Abstract
Pluripotency is a remarkable property, which is only transiently present during development. It is functionally defined by the capacity of a cell to differentiate into all cell lineages of an organism (cell types of the three embryonic germ layers, i.e., ecto-, endo-, and mesoderm, and the germ cell lineage) and to generate pluripotent daughter cells. It seems obvious that these special features of pluripotent cells must be reflected in molecular mechanisms regulating gene expression and chromatin structure. However, defining what are the mechanisms that control pluripotency and how are the unique features of pluripotent cells established, regulated, and maintained on the molecular level is a matter of intense research. Polycomb repressive complexes (PRCs) are key epigenetic regulators of development and cell specification. Here we summarize and discuss recent data on the role of PRC1 for the establishment and maintenance of embryonic stem (ES) cell pluripotency with special emphasis on the evolution of mammalian orthologs of PRC1 components.
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References
Akasaka T, Kanno M, Balling R, Mieza MA, Taniguchi M, Koseki H (1996) A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development 122:1513–1522
Akasaka T, Tsuji K, Kawahira H et al (1997) The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity 7:135–146
Akasaka T, van Lohuizen M, van der Lugt N et al (2001) Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development 128:1587–1597
Alkema MJ, Bronk M, Verhoeven E, Otte A, van ’t Veer LJ, Berns A, van Lohuizen M (1997) Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. Genes Dev 11:226–240
Avilion AA, Nicolis SK, Pevny LH, Perez L, Vivian N, Lovell-Badge R (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17:126–140. doi:10.1101/gad.224503
Bernstein BE, Mikkelsen TS, Xie X et al (2006) A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125:315–326. doi:10.1016/j.cell.2006.02.041
Bienz M, Muller J (1995) Transcriptional silencing of homeotic genes in Drosophila. Bioessays 17:775–784. doi:10.1002/bies.950170907
Blackledge NP, Farcas AM, Kondo T et al (2014) Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell 157:1445–1459. doi:10.1016/j.cell.2014.05.004
Boyer LA, Lee TI, Cole MF et al (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122:947–956. doi:10.1016/j.cell.2005.08.020
Boyer LA, Plath K, Zeitlinger J et al (2006) Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441:349–353. doi:10.1038/nature04733
Brown JP, Bullwinkel J, Baron-Luhr B, Billur M, Schneider P, Winking H, Singh PB (2010) HP1gamma function is required for male germ cell survival and spermatogenesis. Epigenetics Chromatin 3:9. doi:10.1186/1756-8935-3-9
Caillier M, Thenot S, Tribollet V, Birot AM, Samarut J, Mey A (2010) Role of the epigenetic regulator HP1gamma in the control of embryonic stem cell properties. PLoS One 5:e15507. doi:10.1371/journal.pone.0015507
Chamberlain SJ, Yee D, Magnuson T (2008) Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency. Stem Cells 26:1496–1505. doi:10.1634/stemcells.2008-0102
Chambers I, Smith A (2004) Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 23:7150–7160. doi:10.1038/sj.onc.1207930
Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113:643–655
Chambers I, Silva J, Colby D et al (2007) Nanog safeguards pluripotency and mediates germline development. Nature 450:1230–1234. doi:10.1038/nature06403
Chew JL, Loh YH, Zhang W et al (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25:6031–6046. doi:10.1128/MCB.25.14.6031-6046.2005
Christophersen NS, Helin K (2010) Epigenetic control of embryonic stem cell fate. J Exp Med 207:2287–2295. doi:10.1084/jem.20101438
Cole MF, Young RA (2008) Mapping key features of transcriptional regulatory circuitry in embryonic stem cells. Cold Spring Harb Symp Quant Biol 73:183–193. doi:10.1101/sqb.2008.73.027
