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Therapeutic Insight Into Reactive Oxygen Species Regulation of Neovascularization

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Systems Biology of Free Radicals and Antioxidants

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Abstract

Angiogenesis, characterized by the development of new blood vessels from preexisting vasculature, is an important aspect of both healthy and disease states. Recently, reactive oxygen species (ROS) have garnered increased attention as mediators of cell signaling, extending its role beyond simple oxidative stress and damage. Studies have gradually begun to determine links between ROS and cell survival, cell signaling, and the pathophysiology of diseases, both in vitro and in vivo. There are multiple players involved in ROS regulation, with NADPH oxidase, the mitochondria, and superoxide dismutase being some of the most studied regulators. These regulators of ROS have been linked to downstream signaling of a variety of signaling factors, such as vascular endothelial growth factor (VEGF). In addition, ROS have been identified to play a critical role in cells essential for the development of new vasculature, including endothelial, immune, and progenitor cells. Furthermore, a number of studies are pointing at ROS as being an important regulator of pathological angiogenesis in various diseases such as diabetes and tumorigenesis. Herein, we review the literature with regard to ROS regulation of angiogenesis, which has gained more interest in recent years, as we begin to comprehend ROS not as a group of cytotoxic waste products but as critical regulators of angiogenic homeostasis.

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Authors and Affiliations

  1. Institute for Heart and Lung Health at St. Paul’s Hospital, The James Hogg Research Centre, and Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 1081 Burrard St., Rm 166, Vancouver, BC, Canada

    Andy E. Trane & Pascal N. Bernatchez

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  1. Andy E. Trane
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  2. Pascal N. Bernatchez
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Correspondence to Pascal N. Bernatchez .

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Trane, A.E., Bernatchez, P.N. (2014). Therapeutic Insight Into Reactive Oxygen Species Regulation of Neovascularization. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_60

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