Abstract
The development of multiple myeloma (MM) is a multistep process including sequential series of genetic abnormalities. Failure to obtain informative metaphases from conventional cytogenetic techniques might be overcome by using molecular cytogenetic methods, which utilize DNA from interphase nuclei, thus permitting the evaluation of chromosomal regions in non-dividing cells. The advent of molecular biology methods, such as fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH) or gene expression profiling (GEP) has provided new insights into the biology of MM. These methods may help to explain clinical heterogeneity of MM and to differentiate between the disease subtypes related to good and bad prognosis.
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Dmoszyńska, A., Chocholska, S. (2012). Molecular Biology Methods in the Diagnosis of Multiple Myeloma. In: Witt, M., Dawidowska, M., Szczepanski, T. (eds) Molecular Aspects of Hematologic Malignancies. Principles and Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29467-9_27
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DOI: https://doi.org/10.1007/978-3-642-29467-9_27
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