Core N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A, Djabali M (1997) Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 124:721–729
Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V (2002) Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111:185–196
de Napoles M, Mermoud JE, Wakao R et al (2004) Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell 7:663–676. doi:10.1016/j.devcel.2004.10.005
del Mar LM, Marcos-Gutierrez C, Perez C, Schoorlemmer J, Ramirez A, Magin T, Vidal M (2000) Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice. Development 127:5093–5100
Dovey OM, Foster CT, Cowley SM (2010) Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl Acad Sci U S A 107:8242–8247. doi:10.1073/pnas.1000478107
Duncan IM (1982) Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster. Genetics 102:49–70
Endoh M, Endo TA, Endoh T et al (2008) Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. Development 135:1513–1524. doi:10.1242/dev.014340
Finn RD, Bateman A, Clements J et al (2014) Pfam: the protein families database. Nucleic Acids Res 42:D222–D230. doi:10.1093/nar/gkt1223
Fischle W, Wang Y, Jacobs SA, Kim Y, Allis CD, Khorasanizadeh S (2003) Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev 17:1870–1881. doi:10.1101/gad.1110503
Forzati F, Federico A, Pallante P et al (2012) CBX7 is a tumor suppressor in mice and humans. J Clin Invest 122:612–623. doi:10.1172/JCI58620
Francis NJ, Saurin AJ, Shao Z, Kingston RE (2001) Reconstitution of a functional core polycomb repressive complex. Mol Cell 8:545–556
Francis NJ, Kingston RE, Woodcock CL (2004) Chromatin compaction by a polycomb group protein complex. Science 306:1574–1577. doi:10.1126/science.1100576
Franke A, DeCamillis M, Zink D, Cheng N, Brock HW, Paro R (1992) Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J 11:2941–2950
Fukuda T, Tokunaga A, Sakamoto R, Yoshida N (2011) Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol Cell Neurosci 46:614–624. doi:10.1016/j.mcn.2011.01.001
Gao Z, Zhang J, Bonasio R et al (2012) PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell 45:344–356. doi:10.1016/j.molcel.2012.01.002
Garcia E, Marcos-Gutierrez C, del Mar LM, Moreno JC, Vidal M (1999) RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J 18:3404–3418. doi:10.1093/emboj/18.12.3404
Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ (2006) Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol 26:6880–6889. doi:10.1128/MCB.00630-06
Gould A (1997) Functions of mammalian Polycomb group and trithorax group related genes. Curr Opin Genet Dev 7:488–494
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P (2010) Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell 18:675–685. doi:10.1016/j.devcel.2010.02.012
Hailesellasse Sene K, Porter CJ, Palidwor G et al (2007) Gene function in early mouse embryonic stem cell differentiation. BMC Genomics 8:85. doi:10.1186/1471-2164-8-85
Hekimoglu B, Ringrose L (2009) Non-coding RNAs in polycomb/trithorax regulation. RNA Biol 6:129–137
Hekimoglu-Balkan B, Aszodi A, Heinen R, Jaritz M, Ringrose L (2012) Intergenic Polycomb target sites are dynamically marked by non-coding transcription during lineage commitment. RNA Biol 9:314–325. doi:10.4161/rna.19102
Hisada K, Sanchez C, Endo TA et al (2012) RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells. Mol Cell Biol 32:1139–1149. doi:10.1128/MCB.06441-11
Hishida T, Nozaki Y, Nakachi Y et al (2011) Indefinite self-renewal of ESCs through Myc/Max transcriptional complex-independent mechanisms. Cell Stem Cell 9:37–49. doi:10.1016/j.stem.2011.04.020
Isono K, Fujimura Y, Shinga J et al (2005) Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Mol Cell Biol 25:6694–6706. doi:10.1128/MCB.25.15.6694-6706.2005
Jacobs JJ, van Lohuizen M (1999) Cellular memory of transcriptional states by Polycomb-group proteins. Semin Cell Dev Biol 10:227–235. doi:10.1006/scdb.1999.0304
