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Histology of Microvascular Aging of Human Skin

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Textbook of Aging Skin

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Abstract

In this chapter, various histological studies regarding the role of pericytes (PC) in the dermis will be summarized, focusing on dermal microvascular aging (Helmbold P et al. J Invest Dermatol 126:1419–21, 2006; Helmbold P et al. J Cutan Pathol 28:206–10, 2001; Helmbold P et al. J Cutan Pathol 31:431–40, 2004; Helmbold P. Methodische Grundlagen zur Erforschung von Perizyten der Haut. In: Medizinische Fakultät. Halle (Saale): Martin-Luther-Universität Halle, Wittenberg; 2002.). Aging of the dermis proceeds under special conditions. In addition to chronological aging, a powerful extrinsic factor – chronic UV light – leads to photoaging (actinic or solar aging). Some known facultative intrinsic or extrinsic factors that influence dermal aging include diabetes mellitus, alcohol, cigarette smoking, and genodermatoses like progeria (Clin Geriatr Med 5:69–90, 1989; Kardiologiia 16:19–25, 1976; J Rheumatol 27:797–800, 2000; Br J Dermatol 147:1187–91). Previous studies have shown that human dermal microvessel densities depend on age with reduction of functioning reserve capillaries, and there are typical ultrastructural changes in the microvasculature of elderly individuals (Clin Geriatr Med 5:69–90, 1989; Kardiologiia 16:19–25, 1976; Arch Dermatol 138:1437–42, 2002).

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Author information

Authors and Affiliations

  1. Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, D-69120, Heidelberg, Germany

    Peter Helmbold

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  1. Peter Helmbold
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Correspondence to Peter Helmbold .

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Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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Helmbold, P. (2015). Histology of Microvascular Aging of Human Skin. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_2-2

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  • DOI: https://doi.org/10.1007/978-3-642-27814-3_2-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27814-3

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