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Peritoneal Dialysis

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Pediatric Nephrology

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Abstract

Peritoneal dialysis (PD) is currently the most commonly used kidney replacement therapy (KRT) in children worldwide. In this chapter, the fundamentals of peritoneal water and solute transport are detailed, including a description of peritoneal membrane function and transport characteristics. The types of dialysis fluid and their impact on membrane preservation over time on chronic PD and the basic concepts that impact dialysis modality choice are presented. Factors influencing timing of dialysis initiation and choice of catheter and other dialysis equipment, as well as remote patient monitoring options, are reviewed. Once PD is initiated, the dose of dialysis delivered should be measured, typically by measuring urea clearance relative to solute distribution volume (Kt/V). The prescription should be tailored based on the patient’s peritoneal membrane characteristics as measured through the peritoneal equilibrium test (PET) and considering the intraperitoneal pressure. Determination of the adequacy of the dialysis procedure should also consider nutritional status, growth, and the general well-being of the patient, in addition to the correction of the metabolic derangements of chronic kidney failure. The PD procedure must be carefully monitored to avoid common and potentially life-threatening complications. Catheter exit site infection and peritonitis are among the most important complications that require ongoing monitoring, and this chapter reviews guidelines for preventing and treating these complications. Common catheter and dialysis procedure-related complications are discussed; patient outcome on chronic PD and promising perspectives are presented.

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References

  1. Alexander SR, Salusky IB, Warady BA, Watkins SL. Peritoneal dialysis workshop: pediatrics recommendations. Perit Dial Int. 1997;17(Suppl 3):S25–7.

    Article  PubMed  Google Scholar 

  2. Andreoli SP, Langefeld CD, Stadler S, Smith P, Sears A, West K. Risks of peritoneal membrane failure in children undergoing long-term peritoneal dialysis. Pediatr Nephrol. 1993;7(5):543–7.

    Article  CAS  PubMed  Google Scholar 

  3. Andreoli SP, Leiser J, Warady BA, Schlichting L, Brewer ED, Watkins SL. Adverse effect of peritonitis on peritoneal membrane function in children on dialysis. Pediatr Nephrol. 1999;13(1):1–6.

    Article  CAS  PubMed  Google Scholar 

  4. Aranda RA, Romão Júnior JE, Kakehashi E, Domingos W, Sabbaga E, Marcondes M, Abensur H. Intraperitoneal pressure and hernias in children on peritoneal dialysis. Pediatr Nephrol. 2000;14(1):22–4.

    Article  CAS  PubMed  Google Scholar 

  5. Balasubramaniam G, Brown EA, Davenport A, Cairns H, Cooper B, Fan SL, Farrington K, Gallagher H, Harnett P, Krausze S, Steddon S. The pan-Thames EPS study: treatment and outcomes of encapsulating peritoneal sclerosis. Nephrol Dial Transplant. 2009;24(10):3209–15.

    Article  PubMed  Google Scholar 

  6. Bargman JM, Thorpe KE, Churchill DN, CPDS Group. Relative contribution of residual renal function and peritoneal clearance to adequacy of dialysis: a reanalysis of the CANUSA study. J Am Soc Nephrol. 2001;12:2158–62.

    Article  PubMed  Google Scholar 

  7. Bartosova M, Schaefer B, Bermejo JL, Tarantino S, Lasitschka F, Macher-Goeppinger S, Sinn P, Warady BA, Zaloszyc A, Parapatics K, Májek P, Bennett KL, Oh J, Aufricht C, Schaefer F, Kratochwill K, Schmitt CP. Complement activation in peritoneal Dialysis-induced Arteriolopathy. J Am Soc Nephrol. 2018;29(1):268–82.

    Article  CAS  PubMed  Google Scholar 

  8. Bartosova M, Schaefer B, Vondrak K, Sallay P, Taylan C, Cerkauskiene R, Dzierzega M, Milosevski-Lomic G, BĂĽscher R, Zaloszyc A, Romero P, Lasitschka F, Warady BA, Schaefer F, Ujszaszi A, Schmitt CP. Peritoneal Dialysis vintage and glucose exposure but not peritonitis episodes drive peritoneal membrane transformation during the first years of PD. Front Physiol. 2019;2(10):356.

    Article  Google Scholar 

  9. Bashi N, Karunanithi M, Fatehi F, Ding H, Walters D. Remote monitoring of patients with heart failure: an overview of systematic reviews. J Med Internet Res. 2017;19(1):e18.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Bender FH. Avoiding harm in peritoneal dialysis patients. Adv Chronic Kidney Dis. 2012;19(3):171–8.

    Article  PubMed  Google Scholar 

  11. Bernardini J, Price V, Figueiredo A. Peritoneal dialysis patient training, 2006. Perit Dial Int. 2006;26(6):625–32.

    Article  PubMed  Google Scholar 

  12. Blake P, Bargman J, Scott Brimble K, Davison S, Hirsch D, McCormick B, Suri R, Taylor P, Zalunardo N, Tonelli M. Clinical practice guidelines and recommendations on peritoneal dialysis adequacy 2011. Perit Dial Int. 2011;31:218–39.

    Article  PubMed  Google Scholar 

  13. Borzych-Dużałka D, Schaefer F, Warady B. Targeting optimal PD management in children: what have we learned from the IPPN registry? Pediatr Nephrol. 2020; https://doi.org/10.1007/s00467-020-04598-0.

  14. Borzych-Duzalka D, Aki TF, Azocar M, White C, Harvey E, Mir S, Adragna M, Serdaroglu E, Sinha R, Samaille C, Vanegas JJ, Kari J, Barbosa L, Bagga A, Galanti M, Yavascan O, Leozappa G, Szczepanska M, Vondrak K, Tse KC, Schaefer F, Warady BA. Peritoneal Dialysis access revision in children: causes, interventions, and outcomes. Clin J Am Soc Nephrol. 2017;12(1):105–12.

