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Zusammenfassung

Aphasien sind erworbene Sprachstörungen. Betroffen sind die sprachrelevanten Areale (»Sprachzentrum«), die bei über 90 % der Menschen an die seitliche Hirnfurche der linken Großhirnrinde angrenzen (perisylvische Region). Aphasien betreffen alle Modalitäten (Sprechen, Verstehen, Lesen und Schreiben) und alle Anteile des Sprachwissens (Lexikon, Syntax, Morphologie und Phonologie), wenn auch in unterschiedlicher Ausprägung. Es finden sich charakteristische Kombinationen von Symptomen, die als klinische Aphasiesyndrome beschrieben werden. FMRT-Studien bei Aphasikern untersuchen meist normalsprachliche Funktionen, zu neuronalen Korrelaten aphasischer Symptome liegt bisher nur wenig vor.

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Literatur

  • Abo M, Senoo A, Watanabe S et al. (2004) Language-related brain function during word repetition in post-stroke aphasics. NeuroReport 15: 1891–1894

    Article  PubMed  Google Scholar 

  • Blomert L, Kean ML, Koster C, Schokker J (1994) Amsterdam-Nijmegen Everyday Language Test: construction, reliability and validity. Aphasiology 8: 381–407

    Article  Google Scholar 

  • Bonakdarpour B, Parrish TB, Thompson CK (2007) Haemodynamic response function in patients with stroke-induced aphasia: Implications for fMRI data analysis. Neuroimage 36: 322–331

    Article  PubMed  CAS  Google Scholar 

  • Cao Y, Vikingstad BS, George KP, Johnson AF, Welch KM (1999) Cortical language activation in stroke patients recovering from aphasia. Stroke 30: 2331–2340

    Article  PubMed  CAS  Google Scholar 

  • Cherney LR, Small SL (2006) Task-dependent changes in brain activation following therapy for nonfluent aphasia: Discussion of two individual cases. J Intern Neuropsychol Soc 12: 828–842

    Google Scholar 

  • Code C (2011) Nonfluent aphasia and the evolution of proto-language. J Neuroling 24: 136–144

    Article  Google Scholar 

  • Crinion J, Price CJ (2005) Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke. Brain 128: 2858–2871

    Article  PubMed  Google Scholar 

  • Crosson B, McGregor K, Gopinath KS et al. (2007) Functional MRI of language in aphasia: A review of the literature and the methodological challenges. Neuropsychol Rev 17: 157–177

    Article  PubMed  Google Scholar 

  • Crosson B, Moore AB, McGregor KM et al. (2009) Regional changes in word-production laterality after a naming treatment designed to produce a rightward shift in frontal activity. Brain Lang 111: 73–85

    Article  PubMed  Google Scholar 

  • Fernandez B, Cardebat D, Démonet JF et al. (2004) Functional MRI follow-up study of language processes in healthy subjects and during recovery in a case of aphasia. Stroke 35: 2171–2176

    Article  PubMed  Google Scholar 

  • Flöel A, Ellger T, Breitenstein C, Knecht S (2003) Language perception activates the hand motor cortex: implications for motor theories of speech perception. Eur J Neurosci 18: 704–708

    Article  PubMed  Google Scholar 

  • Fridriksson J, Morrow-Odom L, Moser D, Fridriksson A, Baylis G (2006) Neural recruitment associated with anomia treatment in aphasia. Neuroimage 32: 1403–1412

    Article  PubMed  Google Scholar 

  • Fridriksson J, Moser D, Bonilha L et al. (2007) Neural correlates of phonological and semantic-based anomia treatment in aphasia. Neuropsychologia 45: 1812–1822

    Article  PubMed  Google Scholar 

  • Fridriksson J, Baker JM, Moser D (2009) Cortical mapping of naming errors in aphasia. Hum Brain Mapp 30: 2487–2498

