Abstract
In this chapter we present the design fundamentals on the development of magnetic nanoparticle systems to become suitable for biomedical applications, from the most used strategies for chemical synthesis and surface functionalization to their main researched applications in the biomedical field nowadays. Special attention has been paid on magnetic resonance imaging and magnetically induced hyperthermia. A revision and recent advances on these fields will be shown.
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References
Ko SH, Park I, Pan H, Grigoropoulos CP, Pisano AP, Luscombe CK, Fréchet JMJ (2007) Direct nanoimprinting of metal nanoparticles for nanoscale electronics fabrication. Nano Lett 7(7):1869
Gibson RF (2010) A review of recent research on mechanics of multifunctional composite materials and structures. Compos Struct 92:2793
Bañobre-López M, Piñeiro-Redondo Y, De Santis R, Gloria A, Ambrosio L, Tampieri A, Dediu V, Rivas J (2011) Poly(caprolactone) based magnetic scaffolds for bone tissue engineering. J Appl Phys 109:07B313
Rivas J, Bañobre-López M, Piñeiro-Redondo Y, Rivas B, López-Quintela MA (2012) Magnetic nanoparticles for application in cancer therapy. J Magn Magn Mater 324:3499
Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 108(6):2064
Hadjipanayis CG, Bonder MJ, Balakrishnan S, Wang X, Mao H, Hadjipanayis GC (2008) Metallic iron nanoparticles for MRI contrast enhancement and local hyperthermia. Small 4(11):1925
Langer R (1990) New methods of drug delivery. Science 249(4976):1527
Bulte JWM, Modo MMJ (eds) (2008) Nanoparticles in biomedical imaging – emerging 1009 technologies and applications. Springer, New York
Lu AH, Salabas EL, Schüth F (2007) Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed 46(8):1222
Salgueiriño-Maceira V, Correa-Duarte MA (2007) Increasing the complexity of magnetic core/shell structured nanocomposites for biological applications. Adv Mater 19(23):4131
LaMer VK, Dinegar RH (1950) Theory, production and mechanism of formation of monodispersed hydrosols. J Am Chem Soc 72(11):4847
den Ouden CJJ, Thompson RW (1991) Analysis of the formation of monodisperse populations by homogeneous nucleation. J Colloid Interface Sci 143(1):77
Sugimoto T, Matijevic E (1980) Formation of uniform spherical magnetite particles by crystallization from ferrous hydroxide gels. J Colloid Interface Sci 74(1):227
Ocaña M, Rodriguez-Clemente R, Serna CJ (1995) Uniform colloidal particles in solution: formation mechanisms. Adv Mater 7(2):212
Lee J-H, Huh Y-M, Y-w J, J-w S, J-t J, Song H-T, Kim S, Cho E-J, Yoon H-G, Suh J-S, Cheon J (2007) Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat Med 13:95
Cushing BL, Kolesnichenko VL, O’Connor CJ (2004) Recent advances in the liquid-phase syntheses of inorganic nanoparticles. Chem Rev 104(9):3893
Piñeiro-Redondo Y, Bañobre-López M, Pardiñas-Blanco I, Goya G, López-Quintela MA, Rivas J (2011) The influence of colloidal parameters on the specific power absorption of PAA-coated magnetite nanoparticles. Nano Res Lett 6:383
Zhang Y, Kohler N, Zhang M (2002) Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. Biomaterials 23(7):1553
Petri-Fink A, Chastellain M, Juillerat-Jeanneret L, Ferrari A, Hofmann H (2005) Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells. Biomaterials 26(15):2685