    Article  PubMed  Google Scholar 

  15. Brown EA, Blake PG, Boudville N, Davies S, de Arteaga J, Dong J, Finkelstein F, Foo M, Hurst H, Johnson DW, Johnson M, Liew A, Moraes T, Perl J, Shroff R, Teitelbaum I, Wang AY, Warady B. International Society for Peritoneal Dialysis practice recommendations: prescribing high-quality goal-directed peritoneal dialysis. Perit Dial Int. 2020;40(3):244–53.

    Article  PubMed  Google Scholar 

  16. Burkart J. Poor nutritional status and inflammation: metabolic consequences of peritoneal Dialysis. Semin Dial. 2004;17(6):498–504.

    Article  PubMed  Google Scholar 

  17. Canada-USA (CANUSA) Peritoneal Dialysis Study Group. Adequacy of dialysis and nutrition in continuous peritoneal dialysis: association with clinical outcomes. Canada-USA (CANUSA) peritoneal Dialysis study group. J Am Soc Nephrol. 1996;7:198–207.

    Article  Google Scholar 

  18. Carey WA, Martz KL, Warady BA. Outcome of patients initiating chronic peritoneal Dialysis during the first year of life. Pediatrics. 2015;136(3):e615–22.

    Article  PubMed  Google Scholar 

  19. Chagnac A, Herskovitz P, Ori Y, Weinstein T, Hirsh J, Katz M, Gafter U. Effect of increased dialysate volume on peritoneal surface area among peritoneal dialysis patients. J Am Soc Nephrol. 2002;13(10):2554–9. Schaefer B, 2014

    Article  PubMed  Google Scholar 

  20. Chan EYH, Borzych-Duzalka D, Alparslan C, Harvey E, Munarriz RL, Runowski D, Vidal E, Coccia PA, Jankauskiene A, Principi I, Serdaroglu E, Szczepanska M, Tse Y, Vazquez A, Weaver DJ, Schaefer F, Warady BA. Colostomy in children on chronic peritoneal dialysis. Pediatr Nephrol. 2020;35(1):119–26.

    Article  PubMed  Google Scholar 

  21. Chand DH, Bednarz D. Daily remote peritoneal dialysis monitoring: an adjunct to enhance patient care. Perit Dial Int. 2008;28(5):533–7.

    Article  PubMed  Google Scholar 

  22. Chesnaye N, Bonthuis M, Schaefer F, Groothoff JW, Verrina E, Heaf JG, Jankauskiene A, Lukosiene V, Molchanova EA, Mota C, Peco-Antic A, Ratsch IM, Bjerre A, Roussinov DL, Sukalo A, Topaloglu R, Van Hoeck K, Zagozdzon I, Jager KJ, Van Stralen KJ. Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA-EDTA registry. Pediatr Nephrol. 2014;29(12):2403–10.

    Article  PubMed  Google Scholar 

  23. Chesnaye NC, Schaefer F, Groothoff JW, Bonthuis M, Reusz G, Heaf JG, Lewis M, Maurer E, Paripovic D, Zagozdzon I, van Stralen KJ, Jager KJ. Mortality risk in European children with end-stage renal disease on dialysis. Kidney Int. 2016;89(6):1355–62.

    Article  PubMed  Google Scholar 

  24. Chow KM, Szeto CC, Li PK-T. Review articles: management options for hydrothorax complicating peritoneal Dialysis. Semin Dial. 2003;16(5):389–94.

    Article  PubMed  Google Scholar 

  25. Chua AN, Warady BA. Adherence of pediatric patients to automated peritoneal dialysis. Pediatr Nephrol. 2011;26(5):789–93.

    Article  PubMed  Google Scholar 

  26. Dejardin A, Robert A, Goffin E. Intraperitoneal pressure in PD patients: relationship to intraperitoneal volume, body size and PD-related complications. Nephrol Dial Transplant. 2007;22(5):1437–44.

    Article  PubMed  Google Scholar 

  27. Del Peso G, Bajo MA, Costero O, Hevia C, Gil F, Díaz C, Aguilera A, Selgas R. Risk factors for abdominal wall complications in peritoneal dialysis patients. Perit Dial Int. 2003;23(3):249–54.

    Article  PubMed  Google Scholar 

  28. Delarue J, Maingourd C. Acute metabolic effects of dialysis fluids during CAPD. Am J Kidney Dis. 2001;37(1 Suppl 2):S103–7.

    Article  CAS  PubMed  Google Scholar 

  29. Devuyst O, Rippe B. Water transport across the peritoneal membrane. Kidney Int. 2014;85(4):750–8.

    Article  CAS  PubMed  Google Scholar 

  30. Dufek S, Holtta T, Fischbach M, Ariceta G, Jankauskiene A, Cerkauskiene R, Schmitt CP, Schaefer B, Aufricht C, Wright E, Stefanidis CJ, Ekim M, Bakkaloglu S, Klaus G, Zurowska A, Vondrak K, Vande Walle J, Edefonti A. Shroff R; European Paediatric Dialysis working group. Pleuro-peritoneal or pericardio-peritoneal leak in children on chronic peritoneal dialysis-a survey from the European Paediatric Dialysis working group. Pediatr Nephrol. 2015;30(11):2021–7.

    Article  PubMed  Google Scholar 

  31. Edefonti A, Boccola S, Picca M, Paglialonga F, Ardissino G, Marra G, Ghio L, Parisotto MT. Treatment data during pediatric home peritoneal teledialysis. Pediatr Nephrol. 2003;18(6):560–4.

