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Genomics in the Sea Urchin: New Perspectives on a Perennial Model System

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Genome Mapping and Genomics in Laboratory Animals

Part of the book series: Genome Mapping and Genomics in Animals ((MAPPANIMAL,volume 4))

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Abstract

The first genome sequenced from an echinoderm was completed from the purple sea urchin, Strongylocentrotus purpuratus, as part of the Sea Urchin Genome Project. Here, we describe how this resource has synergized with the long-standing repertoire of experimental techniques developed for the sea urchin over the last century to position the sea urchin as a key model organism for studying modern genome biology. The Sea Urchin Genome Project continues to advance studies in this phylum, as genomes from six additional echinoderms are currently at various stages of sequencing. These species were selected to cover a broad phylogenetic distribution and comprise a set of sequences for powerful comparative analyses. In combination with its rich catalog of experimental methods, the genome sequence provides a framework for addressing question in gene regulatory network biology within a deuterostome model that has close affinities to vertebrates. Furthermore, this invertebrate genome sequence samples an entirely new branch of animal phylogeny, and the biology implied by the complexity of what it encodes reveals unprecedented directions of animal evolution.

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Acknowledgments

We thank R. Andrew Cameron and members of the wider sea urchin community for enlightening discussions. This work is supported by grants from the Canadian Institutes for Health Research (MOP74667) and the Natural Sciences and Engineering Research Council of Canada (NSERC 312221) to JPR.

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  1. Department of Medical Biophysics and Department of Immunology, University of Toronto, Toronto, Canada

    Katherine M. Buckley & Jonathan P. Rast

  2. Sunnybrook Research Institute, 2075 Bayview Avenue, Room S126B, Toronto, ON, Canada, M4N3M5

    Katherine M. Buckley & Jonathan P. Rast

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  1. Katherine M. Buckley
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Correspondence to Jonathan P. Rast .

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  1. Mammalian Genetics Unit, Medical Research Council Harwell, Oxfordshire, OX11 0RD, United Kingdom

    Paul Denny

  2. Institute of Nutraceutical Research, Clemson University, Jordan Hall 109, Clemson, 29634, South Carolina, USA

    Chittaranjan Kole

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Buckley, K.M., Rast, J.P. (2012). Genomics in the Sea Urchin: New Perspectives on a Perennial Model System. In: Denny, P., Kole, C. (eds) Genome Mapping and Genomics in Laboratory Animals. Genome Mapping and Genomics in Animals, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31316-5_1

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