D’Souza AJM, Schowen RL, Topp EM (2004) Polyvinylpyrrolidone-drug conjugate: synthesis and release mechanism. J Control Release 94(1):91
Berry CC, Wells S, Charles S, Aitchison G, Curtis ASG (2004) Cell response to dextran-derivatised iron oxide nanoparticles post internalisation. Biomaterials 25(23):5405
Bergemann C, Müller-Schulte D, Oster J, Brassard L, Lübbe AS (1999) Magnetic ion-exchange nano- and microparticles for medical, biochemical and molecular biological applications. J Magn Magn Mater 194(1–3):45
Rodríguez C, Bañobre-López M, Kolen’ko YV, Rodríguez B, Freitas P, Rivas J (2012) Magnetization drop at high temperature in oleic acid-coated magnetite nanoparticles. IEEE Trans Magn 48(11):3307
Hyeon T, Lee SS, Park J, Chung Y, Na HB (2001) Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process. J Am Chem Soc 123(51):12798
Sun S, Zeng H (2002) Size-controlled synthesis of magnetite nanoparticles. J Am Chem Soc 124(28):8204
Sun S, Zeng H, Robinson DB, Raoux S, Rice PM, Wang SX, Li G (2004) Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles. J Am Chem Soc 126(1):273
Park J, An K, Hwang Y, Park J-G, Noh H-J, Kim J-Y, Park J-H, Hwang N-M, Hyeon T (2004) Ultra-large-scale syntheses of monodisperse nanocrystals. Nat Mater 3(12):891
Li Z, Sun Q, Gao M (2005) Preparation of water-soluble magnetite nanocrystals from hydrated ferric salts in 2-pyrrolidone: mechanism leading to Fe3O4. Angew Chem Int Ed 44(1):123
Hu F, Wei L, Zhou Z, Ran YL, Li Z, Gao M (2006) Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer. Adv Mater 18(19):2553
López-Quintela MA, Rivas J (1993) Chemical reactions in microemulsions: a powerful method to obtain ultrafine particles. J Colloid Interface Sci 158(2):446
López-Quintela MA, Rivas J (1996) Nanoscale magnetic particles: synthesis, structure and dynamics. Curr Opinion Colloid Interface Sci 1(6):806
López-Quintela MA, Rivas J, Blanco MC, Tojo C (2003) Synthesis of nanoparticles in microemulsions. In: Liz Marzán LM, Kamat PV (eds) Nanoscale materials, vol 6. Kluwer Academic Plenum, Dordrecht, Netherlands, p 135
López-Quintela MA (2003) Synthesis of nanomaterials in microemulsions: formation mechanisms and growth control. Curr Opin Colloid Interface Sci 8(2):137
Boutonnet M, Kizling J, Stenius P (1982) The preparation of monodisperse colloidal metal particles from microemulsions. Colloids Surf A: Physicochem Eng Aspects 5(3):209
Woo K, Lee HJ, Ahn J-P, Park YS (2003) Sol–gel mediated synthesis of Fe2O3 Nanorods. Adv Mater 15(20):1761
Vidal J, Rivas J, López-Quintela MA (2006) Synthesis of monodisperse maghemite nanoparticles by the microemulsion method. Colloids Surf A Physicochem Eng Asp 288(1–3):44
López-Pérez JA, López-Quintela MA, Mira J, Rivas J, Charles SW (1997) Advances in the preparation of magnetic nanoparticles by the microemulsion method. J Phys Chem B 101(41):8045
Wang X, Zhuang J, Peng Q, Li Y (2005) A general strategy for nanocrystal synthesis. Nature 437(7055):121
Deng H, Li X, Peng Q, Wang X, Chen J, Li Y (2005) Monodisperse magnetic single-crystal ferrite microspheres. Angew Chem Int Ed Engl 44(18):2782
Tartaj P, del Puerto-Morales M, Veintemillas-Verdaguer S, González-Carreño SCJ (2003) The preparation of magnetic nanoparticles for applications in biomedicine. J Phys D: Appl Phys 36:R182
