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Antitussive Activity

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

Cough is thought to be caused by a reflex. The sensitive receptors are located in the bronchial tree, particularly in the bifurcation of the trachea. These receptors can be stimulated mechanically or chemically, e.g., by inhalation of various irritants. Nerve impulses then activate the cough center in the brain. Several animal species and several irritants have been used, most frequently the citric acid–induced cough in guinea pigs (Charlier et al. 1961; Karlsson et al. 1989; Braga et al. 1993). The pharmacology of cough was reviewed by Reynolds et al. (2004).

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  1. Integrated Physiology & Pharmacology Consulting, LLC, 25 Bedell Rd, Poughkeepsie, NY, 12603, USA

    Kristy D. Bruse

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  1. Kristy D. Bruse
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Correspondence to Kristy D. Bruse .

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  1. Dieburg, Germany

    Franz J. Hock

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Bruse, K.D. (2015). Antitussive Activity. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_24-1

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  • DOI: https://doi.org/10.1007/978-3-642-27728-3_24-1

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  • Online ISBN: 978-3-642-27728-3

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