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Oxidative Stress and Chronic Renal Disease – Clinical Aspects

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Systems Biology of Free Radicals and Antioxidants

Abstract

Patients with chronic kidney disease (CKD) experience accelerated atherosclerosis, leading to excessive cardiovascular death; oxidative stress may be a pathogenic mediator of this process. Oxidative stress is prevalent in CKD patients. Accordingly, increased oxidative stress and/or reduced antioxidant defenses have been associated with endothelial dysfunction and increased carotid intima-media thickness in CKD patients. Other studies have found a possible association between oxidative stress and a faster progression rate of kidney damage. Oxidative stress also influences the response to erythropoiesis-stimulating agents. Among possible therapeutic approaches, the use of vitamin E seems the most promising. Why antioxidant therapy is not as effective as it would be expected from the role of oxidative stress in pathogenic mechanisms remains an open question.

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Authors and Affiliations

  1. Department of Nephrology, Dialysis, and Renal Transplant, A Manzoni Hospital, Via dell’Eremo 9, 23900, Lecco, Italy

    Lucia Del Vecchio, Andrea Cavalli & Francesco Locatelli

  2. Department of Pharmaceutical Sciences, P. Pratesi – Università degli Studi di Milano, Milan, Italy

    Marina Carini

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  1. Lucia Del Vecchio
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  2. Marina Carini
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  3. Andrea Cavalli
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  4. Francesco Locatelli
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Correspondence to Francesco Locatelli .

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Del Vecchio, L., Carini, M., Cavalli, A., Locatelli, F. (2014). Oxidative Stress and Chronic Renal Disease – Clinical Aspects. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_179

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