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Non-squamous Malignant Disease of the Vagina

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Abdominal Imaging

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Abstract

This chapter reviews the clinical and imaging features of other malignant diseases involving the vagina but excluding primary vaginal squamous cell carcinoma (see Chap. 147). These other malignancies are a very heterogeneous group and very rare apart from secondary malignancy affecting the vagina. The data and descriptions of these other primary malignancies are limited to case reports or small case series. The diagnosis and staging of these other primary tumors are similar to primary squamous cell vaginal cancer. The diagnosis is made at examination under anesthesia (EUA) and biopsy of the macroscopic lesion. These tumors are staged using the clinical FIGO staging system. However, the treatment, prognosis, and imaging are dependent on the underlying histology of the primary.

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References

  • Allen SD, Moskovic EC, et al. Adult rhabdomyosarcoma: cross-sectional imaging findings including histopathologic correlation. AJR Am J Roentgenol. 2007;189(2):371–7.

    Article  PubMed  Google Scholar 

  • Baloglu A, Bezircioglu I, et al. Primary malignant melanoma of the vagina. Arch Gynecol Obstet. 2009;280(5):819–22.

    Article  PubMed  Google Scholar 

  • Cantisani V, Mortele KJ, et al. Vaginal metastasis from uterine leiomyosarcoma. Magnetic resonance imaging features with pathological correlation. J Comput Assist Tomogr. 2003;27(5):805–9.

    Article  PubMed  Google Scholar 

  • Chagpar A, Kanthan SC. Vaginal metastasis of colon cancer. Am Surg. 2001;67(2):171–2.

    PubMed  CAS  Google Scholar 

  • Chang YC, Hricak H, et al. Vagina: evaluation with MR imaging. Part II. Neoplasms. Radiology. 1988;169(1):175–9.

    PubMed  CAS  Google Scholar 

  • Chorlton I, Karnei Jr RF, et al. Primary malignant reticuloendothelial disease involving the vagina, cervix, and corpus uteri. Obstet Gynecol. 1974;44(5):735–48.

    PubMed  CAS  Google Scholar 

  • Ciaravino G, Kapp DS, et al. Primary leiomyosarcoma of the vagina. A case report and literature review. Int J Gynecol Cancer. 2000;10(4):340–7.

    Article  PubMed  Google Scholar 

  • Dhar KK, Das N, et al. Utility of sentinel node biopsy in vulvar and vaginal melanoma: report of two cases and review of the literature. Int J Gynecol Cancer. 2007;17(3):720–3.

    Article  PubMed  CAS  Google Scholar 

  • Fan SF, Gu WZ, et al. Case report: MR findings of malignant melanoma of the vagina. Br J Radiol. 2001;74(881):445–7.

    PubMed  CAS  Google Scholar 

  • Ghaemmaghami F, Karimi Zarchi M, et al. Lower genital tract rhabdomyosarcoma: case series and literature review. Arch Gynecol Obstet. 2008;278(1):65–9.

    Article  PubMed  Google Scholar 

  • Hatch EE, Palmer JR, et al. Cancer risk in women exposed to diethylstilbestrol in utero. JAMA. 1998;280(7):630–4.

    Article  PubMed  CAS  Google Scholar 

  • Kaminski JM, Anderson PR, et al. Primary small cell carcinoma of the vagina. Gynecol Oncol. 2003;88(3):451–5.

    Article  PubMed  Google Scholar 

  • Kim H, Jung SE, et al. Case report: magnetic resonance imaging of vaginal malignant melanoma. J Comput Assist Tomogr. 2003;27(3):357–60.

    Article  PubMed  Google Scholar 

  • Kim W, Menda Y, et al. Use of lymphoscintigraphy with SPECT/CT for sentinel node localization in a case of vaginal melanoma. Clin Nucl Med. 2006;31(4):201–2.

    Article  PubMed  Google Scholar 

  • Kobi M, Khatri G, et al. Sarcoma botryoides: MRI findings in two patients. J Magn Reson Imaging. 2009;29(3):708–12.

    Article  PubMed  Google Scholar 

  • Mazur MT, Hsueh S, et al. Metastases to the female genital tract. Analysis of 325 cases. Cancer. 1984;53(9):1978–84.

    Article  PubMed  CAS  Google Scholar 

  • McNicholas MM, Fennelly JJ, et al. Imaging of primary vaginal lymphoma. Clin Radiol. 1994;49(2):130–2.

    Article  PubMed  CAS  Google Scholar 

  • Merino MJ. Vaginal cancer: the role of infectious and environmental factors. Am J Obstet Gynecol. 1991;165(4 Pt 2):1255–62.

    Article  PubMed  CAS  Google Scholar 

  • Miyakawa I, Yasuda H, et al. Leiomyosarcoma of the vagina. Int J Gynaecol Obstet. 1985;23(3):213–6.

    Article  PubMed  CAS  Google Scholar 

  • Moon WK, Kim SH, et al. MR findings of malignant melanoma of the vagina. Clin Radiol. 1993;48(5):326–8.

    Article  PubMed  CAS  Google Scholar 

  • Nasu K, Kai K, et al. Primary mucinous adenocarcinoma of the vagina. Eur J Gynaecol Oncol. 2010;31(6):679–81.

    PubMed  CAS  Google Scholar 

  • Nomoto K, Hori T, et al. Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy. Pathol Int. 2010;60(9):636–41.