    Article  PubMed  Google Scholar 

  32. Eich G, Bartosova M, Tischer C, Wlodkowski TT, Schaefer B, Pichl S, Kraewer N, Ranchin B, Vondrak K, Liebau MC, Hackert T, Schmitt CP. Bicarbonate buffered peritoneal dialysis fluid upregulates angiopoietin-1 and promotes vessel maturation. PLoS One. 2017;12(12):e0189903.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  33. Ellis EN, Pearson D, Champion B, Wood EG. Outcome of infants on chronic peritoneal dialysis. Adv Perit Dial. 1995;11:266–9.

    CAS  PubMed  Google Scholar 

  34. Elphick EH, Teece L, Chess JA, Do JY, Kim YL, Bahl Lee H, Davison SN, Topley N, Davies SJ, Lambie M. Biocompatible solutions and long-term changes in peritoneal solute transport. Clin J Am Soc Nephrol. 2018;13(10):1526–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Ethier I, Cho Y, Hawley C, Pascoe EM, Viecelli AK, Campbell SB, van Eps C, Isbel NM, Cooper BA, Harris DC, Pollock CA, Wong MG, Johnson DW. Rate of decline in residual kidney function pre and post peritoneal dialysis initiation: a post hoc analysis of the IDEAL study. PLoS One. 2020;15(11):e0242254.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Feber J, Schärer K, Schaefer F, Míková M, Janda J. Residual renal function in children on haemodialysis and peritoneal dialysis therapy. Pediatr Nephrol. 1994;8(5):579–83.

    Article  CAS  PubMed  Google Scholar 

  37. Feneberg R, Warady B, Alexander S, Schaefer F. The international pediatric peritonitis registry: a global internet-based initiative in pediatric dialysis. Perit Dial Int. 2005;25(Suppl 3):S130–4.

    PubMed  Google Scholar 

  38. Fischbach M, Terzic J, Becmeur F, Lahlou A, Desprez P, Battouche D, et al. Relationship between intraperitoneal hydrostatic pressure and dialysate volume in children on PD. Adv Perit Dial. 1996;12:330–4.

    CAS  PubMed  Google Scholar 

  39. Fischbach M, Terzic J, Menouer S, Haraldsson B. Optimal volume prescription for children on peritoneal dialysis. Perit Dial Int. 2000;20:603–6.

    Article  CAS  PubMed  Google Scholar 

  40. Fischbach M, Haraldsson B. Dynamic changes of total pore area available for peritoneal exchange in children. J Am Soc Nephrol. 2001;12:1524–9.

    Article  PubMed  Google Scholar 

  41. Fischbach M, Terzic J, Laugel V, Escande B, Dangelser C, Helmstetter A. Measurement of hydrostatic intraperitoneal pressure: a useful tool for the improvement of dialysis dose prescription. Pediatr Nephrol. 2003;18:976–80.

    Article  CAS  PubMed  Google Scholar 

  42. Fischbach M, Issad B, Dunois B, Taamma R. The beneficial influence on the effectiveness of automated peritoneal dialysis of varying the dwell time (short/long) and fill volume (small/large): a randomized controlled trial. Perit Dial Int. 2011;31:450–8.

    Article  PubMed  Google Scholar 

  43. Fischbach M, Schmitt CP, Shroff R, Zaloszyc A, Warady B. Increasing sodium removal on peritoneal dialysis: applying dialysis mechanics to the peritoneal dialysis prescription. Kidney Int. 2016;89:761–6.

    Article  CAS  PubMed  Google Scholar 

  44. Fischbach M, Zaloszyc A, Schaefer B, Schmitt CP. Should sodium removal in peritoneal dialysis be estimated from the ultrafiltration volume? Pediatr Nephrol. 2017;32:19–424.

    Article  Google Scholar 

  45. Flessner M, Henegar J, Bigler S, Genous L. Is the peritoneum a significant barrier in peritoneal dialysis? Perit Dial Int. 2003;23:542–9.

    Article  CAS  PubMed  Google Scholar 

  46. FuBholler A, Nieden S, Grabensee B, Plum J. Peritoneal fluid and solute transport: influence of treatment time, peritoneal Dialysis modality, and peritonitis incidence. J Am Soc Nephrol. 2002;13:1055–60.

    Article  Google Scholar 

  47. Gallar P, Vigil A, Rodriguez I, Ortega O, Gutierrez M, Hurtado J, Oliet A, Ortiz M, Mon C, Herrero JC, Lentisco C. Two-year experience with telemedicine in the follow-up of patients in home peritoneal dialysis. J Telemed Telecare. 2007;13(6):288–92.

    Article  PubMed  Google Scholar 

  48. Goldstein SL, Graham N, Warady BA, Seikaly M, McDonald R, Burwinkle TM, Limbers CA, Varni JW. Measuring health-related quality of life in children with ESRD: performance of the generic and ESRD-specific instrument of the pediatric quality of life inventory (PedsQL). Am J Kidney Dis. 2008;51(2):285–97.

    Article  PubMed  Google Scholar 

  49. Goossen K, Becker M, Marshall MR, Bühn S, Breuing J, Firanek CA, Hess S, Nariai H, Sloand JA, Yao Q, Chang TI, Chen J, Paniagua R, Takatori Y, Wada J, Pieper D. Icodextrin versus glucose solutions for the once-daily long dwell in peritoneal Dialysis: an enriched systematic review and meta-analysis of randomized controlled trials. Am J Kidney Dis. 2020;75(6):830–46.