Jacobs JJ, van Lohuizen M (2002) Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim Biophys Acta 1602:151–161
Jones CA, Ng J, Peterson AJ, Morgan K, Simon J, Jones RS (1998) The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression. Mol Cell Biol 18:2825–2834
Jürgens G (1985) A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature 316:153–155. doi:10.1038/316153a0
Kashyap V, Rezende NC, Scotland KB, Shaffer SM, Persson JL, Gudas LJ, Mongan NP (2009) Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev 18:1093–1108. doi:10.1089/scd.2009.0113
Katoh-Fukui Y, Tsuchiya R, Shiroishi T, Nakahara Y, Hashimoto N, Noguchi K, Higashinakagawa T (1998) Male-to-female sex reversal in M33 mutant mice. Nature 393:688–692. doi:10.1038/31482
Katoh-Fukui Y, Owaki A, Toyama Y et al (2005) Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression. Blood 106:1612–1620. doi:10.1182/blood-2004-08-3367
Katoh-Fukui Y, Miyabayashi K, Komatsu T et al (2012) Cbx2, a polycomb group gene, is required for Sry gene expression in mice. Endocrinology 153:913–924. doi:10.1210/en.2011-1055
Kerppola TK (2009) Polycomb group complexes–many combinations, many functions. Trends Cell Biol 19:692–704. doi:10.1016/j.tcb.2009.10.001
Klymenko T, Muller J (2004) The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins. EMBO Rep 5:373–377. doi:10.1038/sj.embor.7400111
Kohn MJ, Bronson RT, Harlow E, Dyson NJ, Yamasaki L (2003) Dp1 is required for extra-embryonic development. Development 130:1295–1305
Kyba M, Brock HW (1998) The Drosophila polycomb group protein Psc contacts ph and Pc through specific conserved domains. Mol Cell Biol 18:2712–2720
Lagger G, O’Carroll D, Rembold M et al (2002) Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J 21:2672–2681. doi:10.1093/emboj/21.11.2672
Lee TI, Jenner RG, Boyer LA et al (2006) Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125:301–313. doi:10.1016/j.cell.2006.02.043
Leeb M, Wutz A (2007) Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells. J Cell Biol 178:219–229. doi:10.1083/jcb.200612127
Leeb M, Pasini D, Novatchkova M, Jaritz M, Helin K, Wutz A (2010) Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev 24:265–276. doi:10.1101/gad.544410
Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (2002) The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol 22:6070–6078
Lewis EB (1978) A gene complex controlling segmentation in Drosophila. Nature 276:565–570
Liu J, Cao L, Chen J et al (2009) Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 459:387–392. doi:10.1038/nature08040
Liu B, Liu YF, Du YR et al (2013) Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development 140:780–788. doi:10.1242/dev.085035
Loh YH, Wu Q, Chew JL et al (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38:431–440. doi:10.1038/ng1760
Maeda I, Okamura D, Tokitake Y et al (2013) Max is a repressor of germ cell-related gene expression in mouse embryonic stem cells. Nat Commun 4:1754. doi:10.1038/ncomms2780
Mah N, Wang Y, Liao MC et al (2011) Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network. PLoS One 6:e24351. doi:10.1371/journal.pone.0024351
Marks H, Kalkan T, Menafra R et al (2012) The transcriptional and epigenomic foundations of ground state pluripotency. Cell 149:590–604. doi:10.1016/j.cell.2012.03.026
Martinez AM, Cavalli G (2006) The role of polycomb group proteins in cell cycle regulation during development. Cell Cycle 5:1189–1197
Masui S, Nakatake Y, Toyooka Y et al (2007) Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 9:625–635. doi:10.1038/ncb1589
Min J, Zhang Y, Xu RM (2003) Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev 17:1823–1828. doi:10.1101/gad.269603
Mitsui K, Tokuzawa Y, Itoh H et al (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113:631–642
Mohd-Sarip A, Lagarou A, Doyen CM et al (2012) Transcription-independent function of Polycomb group protein PSC in cell cycle control. Science 336:744–747. doi:10.1126/science.1215927