    Article  PubMed  Google Scholar 

  • Oudoux A, Rousseau T, et al. Interest of F-18 fluorodeoxyglucose positron emission tomography in the evaluation of vaginal malignant melanoma. Gynecol Oncol. 2004;95(3):765–8.

    Article  PubMed  CAS  Google Scholar 

  • Parikh JH, Barton DP, et al. MR imaging features of vaginal malignancies. Radiographics. 2008;28(1):49–63. quiz 322.

    Article  PubMed  Google Scholar 

  • Patnana M, Bronstein Y, et al. Multimethod imaging, staging, and spectrum of manifestations of metastatic melanoma. Clin Radiol. 2011;66(3):224–36.

    Article  PubMed  CAS  Google Scholar 

  • Perren T, Farrant M, et al. Lymphomas of the cervix and upper vagina: a report of five cases and a review of the literature. Gynecol Oncol. 1992;44(1):87–95.

    Article  PubMed  CAS  Google Scholar 

  • Pineda A, Sall S. Metastasis to the vagina from carcinoma of the breast. J Reprod Med. 1978;20(5):243–5.

    PubMed  CAS  Google Scholar 

  • Queiroz C, Bacchi CE, et al. Cytologic diagnosis of vaginal metastasis from renal cell carcinoma. A case report. Acta Cytol. 1999;43(6):1098–100.

    Article  PubMed  CAS  Google Scholar 

  • Saitoh M, Hayasaka T, et al. Primary mucinous adenocarcinoma of the vagina: possibility of differentiating from metastatic adenocarcinomas. Pathol Int. 2005;55(6):372–5.

    Article  PubMed  Google Scholar 

  • Shadbolt CL, Coakley FV, et al. MRI of vaginal leiomyomas. J Comput Assist Tomogr. 2001;25(3):355–7.

    Article  PubMed  CAS  Google Scholar 

  • Sohaib SA, Moskovic EC. Imaging in vulval cancer. Best Pract Res Clin Obstet Gynaecol. 2003;17(4):543–56.

    Article  PubMed  CAS  Google Scholar 

  • Sohaib SA, Houghton SL, et al. Recurrent endometrial cancer: patterns of recurrent disease and assessment of prognosis. Clin Radiol. 2007;62(1):28–34. discussion 35–6.

    Article  PubMed  CAS  Google Scholar 

  • Staats PN, Clement PB, et al. Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases. Am J Surg Pathol. 2007;31(10):1490–501.

    Article  PubMed  Google Scholar 

  • Strobel K, Dummer R, et al. High-risk melanoma: accuracy of FDG PET/CT with added CT morphologic information for detection of metastases. Radiology. 2007;244(2):566–74.

    Article  PubMed  Google Scholar 

  • Sulak P, Barnhill D, et al. Nonsquamous cancer of the vagina. Gynecol Oncol. 1988;29(3):309–20.

    Article  PubMed  CAS  Google Scholar 

  • Swetter SM, Carroll LA, et al. Positron emission tomography is superior to computed tomography for metastatic detection in melanoma patients. Ann Surg Oncol. 2002;9(7):646–53.

    Article  PubMed  Google Scholar 

  • Takeuchi K, Deguchi M, et al. A case of postirradiation vaginal angiosarcoma treated with recombinant interleukin-2 therapy. Int J Gynecol Cancer. 2005;15(6):1163–5.

    Article  PubMed  CAS  Google Scholar 

  • Tarraza Jr HM, Meltzer SE, et al. Vaginal metastases from renal cell carcinoma: report of four cases and review of the literature. Eur J Gynaecol Oncol. 1998;19(1):14–8.

    PubMed  Google Scholar 

  • Trenhaile TR, Killackey MA. Primary pelvic non-Hodgkin’s lymphoma. Obstet Gynecol. 2001;97(5 Pt 1):717–20.

    Article  PubMed  CAS  Google Scholar 

  • Umeadi UP, Ahmed AS, et al. Vaginal leiomyosarcoma. J Obstet Gynaecol. 2008;28(5):553–4.

    Article  PubMed  CAS  Google Scholar 

  • Vang R, Medeiros LJ, et al. Non-Hodgkin’s lymphoma involving the vagina: a clinicopathologic analysis of 14 patients. Am J Surg Pathol. 2000;24(5):719–25.

    Article  PubMed  CAS  Google Scholar 

  • Yang DM, Kim HC, et al. Leiomyosarcoma of the vagina: MR findings. Clin Imaging. 2009;33(6):482–4.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Diagnostic Imaging, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK

    E. J. O’Donovan, P. Narayanan & Dr. S. A. Sohaib

Authors
  1. E. J. O’Donovan
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  2. P. Narayanan
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  3. Dr. S. A. Sohaib
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Corresponding author

Correspondence to S. A. Sohaib .

Editor information

Editors and Affiliations

  1. Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany

    Bernd Hamm

  2. Department of Radiology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA

    Pablo R. Ros

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© 2013 Springer-Verlag Berlin Heidelberg

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O’Donovan, E.J., Narayanan, P., Sohaib, S.A. (2013). Non-squamous Malignant Disease of the Vagina. In: Hamm, B., Ros, P.R. (eds) Abdominal Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13327-5_200

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  • DOI: https://doi.org/10.1007/978-3-642-13327-5_200

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-13326-8

  • Online ISBN: 978-3-642-13327-5

  • eBook Packages: MedicineReference Module Medicine

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