    Article  PubMed  Google Scholar 

  • Gazzaniga MS (2005) Forty-five years of split-brain research and still going strong. Nat Rev Neurosci 6: 653–659

    Article  PubMed  CAS  Google Scholar 

  • Gold BT, Kertesz A (2000) Preserved visual lexicosemantics in global aphasia: a right-hemisphere contribution? Brain Lang 73: 456–465

    Article  PubMed  CAS  Google Scholar 

  • Grande M, Weis S, Willmes K, Huber W (2003) Recovery of word form processing after left inferior parietal lesion: a single case fMRI study. Brain Lang 87: 124–125

    Article  Google Scholar 

  • Hadar U, Wenkert-Olenik D, Krauss R, Soroker N (1998) Gesture and the processing of speech: neuropsychological evidence. Brain Lang 62: 107–126

    Article  PubMed  CAS  Google Scholar 

  • Hartje W (2006) Funktionelle Asymmetrie der Großhirnhemisphären. In: Hartje W, Poeck K (Hrsg) Klinische Neuropsychologie. Thieme, Stuttgart, S 67–92

    Google Scholar 

  • Heim S, Opitz B, Friederici AD (2003) Distributed cortical networks for syntax processing: Broca’s area as the common denominator. Brain Lang 85: 402–408

    Article  PubMed  Google Scholar 

  • Heiss WD, Thiel A (2006) A proposed regional hierarchy in recovery of post-stroke aphasia. Brain Lang 98: 118–123

    Article  PubMed  Google Scholar 

  • Heiss WD, Karbe H, Weber-Luxenburger G et al. (1997) Speech-induced cerebral metabolic activation reflects recovery from aphasia. J Neurol Sci 145: 213–217

    Article  PubMed  CAS  Google Scholar 

  • Heiss WD, Kessler J, Thiel A, Ghaemi M, Karbe H (1999) Differential capacity of left and right hemispheric areas for compensation of poststroke aphasia. Ann Neurol 45: 430–438

    Article  PubMed  CAS  Google Scholar 

  • Hillis AE, Heidler J (2002) Mechanisms of early aphasia recovery. Aphasiology 16: 885–895

    Article  Google Scholar 

  • Huber W, Ziegler W (2000) Störungen von Sprache und Sprechen. In: Sturm W, Herrmann M, Wallesch CW (Hrsg) Lehrbuch der klinischen Neuropsychologie. Grundlagen, Methoden, Diagnostik, Therapie. Swets & Zeitlinger, Lisse, S 462–511

    Google Scholar 

  • Huber W, Poeck K, Weniger D, Willmes K (1983) Aachener Aphasie Test (AAT). Handanweisung. Hogrefe, Göttingen

    Google Scholar 

  • Huber W, Grande M, Springer L (2005) Aachener Sprachanalyse (ASPA). Delta Systems, Aachen

    Google Scholar 

  • Huber W, Poeck K, Weniger D (2006) Aphasie. In: Hartje W, Poeck K (Hrsg) Klinische Neuropsychologie. Thieme, Stuttgart, S 93–173

    Google Scholar 

  • Indefrey P, Hagoort P, Herzog H, Seitz RJ, Brown CM (2001) Syntactic processing in left prefrontal cortex is independent of lexical meaning. NeuroImage 14: 546–555

    Article  PubMed  CAS  Google Scholar 

  • Jackson H (1879) On affections of speech from disease of brain. Brain 2: 203–222

    Article  Google Scholar 

  • Karbe H, Thiel A, Weber-Luxenburger G, Herholz KJK, Heiss WD (1998) Brain plasticity in poststroke aphasia: What is the contribution of the right hemisphere? Brain Lang 64: 215–230

    Article  PubMed  CAS  Google Scholar 

  • Kotz SA, Schwartze M, Schmidt-Kassow M (2009) Non-motor basal ganglia functions: a review and proposal for a model of sensory predictability in auditory language perception. Cortex 45: 982–990