Montgomery RL, Davis CA, Potthoff MJ et al (2007) Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev 21:1790–1802. doi:10.1101/gad.1563807
Moon JH, Heo JS, Kim JS et al (2011) Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1. Cell Res 21:1305–1315. doi:10.1038/cr.2011.107
Morey L, Pascual G, Cozzuto L, Roma G, Wutz A, Benitah SA, Di Croce L (2012) Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells. Cell Stem Cell 10:47–62. doi:10.1016/j.stem.2011.12.006
Muller J, Kassis JA (2006) Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Curr Opin Genet Dev 16:476–484. doi:10.1016/j.gde.2006.08.005
Muller J, Hart CM, Francis NJ et al (2002) Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111:197–208
NCBI (2014) Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 42:D7–D17. doi:10.1093/nar/gkt1146
Nekrasov M, Klymenko T, Fraterman S et al (2007) Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J 26:4078–4088. doi:10.1038/sj.emboj.7601837
Nichols J, Smith A (2011) The origin and identity of embryonic stem cells. Development 138:3–8. doi:10.1242/dev.050831
Nichols J, Zevnik B, Anastassiadis K et al (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95:379–391
Niwa H (2007) How is pluripotency determined and maintained? Development 134:635–646. doi:10.1242/dev.02787
Niwa H, Miyazaki J, Smith AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24:372–376. doi:10.1038/74199
Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, Rossant J (2005) Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123:917–929. doi:10.1016/j.cell.2005.08.040
Ohta H, Sawada A, Kim JY et al (2002) Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells. J Exp Med 195:759–770
Okumura-Nakanishi S, Saito M, Niwa H, Ishikawa F (2005) Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. J Biol Chem 280:5307–5317. doi:10.1074/jbc.M410015200
O’Loghlen A, Munoz-Cabello AM, Gaspar-Maia A et al (2012) MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell 10:33–46. doi:10.1016/j.stem.2011.12.004
Onder TT, Kara N, Cherry A et al (2012) Chromatin-modifying enzymes as modulators of reprogramming. Nature 483:598–602. doi:10.1038/nature10953
Orlando V, Paro R (1995) Chromatin multiprotein complexes involved in the maintenance of transcription patterns. Curr Opin Genet Dev 5:174–179
Papp B, Plath K (2011) Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape. Cell Res 21:486–501. doi:10.1038/cr.2011.28
Peitz M, Munst B, Thummer RP, Helfen M, Edenhofer F (2014) Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification. Stem Cell Res 12:680–689. doi:10.1016/j.scr.2014.02.006
Perez-Iratxeta C, Palidwor G, Porter CJ et al (2005) Study of stem cell function using microarray experiments. FEBS Lett 579:1795–1801. doi:10.1016/j.febslet.2005.02.020
Pesce M, Scholer HR (2000) Oct-4: control of totipotency and germline determination. Mol Reprod Dev 55:452–457. doi:10.1002/(SICI)1098-2795(200004)55:4<452::AID-MRD14>3.0.CO;2-S
Pirity MK, Locker J, Schreiber-Agus N (2005) Rybp/DEDAF is required for early postimplantation and for central nervous system development. Mol Cell Biol 25:7193–7202. doi:10.1128/MCB.25.16.7193-7202.2005
Pirity MK, Wang WL, Wolf LV, Tamm ER, Schreiber-Agus N, Cvekl A (2007) Rybp, a polycomb complex-associated protein, is required for mouse eye development. BMC Dev Biol 7:39. doi:10.1186/1471-213X-7-39
Poux S, Horard B, Sigrist CJ, Pirrotta V (2002) The Drosophila trithorax protein is a coactivator required to prevent re-establishment of polycomb silencing. Development 129:2483–2493
Prezioso C, Orlando V (2011) Polycomb proteins in mammalian cell differentiation and plasticity. FEBS Lett 585:2067–2077. doi:10.1016/j.febslet.2011.04.062
Qin J, Whyte WA, Anderssen E et al (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11:319–332. doi:10.1016/j.stem.2012.06.002
Ringrose L, Paro R (2004) Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet 38:413–443. doi:10.1146/annurev.genet.38.072902.091907
Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, Robson P (2005) Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem 280:24731–24737. doi:10.1074/jbc.M502573200
Rose PW, Bi C, Bluhm WF et al (2013) The RCSB Protein Data Bank: new resources for research and education. Nucleic Acids Res 41:D475–D482. doi:10.1093/nar/gks1200
Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F, Rigby PW, Staudt LM (1990) A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345:686–692. doi:10.1038/345686a0
Sanchez C, Sanchez I, Demmers JA, Rodriguez P, Strouboulis J, Vidal M (2007) Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics 6:820–834. doi:10.1074/mcp.M600275-MCP200
Satijn DP, Otte AP (1999) Polycomb group protein complexes: do different complexes regulate distinct target genes? Biochim Biophys Acta 1447:1–16
Schaefer MH, Fontaine JF, Vinayagam A, Porras P, Wanker EE, Andrade-Navarro MA (2012) HIPPIE: integrating protein interaction networks with experiment based quality scores. PLoS One 7:e31826. doi:10.1371/journal.pone.0031826
Schaefer MH, Lopes TJ, Mah N et al (2013) Adding protein context to the human protein-protein interaction network to reveal meaningful interactions. PLoS Comput Biol 9:e1002860. doi:10.1371/journal.pcbi.1002860
Schoeftner S, Sengupta AK, Kubicek S et al (2006) Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J 25:3110–3122. doi:10.1038/sj.emboj.7601187
Scholer HR, Ruppert S, Suzuki N, Chowdhury K, Gruss P (1990) New type of POU domain in germ line-specific protein Oct-4. Nature 344:435–439. doi:10.1038/344435a0
Schuettengruber B, Cavalli G (2009) Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development 136:3531–3542. doi:10.1242/dev.033902
Schwartz YB, Pirrotta V (2007) Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet 8:9–22. doi:10.1038/nrg1981
Schwartz YB, Kahn TG, Nix DA, Li XY, Bourgon R, Biggin M, Pirrotta V (2006) Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet 38:700–705. doi:10.1038/ng1817
Sewalt RG, van der Vlag J, Gunster MJ et al (1998) Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. Mol Cell Biol 18:3586–3595
Shafa M, Krawetz R, Rancourt DE (2010) Returning to the stem state: epigenetics of recapitulating pre-differentiation chromatin structure. Bioessays 32:791–799. doi:10.1002/bies.201000033
Shao Z, Raible F, Mollaaghababa R, Guyon JR, Wu CT, Bender W, Kingston RE (1999) Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 98:37–46. doi:10.1016/S0092-8674(00)80604-2
Shen-Li H, O’Hagan RC, Hou H Jr, Horner JW II, Lee HW, DePinho RA (2000) Essential role for Max in early embryonic growth and development. Genes Dev 14:17–22
Shirai M, Osugi T, Koga H et al (2002) The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. J Clin Invest 110:177–184. doi:10.1172/JCI14839
Silva J, Barrandon O, Nichols J, Kawaguchi J, Theunissen TW, Smith A (2008) Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol 6:e253. doi:10.1371/journal.pbio.0060253
Simon JA, Kingston RE (2009) Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol 10:697–708. doi:10.1038/nrm2763
Sparmann A, van Lohuizen M (2006) Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6:846–856. doi:10.1038/nrc1991
Stock JK, Giadrossi S, Casanova M et al (2007) Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol 9:1428–1435. doi:10.1038/ncb1663
Storre J, Elsasser HP, Fuchs M, Ullmann D, Livingston DM, Gaubatz S (2002) Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6. EMBO Rep 3:695–700. doi:10.1093/embo-reports/kvf141
Struhl G (1981) A gene product required for correct initiation of segmental determination in Drosophila. Nature 293:36–41
Strutt H, Paro R (1997) The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes. Mol Cell Biol 17:6773–6783
Surface LE, Thornton SR, Boyer LA (2010) Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell 7:288–298. doi:10.1016/j.stem.2010.08.004
