage BD, McGavran MH, Duvic M, Waldron CA (1993) Imaging of the skin with 20-MHz US. Radiology 189:69–76
Gniadecka M, Gniadecki R, Serup J, Søndergaard J (1994) Ultrasound structure and digital image analysis of the subepidermal low echogenic band in aged human skin: diurnal changes and interindividual variability. J Invest Dermatol 102:362–365
Gropper CA, Stiller MJ, Shupack JL, Driller J, Rorke M, Lizzi F (1993) Diagnostic high-resolution ultrasound in dermatology. Int J Dermatol 32:243–250
Gupta AK, Turnbull DH, Foster FS, Harasiewicz KA, Shum DT, Prussick R, Watteel GN, Horst LN, Sauder DN (1996) High-frequency 40-MHz ultrasound. A possible noninvasive method for the assessment of boundary of basal cell carcinoma. Dermatol Surg 22:131–136
Gupta AK, Turnbull DH, Harasiewicz KA, Shum DT, Watteel GN, Fister FS, Sauder DN (1996) The use of high-frequency ultrasound as a method of assessing the severity of a plaque of psoriasis. Arch Dermatol 132:658–662
Haller J, Gritzmann N, Czembirek H, Schmidbauer CH, Leitner H, Sommer G, Tscholakoff D (1987) Der okkulte und der klinisch verdächtige Hodentumor. Abklärung mittels Realtime-Sonographie. Radiologie 27:113–117
Harland CC, Bamber JC, Gusterson BA, Mortimer PS (1993) High frequency, high resolution B-scan ultrasound in the assessment of skin tumours. Br J Dermatol 128:525–532
Hoffmann K, Dirschka T, Schwarze H, el-Gammal S, Matthes U, Hoffmann A, Altmeyer P (1995) 20 MHz sonography, colorimetry and image analysis in the evaluation of psoriasis vulgaris. J Dermatol Sci 9:103–110
Hoffmann K, el-Gammal S, Gerbaulet U, Schatz H, Altmeyer P (1992a) Examination of circumscribed scleroderma using 20 MHz B-scan ultrasound. In: Altmeyer P, el-Gammal S, Hoffmann K (eds) Ultrasound in dermatology. Springer, Heidelberg/New York, pp 231–243
Hoffmann K, el-Gammal S, Winkler K, Jung J, Pistorius K, Altmeyer P (1992b) Skin tumours in high-frequency ultrasound. In: Altmeyer P, el-Gammal S, Hoffmann K (eds) Ultrasound in dermatology. Springer, Heidelberg/New York, pp 181–201
Hoffmann K, Stücker M, Dirschka T, Görtz S, el-Gammal S, Dirting K, Hoffmann A, Altmeyer P (1994) Twenty MHz B-scan sonography for visualization and skin thickness measurement of human skin. J Eur Acad Dermatol 3:302–313
Idson B (1978) Hydration and percutaneous absorption. Curr Probl Dermatol 7:132–134
Ihn H, Shimozuma M, Fujimoto M, Sato S, Kikuchi K, Igarashi A, Soma Y, Tamaki K, Takehara K (1995) Ultrasound measurement of skin thickness in systemic sclerosis. Br J Rheumatol 24:535–538
Jemec GB, Serup J (1989) Ultrasound structure of the human nail plate. Arch Dermatol 125:643–646
Kalia YN, Pirot F, Guy RH (1996) Homogeneous transport in a heterogeneous membrane: water diffusion across human stratum corneum in vivo. Biophys J 71:2692–2700
Kligman AM (1964) The biology of the stratum corneum. In: Montagna W, Lobitz WC (eds) The epidermis. Academic, New York, p 387
Leopold GR, Woo VL, Scheible W, Nachtsheim D, Gosink B (1979) High-resolution ultrasonography of scrotal pathology. Radiology 131:719–722
Lévy J, Gassmüller J, Audring H, Brenke A, Albrecht-Nebe H (1993) Darstellung der subkutanen Atrophie bei der zirkumskripten Sklerodermie im 20 MHz-B-scan Ultraschall. Hautarzt 44:446–451
Loose R, Weiss J, Kühn W, Simon R, Teubner J, Georgi M (1992) Comparison of ultrasound with clinical findings in the early detection of regional metastatic lymph nodes in patients with malignant melanoma. In: Altmeyer P, El Gammal S, Hoffmann K (eds) Ultrasound in dermatology. Springer, Heidelberg/New York, pp 93–99
