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Oxidative Stress and Alzheimer’s Disease

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Systems Biology of Free Radicals and Antioxidants

Abstract

Senile plaques, neurofibrillary tangles, and neuronal loss are three neuropathological hallmarks of Alzheimer’s disease (AD). Advanced understanding of the link between oxidative stress and the characteristics of AD neuropathology has placed oxidative stress in the center of AD pathogenesis. A large body of evidence indicates that oxidative stress potentiates AD neuropathology and disease progression, which promotes the use of antioxidants as treatments for AD. Indeed, experimental evidence suggests that antioxidants are promising drugs for AD. However, human clinical trials of antioxidant drugs result in inconsistent findings and limited success. Although the correlation between oxidative stress and AD is well established, the antioxidant as a treatment for AD is still an open question requiring further investigations.

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Abbreviations

Alzheimer’s disease:

AD

Amyloid-β precursor protein:

APP

Amyloid-β protein:

Aβ

Beta-site APP-cleaving enzyme 1:

BACE1

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Acknowledgments

This work was supported by Canadian Institutes of Health Research (CIHR) Operating grant TAD-117948 (W.S.). W.S. is the holder of the Tier 1 Canada Research Chair in Alzheimer’s Disease.

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The authors declare no conflict of interest.

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    Authors and Affiliations

    1. Townsend Family Laboratories, Department of Psychiatry and Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada

      Yili Wu, Qin Xu & Weihong Song

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    1. Yili Wu
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    2. Qin Xu
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    3. Weihong Song
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    Correspondence to Weihong Song .

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    Editors and Affiliations

    1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

      Ismail Laher

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    Wu, Y., Xu, Q., Song, W. (2014). Oxidative Stress and Alzheimer’s Disease. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_197

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