    Article  CAS  PubMed  Google Scholar 

  50. He L, Liu X, Li Z, Abreu Z, Malavade T, et al. Rate of decline of residual kidney function before and after the start of peritoneal dialysis. Perit Dial Int. 2016;36:334–9.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Holtta TM, Ronnholm KA, Jalanko H, Ala-Houhala M, Antikainen M, Holmberg C. Peritoneal dialysis in children under 5 years of age. Perit Dial Int. 1997;17(6):573–80.

    Article  CAS  PubMed  Google Scholar 

  52. Honda M, Warady BA. Long-term peritoneal dialysis and encapsulating peritoneal sclerosis in children. Pediatr Nephrol. 2010;25(1):75–81.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Htay H, Johnson DW, Wiggins KJ, Badve SV, Craig JC, Strippoli GF, Cho Y. Biocompatible dialysis fluids for peritoneal dialysis. Meta-Anal Cochrane Database Syst Rev. 2018;10(10):CD007554.

    PubMed  Google Scholar 

  54. Iguchi A, Watanabe Y, Iino N, Kazama JJ, Iesato H, Narita I. Serum magnesium concentration is inversely associated with fibroblast growth factor 23 in haemodialysis patients. Nephrology. 2014;19(11):667–71.

    Article  CAS  PubMed  Google Scholar 

  55. Jagirdar RM, Bozikas A, Zarogiannis SG, Bartosova M, Schmitt CP, Liakopoulos V. Encapsulating peritoneal sclerosis: pathophysiology and current treatment options. Int J Mol Sci. 2019;20(22):5765.

    Article  CAS  PubMed Central  Google Scholar 

  56. Jain AK, Blake P, Cordy P, Garg AX. Global trends in rates of peritoneal dialysis. J Am Soc Nephrol. 2012;23(3):533–44.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Johnson DW, Brown FG, Clarke M, Boudville N, Elias TJ, Foo MW, Jones B, Kulkarni H, Langham R, Ranganathan D, Schollum J, Suranyi MG, Tan SH, Voss D. balANZ trial investigators. The effect of low glucose degradation product, neutral pH versus standard peritoneal dialysis solutions on peritoneal membrane function: the balANZ trial. Nephrol Dial Transplant. 2012a;27(12):4445–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Johnson DW, Brown FG, Clarke M, Boudville N, Elias TJ, Foo MW, Jones B, Kulkarni H, Langham R, Ranganathan D, Schollum J, Suranyi M, Tan SH, Voss D, balANZ Trial Investigators. Effects of biocompatible versus standard fluid on peritoneal dialysis outcomes. J Am Soc Nephrol. 2012b;23(6):1097–107. Htay H et al Cochrane Database Syst. Review 2018

    Article  PubMed  PubMed Central  Google Scholar 

  59. KDOQI. Clinical practice guidelines for peritoneal Dialysis adequacy. Am J Kidney Dis. 2006;48(1):s99–s102.

    Google Scholar 

  60. Keswani M, Redpath Mahon AC, Richardson T, Rodean J, Couloures O, Martin A, Blaszak RT, Warady BA, Neu A. Risk factors for early onset peritonitis: the SCOPE collaborative. Pediatr Nephrol. 2019;34(8):1387–94.

    Article  PubMed  Google Scholar 

  61. Krediet RT, Lindholm B, Rippe B. Pathophysiology of peritoneal membrane failure. Perit Dial Int. 2000;20(Suppl 4):S22–42.

    Article  PubMed  Google Scholar 

  62. Ku E, McCulloch CE, Grimes BA, Johansen KL. Racial and ethnic disparities in survival of children with ESRD. J Am Soc Nephrol. 2017;28(5):1584–91.

    Article  PubMed  Google Scholar 

  63. La Milia V, Di Filippo S, Crepaldi M, Del Vecchio L, Dell’Oro C, Andrulli S, Locatelli F. Mini-peritoneal equilibration test: a simple and fast method to assess free water and small solute transport across the peritoneal membrane. Kidney Int. 2005;68:840–6.

    Article  PubMed  Google Scholar 

  64. La Milia V, Pozzoni P, Virga G, Crepaldi M, Del Vecchio L, Andrulli S. Locatelli F peritoneal transport assessment by peritoneal equilibration test with 3.86% glucose: a long-term prospective evaluation. Kidney Int. 2006;69:927–33.

    Article  PubMed  CAS  Google Scholar 

  65. Laakkonen H, Holtta T, Lonnqvist T, Holmberg C, Ronnholm K. Peritoneal dialysis in children under two years of age. Nephrol Dial Transplant. 2008;23(5):1747–53.

    Article  PubMed  Google Scholar 

  66. Lane JC, Warady BA, Feneberg R, Majkowski NL, Watson AR, Fischbach M, Kang HG, Bonzel KE, Simkova E, Stefanidis CJ, Klaus G, Alexander SR, Ekim M, Bilge I, Schaefer F. Relapsing peritonitis in children who undergo chronic peritoneal dialysis: a prospective study of the international pediatric peritonitis registry. Clin J Am Soc Nephrol. 2010;5(6):1041–6.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Lilaj T, Vychytil A, Schneider B, Hörl WH, Haag-Weber M. Influence of the preceding exchange on peritoneal equilibration test results: a prospective study. Am J Kidney Dis. 1999;34:247–53.

    Article  CAS  PubMed  Google Scholar 

  68. Lo WK, Ho YW, Li CS, et al. Effect of Kt/V on survival and clinical outcome in CAPD patients in a randomized prospective study. Kidney Int. 2003;64:649–56.

    Article  PubMed  Google Scholar 

  69. Manera KE, Johnson DW, Craig JC, Shen JI, Gutman T, Cho Y, Wang AY, Brown EA, Brunier G, Dong J, Dunning T, Mehrotra R, Naicker S, Pecoits-Filho R, Perl J, Wilkie M, Tong A, SONG-PD Workshop Investigators. Establishing a Core outcome set for peritoneal Dialysis: report of the SONG-PD (Standardized Outcomes in Nephrology-Peritoneal Dialysis) consensus workshop. Am J Kidney Dis. 2020;75(3):404–12.

