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Translational Research Methods: The Value of Animal Models in Renal Research

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Pediatric Nephrology

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Abstract

The use of animal models has been an essential aspect of nearly all areas of nephrological research since its earliest days. Research on kidney formation and malformation, physiology and pathophysiology, immunological injury, and tolerance or transplant rejection all depend on the use of animal experimentation. This chapter will emphasize genetic approaches that utilize animals, as this area has shown the great progress in the development of novel technologies that have had great impact in all areas of nephrology.

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Authors and Affiliations

  1. Children’s Hospital Boston, Boston, MA, USA

    Jordan Kreidberg

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  1. Jordan Kreidberg
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Correspondence to Jordan Kreidberg .

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Editors and Affiliations

  1. Children's Hospital of Wisconsin Children's Research Institute, Milwaukee, Wisconsin, USA

    Ellis D. Avner

  2. Harvard Medical School Children's Hospital Boston, Boston, Massachusetts, USA

    William E. Harmon

  3. Hôpital Necker Enfants Malades Dept. Néphrologie Pédiatrique, Paris, France

    Patrick Niaudet

  4. Wakayama Medical University Dept. Pediatrics, Wakayama City, Japan

    Norishige Yoshikawa

  5. Department of Nephrology and Urology Division of Nephrology, Children's Hospital Bambino Gesù, IRCCS, Rome, Italy

    Francesco Emma

  6. Division of Nephrology and Hypertension The Heart Institute, University of Cincinnati Cincinnati Children’s Hospital Medical C, Cincinnati, Ohio, USA

    Stuart Goldstein

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Kreidberg, J. (2014). Translational Research Methods: The Value of Animal Models in Renal Research. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27843-3_14-1

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  • DOI: https://doi.org/10.1007/978-3-642-27843-3_14-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27843-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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