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Cellular Peptide Hormone Synthesis and Secretory Pathways

  • Book
  • © 2010

Overview

Editors:
  1. Jens F. Rehfeld

    1. Rigshospitalet, Koebenhavns Universitet, Koebenhavn, Denmark

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  2. Jens R. Bundgaard

    1. Rigshospitalet, Koebenhavns Universitet, Koebenhavn OE, Denmark

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    You can also search for this editor in PubMed   Google Scholar

  • illustrates the new endocrine biology, using as examples a broad variety of individual peptide systems
  • written by experts
  • first book to extensively cover the topic
  • Includes supplementary material: sn.pub/extras

Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 50)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
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  2. VIP and PACAP

    • Jan Fahrenkrug
    Pages 1-20

  3. Biosynthesis of Cardiac Natriuretic Peptides

    • Jens Peter Goetze
    Pages 21-44

  4. Chromogranins A and B and Secretogranin II as Prohormones for Regulatory Peptides from the Diffuse Neuroendocrine System

    • Karen B. Helle
    Pages 45-62

  5. Neurotensin and Neuromedin N Are Differentially Processed from a Common Precursor by Prohormone Convertases in Tissues and Cell Lines

    • Patrick Kitabgi
    Pages 63-84

  6. Ghrelin: From Gene to Physiological Function

    • Masayasu Kojima, Kenji Kangawa
    Pages 85-96

  7. Somatostatin and Somatostatin Receptors

    • Ujendra Kumar, Michael Grant
    Pages 97-120

  8. ACTH: Cellular Peptide Hormone Synthesis and Secretory Pathways

    • Adam Stevens, Anne White
    Pages 121-135

  9. Maturation of Secretory Granules

    • Tanja Kögel, Hans-Hermann Gerdes
    Pages 137-184

  10. Cell-Specific Precursor Processing

    • Jens F. Rehfeld, Jens R. Bundgaard
    Pages 185-205

  11. Posttranslational Processing of Progastrin

    • Jens R. Bundgaard, Jens F. Rehfeld
    Pages 207-220

  12. Glucagon and Glucagon-Like Peptides 1 and 2

    • Jens Juul Holst
    Pages 221-234

  13. Back Matter

    Pages 235-239
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Keywords

About this book

The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.

Editors and Affiliations

  • Rigshospitalet, Koebenhavns Universitet, Koebenhavn, Denmark

    Jens F. Rehfeld

  • Rigshospitalet, Koebenhavns Universitet, Koebenhavn OE, Denmark

    Jens R. Bundgaard

Bibliographic Information

  • Book Title: Cellular Peptide Hormone Synthesis and Secretory Pathways

  • Editors: Jens F. Rehfeld, Jens R. Bundgaard

  • Series Title: Results and Problems in Cell Differentiation

  • DOI: https://doi.org/10.1007/978-3-642-11836-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2010

  • Hardcover ISBN: 978-3-642-11834-0Published: 11 March 2010

  • Softcover ISBN: 978-3-642-26276-0Published: 04 May 2012

  • eBook ISBN: 978-3-642-11836-4Published: 10 March 2010

  • Series ISSN: 0080-1844

  • Series E-ISSN: 1861-0412

  • Edition Number: 1

  • Number of Pages: VIII, 239

  • Number of Illustrations: 36 b/w illustrations

  • Topics: Cell Biology, Biochemistry, general

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