    Article  PubMed  Google Scholar 

  70. McCormick BB, Bargman JM. Noninfectious complications of peritoneal dialysis: implications for patient and technique survival. J Am Soc Nephrol. 2007;18(12):3023–5.

    Article  PubMed  Google Scholar 

  71. McDonald SP, Russ GR, Kerr PG, Collins JF. ESRD in Australia and New Zealand at the end of the millennium: a report from the ANZDATA registry. Am J Kidney Dis. 2002;40(6):1122–31.

    Article  PubMed  Google Scholar 

  72. Misra M, Vonesh E, Van Stone JC, Moore HL, Prowant B, Nolph KD. Effect of cause and time of dropout on the residual GFR: a comparative analysis of the decline of GFR on dialysis. Kidney Int. 2001;59(2):754–63.

    Article  CAS  PubMed  Google Scholar 

  73. Mitsnefes MM, Laskin BL, Dahhou M, Zhang X, Foster BJ. Mortality risk among children initially treated with dialysis for end-stage kidney disease, 1990-2010. JAMA. 2013;309(18):1921–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Morgenstern B, Mahoney D, Warady B. Estimating Total body water in children on the basis of height and weight: a reevaluation of the formulas of Mellits and cheek. J Am Soc Nephrol. 2002;13:1884–8.

    Article  PubMed  Google Scholar 

  75. Neu AM, Sander A, Borzych-Duzalka D, Watson AR, Vallés PG, Ha IS, Patel H, Askenazi D, Balasz-Chmielewska I, Lauronen J, Groothoff JW, Feber J, Schaefer F, Warady BA. Comorbidities in chronic pediatric peritoneal dialysis patients: a report of the international pediatric peritoneal Dialysis network. Perit Dial Int. 2012;32(4):410–8.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Neu AM, Miller MR, Stuart J, Lawlor J, Richardson T, Martz K, Rosenberg C, Newland J, McAfee N, Begin B, Warady BA. Design of the standardizing care to improve outcomes in pediatric end stage renal disease collaborative. Pediatr Nephrol. 2014;29(9):1477–84.

    Article  PubMed  Google Scholar 

  77. Neu AM, Richardson T, Lawlor J, Stuart J, Newland J, McAfee N, Warady BA. Implementation of standardized follow-up care significantly reduces peritonitis in children on chronic peritoneal dialysis. Kidney Int. 2016;89(6):1346–54.

    Article  PubMed  Google Scholar 

  78. North American Pediatric Renal Trials and Collaborative Studies. NAPRTCS 2011 Annual Dialysis Report [online], https://web.emmes.com/study/ped/annlrept/annualrept2011.pdf (2011).

  79. Ohya M, Negi S, Sakaguchi T, Koiwa F, Ando R, Komatsu Y, Shinoda T, Inaguma D, Joki N, Yamaka T, Ikeda M, Shigematsu T. Significance of serum magnesium as an independent correlative factor on the parathyroid hormone level in uremic patients. J Clin Endocrinol Metabol. 2014;99(10):3873–8.

    Article  CAS  Google Scholar 

  80. Paniagua R, Amato D, Vonesh E, Correa-Rotter R, Ramos A, Moran J, et al. Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomized, controlled trial. J Am Soc Nephrol. 2002;13:1307–20.

    Article  CAS  PubMed  Google Scholar 

  81. Phadke K, Bitzan M, Shetty S. Chronic Dialysis, in: Manual of pediatric nephrology 2017. From Phadke K, Goodyer P, Bitzan M, Editors., ISBN 978-3-642-12482-2 ISBN 978-3-642-12483-9 (eBook), DOI https://doi.org/10.1007/978-3-642-12483-9, Springer Heidelberg New York/Dordrecht/London.

  82. Piraino B. Peritoneal infections. Adv Ren Replace Ther. 2000;7(4):280–8.

    Article  CAS  PubMed  Google Scholar 

  83. Piraino B, Bernardini J, Florio T, Fried L. Staphylococcus aureus prophylaxis and trends in gram-negative infections in peritoneal dialysis patients. Perit Dial Int. 2003;23(5):456–9.

    Article  PubMed  Google Scholar 

  84. Prowant BF, Twardowski ZJ. Recommendations for exit care. Perit Dial Int. 1996;16(Suppl 3):S94–s99.

    Article  PubMed  Google Scholar 

  85. Rahim KA, Seidel K, McDonald RA. Risk factors for catheter-related complications in pediatric peritoneal dialysis. Pediatr Nephrol. 2004;19(9):1021–8.

    Article  PubMed  Google Scholar 

  86. Rees L. Assessment of dialysis adequacy: beyond urea kinetic measurements. Pediatr Nephrol. 2019;35:61–9.

    Article  Google Scholar 

  87. Rinaldi S, Sera F, Verrina E, Edefonti A, Gianoglio B, Perfumo F, Sorino P, Zacchello G, Cutaia I, Lavoratti G, Leozappa G, Pecoraro C, Rizzoni G. Chronic peritoneal dialysis catheters in children: a fifteen-year experience of the Italian registry of pediatric chronic peritoneal Dialysis. Perit Dial Int. 2004;24(5):481–6.

    Article  PubMed  Google Scholar 

  88. Rippe B, Stelin G, Haraldsson B. Computer simulations of peritoneal fluid transport in CAPD. Kidney Int. 1991;40(2):315–25.