Denizot B, Tanguy G, Hindre F, Rump E, Lejeune JJ, Jallet P (1999) Phosphorylcholine coating of iron oxide nanoparticles. J Colloid Interface Sci 209(1):66
Hansen T, Clermont G, Alves A, Eloy R, Brochhausen C, Boutrand JP, Gatti AM, Kirkpatrick CJ (2006) Biological tolerance of different materials in bulk and nanoparticulate form in a rat model: sarcoma development by nanoparticles. J R Soc Interface 3(11):767
Ahamed M (2011) Toxic response of nickel nanoparticles in human lung epithelial A549 cells. Toxicol In Vitro 25(4):930
Mehdaoui B, Meffre A, Lacroix L-M, Carrey J, Lachaize S, Gougeon M, Respaud M, Chaudret B (2010) Large specific absorption rates in the magnetic hyperthermia properties of metallic iron nanocubes. J Magn Magn Mater 322(19):L49
Deng M, Tu N, Bai F, Wang L (2012) Surface functionalization of hydrophobic nanocrystals with one particle per micelle for bioapplications. Chem Mater 24(13):2592
Euliss LE, Grancharov SG, O’Brien S, Deming TJ, Stucky GD, Murray CB, Held GA (2003) Cooperative assembly of magnetic nanoparticles and block copolypeptides in aqueous media. Nano Lett 3(11):1489
Liu X, Guan Y, Ma Z, Liu H (2004) Surface modification and characterization of magnetic polymer nanospheres prepared by miniemulsion polymerization. Langmuir 20(23):10278
Hong R, Fischer NO, Emrick T, Rotello VM (2005) Surface PEGylation and ligand exchange chemistry of FePt nanoparticles for biological applications. Chem Mater 17(18):4617
Sahoo Y, Pizem H, Fried T, Golodnitsky D, Burstein L, Sukenik CN, Markovich G (2001) Alkyl phosphonate/phosphate coating on magnetite nanoparticles: a comparison with fatty acids. Langmuir 17(25):7907
Kim M, Chen Y, Liu Y, Peng X (2005) Super-stable, high-quality Fe3O4 dendron–nanocrystals dispersible in both organic and aqueous solutions. Adv Mater 17(11):1429
Kobayasi Y, Horie M, Konno M, Rodriguez-Gonzalez B, Liz-Marzan LM (2003) Preparation and properties of silica-coated cobalt nanoparticles. J Phys Chem B 107(30):7420
Lu Y, Yin Y, Mayers T, Xia Y (2002) Modifying the surface properties of superparamagnetic iron oxide nanoparticles through a sol−gel approach. Nano Lett 2(3):183
Liu Q, Xu Z, Finch JA, Egerton R (1998) A novel two-step silica-coating process for engineering magnetic nanocomposites. Chem Mater 10(12):3936
Cheong S, Ferguson P, Hermans IF, Jameson GNL, Prabakar S, Herman DAJ, Tilley RD (2012) Synthesis and stability of highly crystalline and stable iron/iron oxide core/shell nanoparticles for biomedical applications. Chem Plus Chem 77(2):135
Shen L, Laibinis PE, Hatton TA (1999) Bilayer surfactant stabilized magnetic fluids: synthesis and interactions at interfaces. Langmuir 15(2):447
Massart R (1981) Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE Trans Magn MAG-17:1247
Deng J, Ding X, Zhang W, Peng Y, Wang J, Long X, Li P, Chan ASC (2002) Magnetic and conducting Fe3O4-cross-linked polyaniline nanoparticles with core-shell structure. Polymer 43:2179
Vestal CR, Zhang ZJ (2002) Effects of surface coordination chemistry on the magnetic properties of MnFe(2)O(4) spinel ferrite nanoparticles. J Am Chem Soc 124:14312
Dresco PA, Zaitsev VS, Gambino RJ, Chu B (1999) Preparation and properties of magnetite and polymer magnetite nanoparticles. Langmuir 15:1945
Schladt TD, Schneider K, Schild H, Tremel W (2011) Synthesis and bio-functionalization of magnetic nanoparticles for medical diagnosis and treatment. Dalton Trans 40:6315
