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Population Genetics

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The Prokaryotes

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Abstract

The rapid development of sequencing technology over recent years has both transformed molecular epidemiological surveillance and provided unprecedented detail concerning the molecular evolutionary processes occurring over very short time scales in bacterial pathogens. Here we review recent developments, with an emphasis on the application of next-generation sequencing platforms to understand the spread and diversification of methicillin-resistant Staphylococcus aureus (MRSA). We discuss how these datasets may provide information on transmission dynamics at different epidemiological scales, but also consider methods to gauge the strength of purifying selection acting on populations and subpopulations, and how this is likely to intersect with the ecology or epidemiology of different species or clones. We also discuss how these datasets are shedding light on other evolutionary properties of bacteria, such as genomic base composition, recombination, and mutation rate.

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Acknowledgments

SCR is funded by the TROCAR consortium (FP7-HEALTH #223031). We are grateful to colleagues present at the first international PERMAFROST meeting, Bormio, Italy, on March 5–8 2010, and for their fruitful discussions.

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Authors and Affiliations

  1. Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK

    Santiago Castillo-Ramírez & Dr. Edward J. Feil

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  1. Santiago Castillo-Ramírez
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  2. Dr. Edward J. Feil
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Correspondence to Edward J. Feil .

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Editors and Affiliations

  1. Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel

    Eugene Rosenberg

  2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    Edward F. DeLong

  3. Department of Microbiology and Immunology, Harvard Medical School, Boston, MA, USA

    Stephen Lory

  4. Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany

    Erko Stackebrandt

  5. Laboratory of Microbiology, Institute of Biology, Center for Health Sciences, Federal University of Rio de Janeiro (UFRJ), Ilha do Fundão, Rio de Janeiro, Brazil

    Fabiano Thompson

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Castillo-Ramírez, S., Feil, E.J. (2013). Population Genetics. In: Rosenberg, E., DeLong, E.F., Lory, S., Stackebrandt, E., Thompson, F. (eds) The Prokaryotes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30194-0_83

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