    Article  CAS  PubMed  Google Scholar 

  89. Rosengren BI, Rippe B. Blood flow limitation in vivo of small solute transfer during peritoneal dialysis in rats. J Am Soc Nephrol. 2003;14(6):1599–604.

    Article  PubMed  Google Scholar 

  90. Rusthoven E, Krediet RT, Willems HL, Monnens LA, Schröder CH. Sodium sieving in children. Perit Dial Int. 2005;25(Suppl 3):S141–2.

    Article  CAS  PubMed  Google Scholar 

  91. Saland JM, Pierce CB, Mitsnefes MM, Flynn JT, Goebel J, Kupferman JC, Warady BA, Furth SL. Dyslipidemia in children with chronic kidney disease. Kidney Int. 2010;78(11):1154–63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Sanderson KR, Yu Y, Dai H, Willik LK, Warady BA. Outcomes of infants receiving chronic peritoneal dialysis: an analysis of the USRDS registry. Outcomes of infants receiving chronic peritoneal dialysis: an analysis of the USRDS registry. Pediatr Nephrol. 2019;34(1):155–62.

    Article  PubMed  Google Scholar 

  93. Schaefer F, Klaus G, Muller-Wiefel DE, Mehls O. Intermittent versus continuous intraperitoneal glycopeptide/ceftazidime treatment in children with peritoneal dialysis-associated peritonitis. The Mid-European Pediatric Peritoneal Dialysis Study Group (MEPPS). J Am Soc Nephrol. 1999;10(1):136–45.

    Article  CAS  PubMed  Google Scholar 

  94. Schaefer F, Feneberg R, Aksu N, Donmez O, Sadikoglu B, Alexander SR, Mir S, Ha IS, Fischbach M, Simkova E, Watson AR, Moller K, von Baum H, Warady BA. Worldwide variation of dialysis-associated peritonitis in children. Kidney Int. 2007;72(11):1374–9.

    Article  CAS  PubMed  Google Scholar 

  95. Schaefer F, Borzych-Duzalka D, Azocar M, Munarriz RL, Sever L, Aksu N, Barbosa LS, Galan YS, Xu H, Coccia PA, Szabo A, Wong W, Salim R, Vidal E, Pottoore S, Warady BA. Impact of global economic disparities on practices and outcomes of chronic peritoneal dialysis in children: insights from the international pediatric peritoneal Dialysis network registry. Perit Dial Int. 2012;32(4):399–409.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Schaefer B, Bartosova M, Macher-Goeppinger S, Ujszaszi A, Wallwiener M, Nyarangi-Dix J, Sallay P, Burkhardt D, Querfeld U, Pfeifle V, Lahrmann B, Schwenger V, WĂĽhl E, Holland-Cunz S, Schaefer F, Schmitt CP. Quantitative Histomorphometry of the healthy peritoneum. Sci Rep. 2016;6:21344.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Schaefer B, Bartosova M, Macher-Goeppinger S, Sallay P, Vörös P, Ranchin B, Vondrak K, Ariceta G, Zaloszyc A, Bayazit AK, Querfeld U, Cerkauskiene R, Testa S, Taylan C, Vande Walle J, Yap Y, Krmar RT, Büscher R, Mühlig AK, Drozdz D, Caliskan S, Lasitschka F, Fathallah-Shaykh S, Verrina E, Klaus G, Arbeiter K, Bhayadia R, Melk A, Romero P, Warady BA, Schaefer F, Ujszaszi A, Schmitt CP. Neutral pH and low-glucose degradation product dialysis fluids induce major early alterations of the peritoneal membrane in children on peritoneal dialysis. Kidney Int. 2018;94(2):419–29.

    Article  CAS  PubMed  Google Scholar 

  98. Schmitt CP, Dötschmann R, Daschner M, Zimmering M, Greiner C, Böswald M, Klaus G, Schaefer F. Residual peritoneal volume and body size in children on peritoneal dialysis. [Members of the Mid European Pediatric Peritoneal Dialysis Study Group (MEPPS)]. Adv Perit Dial. 1999;15:287–90.

    CAS  PubMed  Google Scholar 

  99. Schmitt CP, Haraldsson B, Doetschmann R, Zimmering M, Greiner C, Böswald M, Klaus G, Passlick-Deetjen J, Schaefer F. Effects of pH-neutral, bicarbonate-buffered dialysis fluid on peritoneal transport in children. Kidney Int. 2002;61:1527–36.

    Article  PubMed  Google Scholar 

  100. Schmitt CP, Bakkaloglu S, Klaus G, Schröder C, Fischbach M. Solutions for peritoneal dialysis in children: recommendations by the European Pediatric Dialysis Working Group. Pediatr Nephrol. 2011;26:1137–47.

    Article  PubMed  Google Scholar 

  101. Schmitt CP, Nau B, Gemulla G, Bonzel KE, Hölttä T, Testa S, Fischbach M, John U, Kemper MJ, Sander A, Arbeiter K, Schaefer F. Effect of the dialysis fluid buffer on peritoneal membrane function in children. Clin J Am Soc Nephrol. 2013;8(1):108–15.

    Article  CAS  PubMed  Google Scholar 

  102. Sethna CB, Bryant K, Munshi R, Warady BA, Richardson T, Lawlor J, Newland JG, Neu A. Risk factors for and outcomes of catheter-associated peritonitis in children: the SCOPE collaborative. Clin J Am Soc Nephrol. 2016;11(9):1590–6.

    Article  PubMed  PubMed Central  Google Scholar 

  103. Shroff R, Stefanidis CJ, Askiti V, Edefonti A, Testa S, Ekim M, Kavaz A, Ariceta G, Bakkaloglu S, Fischbach M, Klaus G, Zurowska A, Holtta T, Jankauskiene A, Vondrak K, Vande Walle J, Schmitt CP. Watson AR; European Paediatric Dialysis working group. Encapsulating peritoneal sclerosis in children on chronic PD: a survey from the European Paediatric Dialysis working group. Nephrol Dial Transplant. 2013;28(7):1908–14.