Xu Z, Hou Y, Sun S (2007) Magnetic core/shell Fe3O4/Au and Fe3O4/Au/Ag nanoparticles with tunable plasmonic properties. J Am Chem Soc 129:8698
Stöber W, Fink A, Bohn EJ (1968) Controlled growth of monodisperse silica spheres in the micron size range. J Colloid Interface Sci 26:62
Tago T, Hatsuta T, Miyajima K, Kishida M, Tashiro S, Wakabayashi K (2002) Novel synthesis of silica-coated ferrite nanoparticles prepared using water-in-oil microemulsion. J Am Ceram Soc 85:2188
Medintz IL, Stewart MH, Trammell SA, Susumu K, Delehanty JB, Mei BC, Melinger JS, Blanco-Canosa JB, Dawson PE, Mattoussi H (2010) Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing. Nat Mater 9:676
Dong A, Ye X, Chen J, Kang Y, Gordon T, Kikkawa JM, Murray CB (2011) A generalized ligand-exchange strategy enabling sequential surface functionalization of colloidal nanocrystals. J Am Chem Soc 133:998
Erathodiyil N, Ying JY (2011) Functionalization of inorganic nanoparticles for bioimaging applications. Acc Chem Res 44:925
Pileni MP (2001) Magnetic fluids: fabrication, magnetic properties, and organization of nanocrystals. Adv Func Mater 11(5):323
Sun SH, Zeng H, Robinson DB, Raoux S, Rice PM, Wang SX, Li GX (2004) Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles. J Am Chem Soc 126(1):273
Lattuada M, Alan Hatton T (2007) Functionalization of monodisperse magnetic nanoparticles. Langmuir 23:2158
von Werne T, Patten TE (2001) Atom transfer radical polymerization from nanoparticles: a tool for the preparation of well-defined hybrid nanostructures and for understanding the chemistry of controlled/“living” radical polymerizations from surfaces. J Am Chem Soc 123(31):7497
Marutani E, Yamamoto S, Ninjbadgar T, Tsujii Y, Fukuda T, Takano M (2004) Surface-initiated atom transfer radical polymerization of methyl mthacrylate on magnetic nanoparticles. Polymer 45(7):3321
Schmidt AM (2005) Magnetic core-shell nanoparticles by surface-initiated ring-opening polymerization of e-caprolactone. Macromol Rapid Commun 26(2):93
Wang B, Xu C, Xie J, Yang Z, Sun S (2008) pH controlled release of chromone from chromone-Fe3O4 nanoparticles. J Am Chem Soc 130:14436
Frey NA, Peng S, Cheng K, Sun S (2009) Magnetic nanoparticles: synthesis, functionalization, and applications in bioimaging and magnetic energy storage. Chem Soc Rev 38:2532
Xie J, Chen K, Lee H-Y, Xu C, Hsu AR, Peng S, Chen X, Sun S (2008) Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin αvβ3-rich tumor cells. J Am Chem Soc 130:7542
Ma X, Zhao Y, Liang X-J (2011) Theranostic nanoparticles engineered for clinic and pharmaceutics. Acc Chem Res 44(10):1114
Lübbe AS, Bergemann C, Riess H, Schriever F, Reichardt P, Possinger K, Matthias M, Dörken B, Herrmann F, Gürtler R, Hohenberger P, Haas N, Sohr R, Sander B, Lemke A-J, Ohlendorf D, Huhnt W, Huhn D (1996) Clinical experiences with magnetic drug targeting: a phase I study with 4′-epidoxorubicin in 14 patients with advanced solid tumors. Cancer Res 56:4686
Na HB, Song IC, Hyeon T (2009) Inorganic nanoparticles for MRI contrast agents. Adv Mater 21(21):2133
Caravan P, Ellison JJ, McMurry TJ, Lauffer RB (1999) Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications. Chem Rev 99:2293
Sun C, Du K, Fang C, Bhattarai N, Veiseh O, Kievit F, Stephen Z, Lee D, Zhang M (2010) PEG-mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: their physicochemical properties and function in vivo. ACS Nano 4(4):2402