    Article  PubMed  Google Scholar 

  • Lomas J, Pickard L, Bester S, Elbard H, Finlayson A, Zoghaib C (1989) The communicative effectiveness index: development and psychometric evaluation of a functional communication measure for adult aphasia. J Speech Hear Disord 54: 113–124

    PubMed  CAS  Google Scholar 

  • Longoni F, Grande M, Hendrich V, Kastrau F, Huber W (2004) An fMRI study on conceptual, grammatical and morpho-phonological processing. Brain Cogn 57: 131–134

    Article  Google Scholar 

  • Marshall JF (1984) Brain function: neural adaptations and recovery from injury. Ann Rev Psych 35: 277–308

    Article  CAS  Google Scholar 

  • Meffert E, Tillmanns E, Heim S, Jung S, Huber W, Grande M (2011) Taboo: a novel paradigm to elicit aphasia-like trouble-indicating behaviour in normally speaking individuals. J Psycholinguist Res 40: 307–326

    Article  PubMed  Google Scholar 

  • Meinzer M, Flaisch T, Obleser J et al. (2006) Brain regions essential for improved lexical access in an aged aphasic patient: A case report. BMC Neurology 6: 28

    Article  PubMed  Google Scholar 

  • Meinzer M, Flaisch T, Breitenstein C, Wienbruch C, Elbert T, Rockstroh B (2008) Functional re-recruitment of dysfunctional brain areas predicts language recovery in chronic aphasia. Neuroimage 39: 2038–2046

    Article  PubMed  Google Scholar 

  • Meister IG, Boroojerdi B, Folty H, Sparing R, Huber W, Töpper R (2003) Motor kortex hand area and speech: implications for the development of language. Neuropsychologia 41: 401–406

    Article  PubMed  Google Scholar 

  • Naeser MA, Martin PI, Baker EH et al. (2004) Overt prepositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI method. NeuroImage 22: 29–41

    Article  PubMed  Google Scholar 

  • Naeser MA, Martin PI, Nicholas M et al. (2005) Improved picture naming in chronic aphasia after TMS to part of right Broca’s area: An open-protocol study. Brain Lang 93: 95–105

    Article  PubMed  Google Scholar 

  • Perani D, Cappa SF, Tettamanti M et al. (2003) A fMRI study of word retrieval in aphasia. Brain Lang 85: 357-368

    Article  PubMed  CAS  Google Scholar 

  • Poeck K (1983) What do we mean by »aphasic syndromes«? A neurologist’s view. Brain Lang 20: 79–89

    Article  PubMed  CAS  Google Scholar 

  • Price CJ, Warburton EA, Moore CJ, Frackowiak RS, Friston KJ (2001) Dynamic diaschisis: anatomically remote and context-sensitive human brain lesions. J Cognit Neurosci 13: 419–429

    Article  CAS  Google Scholar 

  • Richter M, Miltner WH, Straube T (2008) Association between therapy outcome and righthemispheric activation in chronic aphasia. Brain 131: 1391–1401

    Article  PubMed  Google Scholar 

  • Riecker A, Wildgruber D, Grodd W, Ackermann H (2002) Reorganization of speech production at the motor kortex and cerebellum following capsular infarction: a follow-up functional magnetic resonance imaging study. Neurocase 8: 417–423

    Article  PubMed  Google Scholar 

  • Rosen HJ, Petersen SE, Linenweber MR, Snyder AZ, White DA, Chapman L, Dromerick AW, Fiez JA, Corbetta MD (2000) Neural correlates of recovery from aphasia after damage to left inferior frontal cortex. Neurology 55: 1883–1894

    Article  PubMed  CAS  Google Scholar 

  • Saur D, Lange R, Baumgaertner A, Schraknepper V et al. (2006) Dynamics of language reorganisation after stroke. Brain 129: 1371–1384