Suzuki M, Mizutani-Koseki Y, Fujimura Y et al (2002) Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129:4171–4183
Takihara Y, Tomotsune D, Shirai M et al (1997) Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development 124:3673–3682
Tavares L, Dimitrova E, Oxley D et al (2012) RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell 148:664–678. doi:10.1016/j.cell.2011.12.029
Tie F, Furuyama T, Harte PJ (1998) The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites. Development 125:3483–3496
Torres J, Watt FM (2008) Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. Nat Cell Biol 10:194–201. doi:10.1038/ncb1680
van der Lugt NM, Domen J, Linders K et al (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8:757–769
van der Stoop P, Boutsma EA, Hulsman D et al (2008) Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells. PLoS One 3:e2235. doi:10.1371/journal.pone.0002235
van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T, Wientjens E (1998) Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol 18:3572–3579
Vandamme J, Volkel P, Rosnoblet C, Le Faou P, Angrand PO (2011) Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics 10(M110):002642. doi:10.1074/mcp.M110.002642
Voncken JW, Roelen BA, Roefs M et al (2003) Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci U S A 100:2468–2473. doi:10.1073/pnas.0434312100
Wamstad JA, Corcoran CM, Keating AM, Bardwell VJ (2008) Role of the transcriptional corepressor Bcor in embryonic stem cell differentiation and early embryonic development. PLoS One 3:e2814. doi:10.1371/journal.pone.0002814
Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y (2004) Role of histone H2A ubiquitination in Polycomb silencing. Nature 431:873–878. doi:10.1038/nature02985
Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH (2006) A protein interaction network for pluripotency of embryonic stem cells. Nature 444:364–368. doi:10.1038/nature05284
Wang R, Taylor AB, Leal BZ et al (2010a) Polycomb group targeting through different binding partners of RING1B C-terminal domain. Structure 18:966–975. doi:10.1016/j.str.2010.04.013
Wang Y, Mah N, Prigione A, Wolfrum K, Andrade-Navarro MA, Adjaye J (2010b) A transcriptional roadmap to the induction of pluripotency in somatic cells. Stem Cell Rev 6:282–296. doi:10.1007/s12015-010-9137-2
Whitcomb SJ, Basu A, Allis CD, Bernstein E (2007) Polycomb Group proteins: an evolutionary perspective. Trends Genet 23:494–502. doi:10.1016/j.tig.2007.08.006
Wu X, Johansen JV, Helin K (2013) Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol Cell 49:1134–1146. doi:10.1016/j.molcel.2013.01.016
Ying QL, Wray J, Nichols J et al (2008) The ground state of embryonic stem cell self-renewal. Nature 453:519–523. doi:10.1038/nature06968
Young RA (2011) Control of the embryonic stem cell state. Cell 144:940–954. doi:10.1016/j.cell.2011.01.032
Yu M, Mazor T, Huang H et al (2012) Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell 45:330–343. doi:10.1016/j.molcel.2011.11.032
Zencak D, Lingbeek M, Kostic C et al (2005) Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation. J Neurosci 25:5774–5783. doi:10.1523/JNEUROSCI.3452-04.2005
Zhou W, Zhu P, Wang J et al (2008) Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell 29:69–80. doi:10.1016/j.molcel.2007.11.002
Acknowledgment
We are grateful to Nadine Obier and Stanislaw Gorski for discussions and critical reading of the manuscript. This work was supported by research grants from the DFG SPP1356, the DFG SPP1463, and the graduate college 1048.
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Becker, M. et al. (2015). PRC1-Mediated Gene Silencing in Pluripotent ES Cells: Function and Evolution. In: Meissner, A., Walter, J. (eds) Epigenetic Mechanisms in Cellular Reprogramming. Epigenetics and Human Health. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31974-7_7
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