Murakami S, Miki Y (1989) Human skin histology using high-resolution echography. J Clin Ultrasound 17:77–82
Myers SL, Cohen JS, Sheets PW, Bies JR (1986) B-mode ultrasound evaluation of skin thickness in progressive systemic sclerosis. J Rheumatol 13:577–580
Paßmann C, Ermert H, Auer T, Kaspar K, el-Gammal S, Altmeyer P (1989) In vivo ultrasound biomicroscopy. Proc IEEE Ultrasonics Symposium 1015–8
Paßmann C, Ermert H, Auer T, Kaspar K, el-Gammal S, Altmeyer P (1993) In vivo ultrasound biomicroscopy. Proc IEEE Ultrasonics Symposium 1015–8
Querleux B, Lévêque JL, de Rigal J (1988) In vivo cross-sectional ultrasonic imaging of the skin. Dermatologica 177:332–337
Querleux B, Richard S, Bittoun J, Jolivet O, Idy-Peretti I, Bazin R, Lévêque JL (1994) In vivo hydration profile in skin layers by high-resolution magnetic resonance imaging. Skin Pharmacol 7:210–216
Rukinava B, Mohar N (1979) An approach of ultrasound diagnostic techniques of the skin and subcutaneous tissue. Dermatologica 158:81–92
Schwartz SR, Murray RA (1991) Assessment of epithelial thickness by ultrasonic imaging. Decubitus 4:29–30
Schwerk WB, Schwerk WN (1989) Sonographie des Skrotalinhaltes (III-1.9.4.). In: Braun B, Günther R, Schwerk B (eds) Ultraschalldiagnostik. Lehrbuch und Atlas. Ecomed, München, pp 1–70
Seidenari S, Di Nardo A (1992) B scanning evaluation of irritant reactions with binary transformation and image analysis. Acta Derm Venereol Suppl (Stockh) 175:9–13
Seidenari S (1995) High-frequency sonography combined with image analysis: a non-invasive objective method for skin evaluation and description. Clin Dermatol 13:349–359
Semple JL, Gupta AK, From L, Harasiewicz KA, Sauder DN, Foster FS, Turnbull DH (1995) Does high-frequency (40–60 MHz) ultrasound imaging play a role in the clinical management of cutaneous melanoma? Ann Plast Surg 34:599–605
Serup J (1984) Decreased skin thickness of pigmented spots appearing in localized scleroderma (morphoea) - measurement of skin thickness by 15 MHz pulsed ultrasound. Arch Dermatol Res 276:135–137
Serup J, Staberg B (1987) Ultrasound for assessment of allergic and irritant patch test reactions. Contact Dermatitis 17:80–84
Solbiati L, Rizzatto G, Bellotti E (1988) High resolution sonography of cervical lymph nodes in head and neck cancer: Criteria for differentiation of reactive versus malignant lymph nodes. In: Proceedings of the 74th Meeting of the Radiologic Society of North America, Chicago. Radiology, 169: abstract 113ff
Stiller MJ, Gropper CA, Shupack JL, Lizzi F, Driller J, Rorke M (1994) Diagnostic ultrasound in dermatology: current uses and future potential. Cutis 53:44–48
Vaillant L, Berson M, Machet L, Callens A, Pourcelot L, Lorette G (1994) Ultrasound imaging of psoriatic skin: a non-invasive technique to evaluate treatment of psoriasis. Int J Dermatol 33:786–790
Vassallo P, Edel G, Roos N, Naguib A, Peters PE (1993) In-vitro high resolution ultrasonography of benign and malignant lymph nodes. A sonographic-pathologic correlation. Invest Radiol 28:698–705
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El Gammal, S., El Gammal, C., Altmeyer, P., Vogt, M. (2014). Sonography of the Skin. In: Berardesca, E., Maibach, H., Wilhelm, KP. (eds) Non Invasive Diagnostic Techniques in Clinical Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32109-2_13
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