Pankhurst QA, Connolly J, Jones SK, Dobson J (2003) Applications of magnetic nanoparticles in biomedicine. J Phys D: Appl Phys 36:R167
Stephen ZR, Kievit FM, Zhang M (2011) Magnetite nanoparticles for medical MR imaging. Mater Today 14:330
Corot C, Robert P, Idee JM, Port M (2006) Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Deliver Rev 58:1471
Sun C, Lee JSH, Zhang M (2008) Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliver Rev 60:1252
Bae KH, Lee K, Kim C, Park TG (2011) Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging. Biomaterials 32(1):176
Yang H, Zhuang Y, Sun Y, Dai A, Shi X, Wu D, Li F, Hu H, Yang S (2011) Targeted dual-contrast T1- and T2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles. Biomaterials 32:4584
J-s C, Lee J-H, Shin T-H, Song H-T, Kim EY, Cheon J (2010) Self-confirming “AND” logic nanoparticles for fault-free MRI. J Amer Chem Soc 132:11015
Chambon C, Clement O, Leblanche A, Schoumanclaeys E, Frija G (1993) Superparamagnetic iron oxides as positive MR contrast agents: in vitro and in vivo evidence. J Magn Reson Imaging 11(4):509
Taboada E, Rodriguez E, Roig A, Oro J, Roch A, Muller RN (2007) Relaxometric and magnetic characterization of ultrasmall iron oxide nanoparticles with high magnetization. Evaluation as potential T1 magnetic resonance imaging contrast agents for molecular imaging. Langmuir 23(8):4583
Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R (1994) Biodegradable long-circulating polymeric nanospheres. Science 263:1600
Seo WS, Lee JH, Sun X, Suzuki Y, Mann D, Liu Z, Terashima M, Yang PC, McConnell MV, Nishimura DG, Dai H (2006) FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents. Nat Mater 5:971
Huang J, Zhong X, Wang L, Yang L, Mao H (2012) Improving the magnetic resonance imaging contrast and detection methods with engineered magnetic nanoparticles. Theranostics 2(1):86
Jang JT, Nah H, Lee JH, Moon SH, Kim MG, Cheon J (2009) Critical enhancements of MRI contrast and hyperthermic effects by dopant-controlled magnetic nanoparticles. Angew Chem Int Ed 48:1234
Jun YW, Huh YM, Choi JS, Lee JH, Song HT, Kim S, Yoon S, Kim KS, Shin JS, Suh JS, Cheon J (2005) Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J Am Chem Soc 127:5732
Ai H, Flask C, Weinberg B, Shuai X, Pagel MD, Farrell D, Duerk J, Gao JM (2005) Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes. Adv Mater 17:1949
Berret J-F, Schonbeck N, Gazeau F, El Kharrat D, Sandre O, Vacher A, Airiau M (2006) Controlled clustering of superparamagnetic nanoparticles using block copolymers: design of new contrast agents for magnetic resonance imaging. J Am Chem Soc 128:1755
Na HB, Lee JH, An K, Park YI, Park M, Lee IS, Nam D-H, Kim ST, Kim S-H, Kim S-W, Lim K-H, Kim K-S, Kim S-O, Hyeon T (2007) Development of a T1 contrast agent for magnetic resonance imaging using MnO nanoparticles. Angew Chem Int Ed 46(28):5397
Shin J, Anisur RM, Ko MK, Im GH, Lee JH, Lee IS (2009) Hollow manganese oxide nanoparticles as multifunctional agents for magnetic resonance imaging and drug delivery. Angew Chem Int Ed 48:321
Duan H, Kuang M, Wang X, Wang YA, Mao H, Nie S (2008) Reexamining the effects of particle size and surface chemistry on the magnetic properties of iron oxide nanocrystals: new insights into spin disorder and proton relaxivity. J Phys Chem C 112:8127