    Article  PubMed  Google Scholar 

  • Saur D, Ronneberger O, Kümmerer D, Mader I, Weiller C, Klöppel S (2010) Early functional magnetic resonance imaging activations predict language outcome after stroke. Brain 133: 1252–1264

    Article  PubMed  Google Scholar 

  • Small SL, Flores DK, Noll DC (1998) Different neural circuits subserve reading before and after therapy for acquired dyslexia. Brain Lang 62: 298–308

    CAS  Google Scholar 

  • Specht K, Herzog H, Heßelmann V et al. (1998) Transkortikale Aphasie als Kompensationssyndrom der rechten Hemisphäre? In: Hielscher M, Clarenbach P, Elsner S, Huber W, Simons B (Hrsg) Beeinträchtigungen des Mediums Sprache. Stauffenburg, Tübingen, S 37–56

    Google Scholar 

  • Springer L, Huber W, Schlenck KJ, Schlenck C (2000) Agrammatism: Deficit or compensation? Consequences for aphasia therapy. Neuropsychol Rehabil 10: 279–309

    Article  Google Scholar 

  • Thompson CK, Bonakdarpour B, Fix SF (2010) Neural mechanisms of verb argument structure processing in agrammatic aphasic and healthy age-matched listeners. J Cognit Neurosci 22: 1993–2011

    Article  Google Scholar 

  • Thulborn KR, Carpenter PA, Just MA (1999) Plasticity of language-related brain function during recovery from stroke. Stroke 30: 749–754

    Article  PubMed  CAS  Google Scholar 

  • Tillmanns E, Meffert E, Heim S et al. (2011) Neuronale Korrelate lexikalischen Suchverhaltens in der aphasischen Spontansprache: Ein Einzelfall. Sprache – Stimme – Gehör. Online-Publikation. DOI: http://dx.doi.org/ 10.1055/s-0031-1271760

    Google Scholar 

  • Vitali P, Abutalebi J, Tettamanti M et al. (2007) Training induced brain remapping in chronic aphasia: A pilot study. Neurorehabilitation & Neural Repair 21: 152–160

    Article  Google Scholar 

  • Weiller C, Isensee C, Rijntjes M et al. (1995) Recovery from Wernicke’s aphasia: a positron emission tomographic study. Ann Neurol 37: 723–732

    Article  PubMed  CAS  Google Scholar 

  • Weis S, Grande M, Pollrich S, Willmes K, Huber W (2001) Processing of homonyms: a functional MRI study on the separation of word forms from concepts. Kortex 37: 745–749

    CAS  Google Scholar 

  • Westerhausen R, Hugdahl K (2008) The corpus callosum in dichotic listening studies on hemispheric asymmetry: a review of clinical and experimental evidence. Neurosci Biobehav Rev 32: 44–54

    Article  Google Scholar 

  • Wierenga CE, Maher LM, Moore AB et al. (2006) Neural substrates of syntactic mapping treatment: An fMRI study of two cases. J Int Neuropsychol Soc 12: 132–146

    Article  PubMed  Google Scholar 

  • Willmes K, Poeck K (1993) To what extent can aphasic syndromes be localized? Brain 116: 1527–1540

    Article  PubMed  Google Scholar 

  • Zahn R, Huber W, Drews E et al. (2002) Recovery of semantic word processing in transcortical sensory aphasia: a functional magnetic resonance imaging study. Neurocase 8: 376–386

    Article  PubMed  Google Scholar 

  • Zahn R, Drews E, Specht K et al. (2004) Recovery of semantic word processing in global aphasia: a functional MRI study. Cogn Brain Res 18: 322–336

    Article  Google Scholar 

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Grande, M., Huber, W. (2013). Aphasie. In: Schneider, F., Fink, G.R. (eds) Funktionelle MRT in Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29800-4_35

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  • DOI: https://doi.org/10.1007/978-3-642-29800-4_35

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