    Article  CAS  PubMed  Google Scholar 

  104. Stachowska-Pietka J, Poleszczuk J, Flessner MF, Lindholm B, Waniewski J. Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components. Nephrol Dial Transplant. 2019;34(5):864–70.

    Article  CAS  PubMed  Google Scholar 

  105. Strippoli GF, Tong A, Johnson D, Schena FP, Craig JC. Antimicrobial agents to prevent peritonitis in peritoneal dialysis: a systematic review of randomized controlled trials. Am J Kidney Dis. 2004;44(4):591–603.

    Article  CAS  PubMed  Google Scholar 

  106. Swartz SJ, Neu A, Skversky Mason A, Richardson T, Rodean J, Lawlor J, Warady B, Somers MJG. Exit site and tunnel infections in children on chronic peritoneal dialysis: findings from the Standardizing Care to Improve Outcomes in Pediatric End Stage Renal Disease (SCOPE) collaborative. Pediatr Nephrol. 2018;33(6):1029–35.

    Article  PubMed  Google Scholar 

  107. System, U. S. R. D. 2018 USRDS annual data report: epidemiology of kidney disease in the United States. Bethesda, MD: N. I. o. D. a. D. a. K. D. National Institutes of Health; 2018.

    Google Scholar 

  108. Szeto CC, Chow KM. Pathogenesis and management of hydrothorax complicating peritoneal dialysis. Curr Opin Pulm Med. 2004;10(4):315–9.

    Article  PubMed  Google Scholar 

  109. Szeto CC, Li PK, Johnson DW, Bernardini J, Dong J, Figueiredo AE, Ito Y, Kazancioglu R, Moraes T, Van Esch S, Brown EA. ISPD catheter-related infection recommendations: 2017 update. Perit Dial Int. 2017;37(2):141–54.

    Article  PubMed  Google Scholar 

  110. Tenckhoff HA, Schechter HA. Bacteriologically safe peritoneal access device. Trans Am Soc Artif Intern Organs. 1973;19:363–70.

    Google Scholar 

  111. Twardowski ZJ, Nolph KD, Khanna R, Prowant BF, Ryan LP, Moore HL, Nielsen MP. Peritoneal equilibration test. Perit Dial Bull. 1987;3:138–47.

    Google Scholar 

  112. Twardowski ZJ, Prowant BF, Moore HL, Lou LC, White E, Farris K. Short peritoneal equilibration test: impact of preceding dwell time. Adv Perit Dial. 2003;19:53–8.

    PubMed  Google Scholar 

  113. Van Esch S, Struijk DG, Krediet RT. The natural time course of membrane alterations during peritoneal Dialysis is partly altered by peritonitis. Perit Dial Int. 2016;36(4):448–56.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  114. van Stralen KJ, Borzych-Duzalka D, Hataya H, Kennedy SE, Jager KJ, Verrina E, Inward C, Ronnholm K, Vondrak K, Warady BA, Zurowska AM, Schaefer F, Cochat P. Survival and clinical outcomes of children starting renal replacement therapy in the neonatal period. Kidney Int. 2014;86(1):168–74.

    Article  PubMed  Google Scholar 

  115. Verrina E, Cappelli V, Perfumo F. Selection of modalities, prescription, and technical issues in children on peritoneal dialysis. Pediatr Nephrol. 2009;24:1453–64.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Vidal E, Edefonti A, Puteo F, Chimenz R, Gianoglio B, Lavoratti G, Leozappa G, Maringhini S, Mencarelli F, Pecoraro C, Ratsch IM, Cannavò R, De Palo T, Testa S, Murer L, Verrina E. Italian registry of pediatric chronic Dialysis. Encapsulating peritoneal sclerosis in paediatric peritoneal dialysis patients: the experience of the Italian registry of pediatric chronic Dialysis. Nephrol Dial Transplant. 2013;28(6):1603–9.

    Article  CAS  PubMed  Google Scholar 

  117. Vidal E, Chesnaye NC, Paglialonga F, Minale B, Leozappa G, Giordano M, Gianoglio B, Corrado C, Roperto RM, Chimenz R, Mencarelli F, Ratsch IM, Murer L, Verrina E. A propensity-matched comparison of hard outcomes in children on chronic dialysis. Eur J Pediatr. 2018;177(1):117–24.

    Article  PubMed  Google Scholar 

  118. Vychytil A, Herzog R, Probst P, Ribitsch W, Lhotta K, Machold-Fabrizii V, Wiesholzer M, Kaufmann M, Salmhofer H, Windpessl M, Rosenkranz AR, Oberbauer R, König F, Kratochwill K, Aufricht C. A randomized controlled trial of alanyl-glutamine supplementation in peritoneal dialysis fluid to assess impact on biomarkers of peritoneal health. Kidney Int. 2018;94(6):1227–37.

    Article  CAS  PubMed  Google Scholar 

  119. Wallace EL, Rosner MH, Alscher MD, Schmitt CP, Jain A, Tentori F, Firanek C, Rheuban KS, Florez-Arango J, Jha V, Foo M, de Blok K, Marshall MR, Sanabria M, Kudelka T, Sloand JA. Remote patient Management for Home Dialysis Patients. Kidney Int Rep. 2017;2(6):1009–17.

    Article  PubMed  PubMed Central  Google Scholar 

  120. Wanner C, Tonelli M. KDIGO clinical practice guideline for lipid management in CKD: summary of recommendation statements and clinical approach to the patient. Kidney Int. 2014;85(6):1303–9.