Tong S, Hou S, Zheng Z, Zhou J, Bao G (2010) Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity. Nano Lett 10:4607
Koenig SH, Kellar KE (1995) Theory of 1/T1 and 1/T2 NMRD profiles of solutions of magnetic nanoparticles. Magn Reson Med 34:227
Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca E, Basilion JP (2000) In vivo magnetic resonance imaging of transgene expression. Nat Med 6:351
Jun YW, Lee JH, Cheon J (2008) Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. Angew Chem Int Ed 47:5122
Bulte JWM, Douglas T, Witwer B, Zhang SC, Strable E, Lewis BK, Zywicke H, Miller B, van Gelderen P, Moskowitz BM, Duncan ID, Frank JA (2001) Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 19:1141
de Vries IJM, Lesterhuis WJ, Barentsz JO, Verdijk P, van Krieken JH, Boerman OC, Oyen WJG, Bonenkamp JJ, Boezeman JB, Adema GJ, Bulte JWM, Scheenen TWJ, Punt CJA, Heerschap A, Figdor CG (2005) Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol 23:1407
Zhao M, Beauregard DA, Loizou L, Davletov B, Brindle KM (2001) Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat Med 7:1241
Schellenberger EA, Sosnovik D, Weissleder R, Josephson L (2004) Magneto/optical Annexin V, a multimodal protein. Bioconjugate Chem 15:1062
Sosnovik D, Weissleder R (2007) Emerging concepts in molecular MRI. Curr Opin Biotechnol 18:4
Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R (2003) Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 348:2491
Kapp DS, Hahn GM, Carlson RW (2000) Principles of hyperthermia. Decker, Ontario
Gü S (2004) Nanoparticles: from theory to application. Wiley-VCH, Weinheim
Mornet S, Vasseur S, Grasset F, Duguet E (2004) Magnetic nanoparticle design for medical diagnosis and therapy. J Mater Chem 14:2161
Andra W, Nowak H (1998) Magnetism in medicine: a handbook. Wiley-VCH, Berlin
Hergt R, Andra W, d’Ambly CG, Hilger I, Kaiser WA, Richter U, Schmidt HG (1998) Physical limits of hyperthermia using magnetite fine particles. IEEE Trans Magn 34:3745
Fortin JP, Wilhelm C, Servais J, Ménager C, Bacri JC, Gazeau F (2007) Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. J Am Chem Soc 129:2628
Eggeman AS, Majetich SA, Farrell D, Pankhurst QA (2007) Size and concentration effects on high frequency hysteresis of iron oxide nanoparticles. IEEE Trans Magn 43:2451
magforce®. www.magforce.com
Hergt R, Dutz S, Röder M (2008) Effects of size distribution on hysteresis losses of magnetic nanoparticles for hyperthermia. J Phys: Condens Matter 20:385214
Rosensweig RE (2002) Heating magnetic fluid with alternating magnetic field. J Magn Magn Mater 252:370
Hergt R, Dutz S, Ziesberger M (2010) Validity limits of the Néel relaxation model of magnetic nanoparticles for hyperthermia. Nanotecnology 21:015706
Carrey J, Mehdaoui B, Respaud M (2011) Simple models for dynamic hysteresis loop calculations of magnetic single-domain nanoparticles: Application to magnetic hyperthermia optimization. J Appl Phys 109:083921
Tefferi A (2003) A contemporary approach to the diagnosis and management of polycythemia vera. Curr Hematol Rep 2(3):237
Kuimova MK (2012) Mapping viscosity in cells using molecular rotors. Phys Chem Chem Phys 14(37):12671
Wang X, Tang J, Shi L (2010) Induction heating of magnetic fluids for hyperthermia treatment. IEEE Trans Mag 46:1043
