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Stabilization and Characterization of Iron Oxide Superparamagnetic Core-Shell Nanoparticles for Biomedical Applications

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Handbook of Nanomaterials Properties

Abstract

Superparamagnetic iron oxide nanoparticles (NPs) are used in a rapidly expanding number of research and practical applications in the biomedical field. These applications require good NP stability at physiological conditions, close control over NP size, and controlled surface presentation of functionalities. Such performance can only be reached by densely grafted, polymer, sterically stabilized core-shell nanoparticles, where the polymer shell interaction with the environment determines the colloidal properties of the nanoparticle. A critical evaluation of different strategies to stabilize and functionalize superparamagnetic core-shell iron oxide nanoparticles in terms of physicochemical properties is necessary to ascertain that the desired performance can be reached in the final application.

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Authors and Affiliations

  1. Department of Nanobiotechnology, Institute for Biologically Inspired Materials, University of Natural Resources and Life Sciences Vienna, Vienna, Austria

    Erik Reimhult

  2. Department of Physics, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA

    Esther Amstad

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  1. Erik Reimhult
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  2. Esther Amstad
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Correspondence to Erik Reimhult .

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Editors and Affiliations

  1. Nanoprobe Laboratory for Bio- & Nanotechnology and Biomimetics, Ohio State University, Columbus, Ohio, USA

    Bharat Bhushan

  2. Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USA

    Dan Luo

  3. Division of Restorative, Prosthetic and Primary Care, The Ohio State University, College of Dentistry, Columbus, Ohio, USA

    Scott R. Schricker

  4. Department of Materials Science and Engineering, University of Florida, Gainesville, Florida, USA

    Wolfgang Sigmund

  5. Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA

    Stefan Zauscher

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Reimhult, E., Amstad, E. (2014). Stabilization and Characterization of Iron Oxide Superparamagnetic Core-Shell Nanoparticles for Biomedical Applications. In: Bhushan, B., Luo, D., Schricker, S., Sigmund, W., Zauscher, S. (eds) Handbook of Nanomaterials Properties. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31107-9_19

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