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Triterpenoid Saponins: A Focus on Polygalaceae

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Abstract

The aim of this chapter is to give the newest results on the chemistry and pharmacological properties of Polygalaceae saponins during the period 2005–2012. Around 60 new triterpene saponins were isolated and characterized, having mainly presenegenin, medicagenic acid, their 2-oxo or 11-oxo structural analogs, and bayogenin as aglycone. The sequence 3-O-(β-d-glucopyranosyl)presenegenin 28-{O-β-d-xylopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→2)-β-d-fucopyranosyl} ester often encountered in the genera Polygala, Securidaca, and Atroxima supported our previous conclusions that they may represent a chemotaxonomic marker for the Polygalaceae family. Additional glycosylations and acylations with 4-methoxy-, 3,4-dimethoxy-, or 3,4,5-trimethoxycinnamoyl groups contribute to the great chemical diversity of these saponins. The promising potential of the Polygalaceae saponins as immunoadjuvant, antiproliferative, anti-inflammatory, hypolipidemic, antidepressant, neuroprotective, and cognitive enhancer compounds has been highlighted.

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Authors and Affiliations

  1. Laboratoire de Pharmacognosie, EA 4267 (FDE/UFC), Faculté de Pharmacie, Université de Bourgogne, 7, Bd Jeanne d’Arc, 21079, Dijon, France

    Prof. Marie-Aleth Lacaille-Dubois & Anne-Claire Mitaine-Offer

  2. Centre de Recherche Phytochimique, Université de Liège, Institut de Chimie-B6, Sart Tilman, 4000, Liège, Belgium

    Clément Delaude

Authors
  1. Prof. Marie-Aleth Lacaille-Dubois
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  2. Clément Delaude
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  3. Anne-Claire Mitaine-Offer
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Corresponding author

Correspondence to Marie-Aleth Lacaille-Dubois .

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Editors and Affiliations

  1. Botany Department, M.L. Sukhadia University, Durga Nursery Road, Udaipur, 313001, Rajasthan, India

    Kishan Gopal Ramawat

  2. Institute of Vine and Wine Sciences, Biological-Active Plant Substances Study, University of Bordeaux, 210 Chemin de Leysotte CS 50008, Villenave d'Ornon, 33882, France

    Jean-Michel Mérillon

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Lacaille-Dubois, MA., Delaude, C., Mitaine-Offer, AC. (2013). Triterpenoid Saponins: A Focus on Polygalaceae. In: Ramawat, K., Mérillon, JM. (eds) Natural Products. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22144-6_138

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