Zhang LY, Gu HC, Wang XM (2007) Magnetite ferrofluid with high specific absorption rate for application in hyperthermia. J Mag Mag Mater 311:228
Wang X, Gu H, Yang Z (2005) The heating effect of magnetic fluids in an alternating magnetic field. J Magn Magn Mater 293:334
Fortin JP, Gazeau F, Wilhelm C (2008) Intracellular heating of living cells through Néel relaxation of magnetic nanoparticles. Biophys Lett 37:223
Ma M, Wu Y, Zhou J, Sun Y, Zhang Y, Gu N (2004) Size dependence of specific power absorption of Fe3O4 particles in AC magnetic field. J Magn Magn Mater 268:33
de la Presa P, Luengo Y, Multinger M, Costo R, Morales MP, Rivero G, Hernando A (2012) Study of heating efficiency as a function of concentration, size, and applied field in γ-Fe2O3 nanoparticles. J Phys Chem 116:25602
Motoyama J, Hakata T, Kato R, Yamashita N, Morino T, Kobayashi T, Honda H (2008) Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles. Biomagnetic Res Techn 6(4):1
Cótica LF, Santos IA, Girotto EM, Ferri EV, Coelho AA (2010) Surface spin disorder effects in magnetite and poly(thiophene)-coated magnetite nanoparticles. J Appl Phys 108:064325
Guardia P, Batlle-Brugal B, Roca AG, Iglesias O, Morales MP, Serna CJ, Labarta A, Batlle X (2007) Surfactant effects in magnetite nanoparticles of controlled size. J Magn Magn Mater 316:e756
Dionigi C, Piñeiro Y, Riminucci A, Bañobre-López M, Rivas J, Dediu V (2013) Regulating the thermal response of PNIPAM hydrogels by controlling the adsorption of magnetite nanoparticles. Appl Phys A (in press)
Regmi R, Bhattarai SR, Sudakar C, Wani CS, Cunningham R, Vaishnava PP, Naik R, Oupicky D, Lawes G (2010) Hyperthermia controlled rapid drug release from thermosensitive magnetic microgels. J Mater Chem 20:6158
Urtizberea A, Natividad E, Arizaga A, Castro M, Mediano A (2010) Specific absorption rates and magnetic properties of ferrofluids with interaction effects at low concentrations. J Phys Chem C 114:4916
Linh PH, Thach PV, Tuan NA, Thuan NC, Mahn DH, Phuc NX, Hong LV (2009) Magnetic fluid based on Fe3O4 nanoparticles: preparation and hyperthermia application. J Phys: Conf Ser 187:012069
Martinez-Boubeta C, Simeonidis K, Serantes D, Conde-Leborán I, Kazakis I, Stefanou G, Peña L, Galceran R, Balcells L, Monty C, Baldomir D, Mitrakas M, Angelakeris M (2012) Adjustable hyperthermia response of self-assembled ferromagnetic Fe-MgO core–shell nanoparticles by tuning dipole–dipole interactions. Adv Funct Mater 22(17):1
Calvo-Fuentes J, Rivas J, López-Quintela MA (2012) Synthesis of subnanometric metal nanoparticles. In: Bhushan B (ed) Encyclopedia of nanotechnology. Springer Verlag, Heidelberg, Germany, p 2639
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The authors would like to thank Prof. Carlos Vázquez-Vázquez for the critical reading of this manuscript. Undoubtedly, his comments have contributed to a significant quality improvement of this chapter.
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Bañobre-López, M., Piñeiro, Y., López-Quintela, M.A., Rivas, J. (2014). Magnetic Nanoparticles for Biomedical Applications. In: Bhushan, B., Luo, D., Schricker, S., Sigmund, W., Zauscher, S. (eds) Handbook of Nanomaterials Properties. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31107-9_29
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