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Therapeutic Alternatives for the Treatment of Epidermal Aging

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Textbook of Aging Skin

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Abstract

Over a lifetime, the epidermal layer of skin changes in structure and functionality, which contributes to the appearance of the clinical signs that characterize cutaneous aging, such as the appearance of wrinkles and pigmentation disorders, hydration dysfunction, and even cancer development. The search for effective treatments should consider the main biological functions of the epidermis affected by aging, including cell renewal and barrier integrity, antioxidant mechanisms and response to ultraviolet (UV) radiation, water-ion balance, and epidermal defense mechanisms. Several natural extracts and isolated compounds have been suggested in the literature as antiaging agents. However, a critical evaluation is essential to understand their mechanisms of action and how they could contribute to the development of promising therapeutic alternatives, in particular for the specific case of epidermal aging.

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Authors and Affiliations

  1. R&D Department, Grupo Boticário, Rua Alfredo Pinto, 1500, 83065-150, São José dos Pinhais, PR, Brazil

    Carla Abdo Brohem, Valéria Maria Di Mambro & Márcio Lorencini

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  1. Carla Abdo Brohem
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  2. Valéria Maria Di Mambro
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  3. Márcio Lorencini
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Correspondence to Márcio Lorencini .

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Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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Brohem, C.A., Di Mambro, V.M., Lorencini, M. (2015). Therapeutic Alternatives for the Treatment of Epidermal Aging. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_140-1

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