    Article  CAS  PubMed  Google Scholar 

  121. Warady B, Jennings J. The short PET in pediatrics. Perit Dial Int. 2007;27:441–5.

    Article  CAS  PubMed  Google Scholar 

  122. Warady BA, Alexander SA, Hossli S, Vonesh E, Geary D, Watkins S, Salusky IB, Kohaut EC. Peritoneal membrane transport function in children receiving long-term dialysis. J Am Soc Nephrol. 1996;7(11):2385–91.

    Article  CAS  PubMed  Google Scholar 

  123. Warady BA, Bakkaloglu S, Newland J, et al. Consensus guidelines for the prevention and treatment of catheter-related infections and peritonitis in pediatric patients receiving peritoneal dialysis: 2012 update. Perit Dial Int. 2012;32(Suppl 2):S32–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  124. Warady B, Schaefer F, Alexander S, editors. Pediatric Dialysis case studies, a practical guide to patient care. Springer International Publishing AG; 2017. ISBN 978-3-319-55145-6, ISBN 978-3-319-55147-0 (eBook). https://doi.org/10.1007/978-3-319-55147-0.

  125. Warady B, Borzych-Duzalka D, Schaefer F. World wide experience with peritonitis in children: a report from the International Pediatric Peritoneal Dialysis Network (IPPN). Perit Dial Int. 2019;39(Suppl 1):S10–4.

    Google Scholar 

  126. Warady B, Schaefer F, Bagga A, Cano F, McCulloch M, Shroff R. Prescribing peritoneal dialysis for high-quality care in children. Perit Dial Int. 2020;40(3):333–40.

    Article  PubMed  Google Scholar 

  127. Watson AR. Stress and burden of care in families with children commencing renal replacement therapy. Adv Perit Dial. 1997;13:300–4.

    CAS  PubMed  Google Scholar 

  128. Weaver DJ Jr, Somers MJG, Martz K, Mitsnefes MM. Clinical outcomes and survival in pediatric patients initiating chronic dialysis: a report of the NAPRTCS registry. Pediatr Nephrol. 2017;32(12):2319–30.

    Article  PubMed  Google Scholar 

  129. Wei M, Esbaei K, Bargman J, Oreopoulos DG. Relationship between serum magnesium, parathyroid hormone, and vascular calcification in patients on dialysis: a literature review. Perit Dial Int. 2006a;26(3):366–73.

    Article  CAS  PubMed  Google Scholar 

  130. Wei M, Esbaei K, Bargman JM, Oreopoulos DG. Inverse correlation between serum magnesium and parathyroid hormone in peritoneal dialysis patients: a contributing factor to adynamic bone disease? Int Urol Nephrol. 2006b;38(2):317–22.

    Article  CAS  PubMed  Google Scholar 

  131. Williams JD, Craig KJ, Topley N, Von Ruhland C, Fallon M, Newman GR, Mackenzie RK, Williams GT. Peritoneal biopsy study group. Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol. 2002;13(2):470–9.

    Article  PubMed  Google Scholar 

  132. Wilson AC, Schneider MF, Cox C, Greenbaum LA, Saland J, White CT, Furth S, Warady BA, Mitsnefes MM. Prevalence and correlates of multiple cardiovascular risk factors in children with chronic kidney disease. Clin J Am Soc Nephrol. 2011;6(12):2759–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Yáñez-Mó M, Lara-Pezzi E, Selgas R, Ramírez-Huesca M, Domínguez-Jiménez C, Jiménez-Heffernan JA, Aguilera A, Sánchez-Tomero JA, Bajo MA, Alvarez V, Castro MA, del Peso G, Cirujeda A, Gamallo C, Sánchez-Madrid F, López-Cabrera M. Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med. 2003;348(5):403–13.

    Article  PubMed  Google Scholar 

  134. Zorzanello MM, Fleming WJ, Prowant BE. Use of tissue plasminogen activator in peritoneal dialysis catheters: a literature review and one center's experience. Nephrol Nurs J. 2004;31(5):534–7.

    PubMed  Google Scholar 

  135. Zurowska A, Feneberg R, Warady BA, Zimmering M, Monteverde M, Testa S, Calyskan S, Drozdz D, Salusky I, Kemper MJ, Ekim M, Verrina E, Misselwitz J, Schaefer F. Gram-negative peritonitis in children undergoing long-term peritoneal dialysis. Am J Kidney Dis. 2008;51(3):455–62.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, Heidelberg, Germany

    C. P. Schmitt

  2. Pediatric Nephrology, Luis Calvo Mackenna Children’s Hospital, University of Chile, Santiago, Chile

    F. Cano

  3. Pediatric Nephrology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    A. Neu

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  1. C. P. Schmitt
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  2. F. Cano
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  3. A. Neu
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Correspondence to C. P. Schmitt .

Editor information

Editors and Affiliations

  1. Division of Nephrology, Bambino Gesù Children’s Hospital –, ROMA, Roma, Italy

    Francesco Emma

  2. Division of Nephrology and Hypertension The Heart Institute, University of Cincinnati Cincinnati Children’s Hospital Medical C, Cincinnati, OH, USA

    Stuart Goldstein

  3. Division of Nephrology, All India Institute of Medical Sciences, Ansari Nagar East, Delhi, India

    Arvind Bagga

  4. Division of Pediatric Nephrology, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA

    Carlton M. Bates

  5. Renal Unit, Graet Ormond Street Hospital, London, UK

    Rukshana Shroff

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Schmitt, C.P., Cano, F., Neu, A. (2021). Peritoneal Dialysis. In: Emma, F., Goldstein, S., Bagga, A., Bates, C.M., Shroff, R. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27843-3_132-1

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