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Free Radicals and Embryo Development

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Systems Biology of Free Radicals and Antioxidants

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Abstract

The development of the embryo depends on a sequence of tightly regulated events. A multitude of regulatory networks facilitate spatial and temporal control of embryo development and ascertain that the embryo proceeds safely through the developmental stages. During this process, the embryo encounters changing environmental conditions that may affect the developmental outcome. Oxygen is essential for embryogenesis but also poses a potential hazard via the formation of reactive oxygen and reactive nitrogen species (ROS/RNS). ROS are capable of modifying and deactivating macromolecules (proteins, nucleic acids, lipids) and thereby are able to disturb normal development. On the other hand, ROS/RNS are vital signaling molecules within cells. Thus, precise control of ROS/RNS generation and their clearance are necessary and dysregulations disturb embryo development, which may lead to developmental abnormalities or even embryonic death. In order to cope with ROS/RNA, the embryo features intriguing mechanisms to sense oxygen derivatives and translate this information into adaptive events. This chapter summarizes our current knowledge in the field of free radicals during mammalian embryo development.

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Authors and Affiliations

  1. Institute of Biochemistry, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Christoph Ufer & Hartmut Kuehn

  2. Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong

    Tang Ling Yin & Chi Chiu Wang

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  1. Christoph Ufer
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  2. Hartmut Kuehn
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  3. Tang Ling Yin
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  4. Chi Chiu Wang
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Correspondence to Christoph Ufer .

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Ufer, C., Kuehn, H., Yin, T.L., Wang, C.C. (2014). Free Radicals and Embryo Development. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_34

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