Abstract
This chapter will consider the role of planar scintigraphy, SPECT and PET in the imaging of skeletal metastatic disease from a miscellaneous group of malignancies, including lung, thyroid and renal carcinomas; multiple myeloma; and neuroendocrine tumours, and will examine how recent technical advances may enhance their effectiveness in this field. Bone scintigraphy using technetium-labelled diphosphonates has for many years been the mainstay of functional imaging of bony metastases, but this technique is of limited value in evaluating myeloma and aggressive osteolytic metastases and also carries the drawback of relatively poor specificity. Single photon emission computed tomography (SPECT), being a tomographic imaging technique, produces three-dimensional images of tracer distribution from multiplanar images. Its application to bone scintigrams in selected cases can greatly improve accurate anatomical localisation and sensitivity in detection of foci of tracer uptake. SPECT can equally be applied to scintigrams using radiotracers which are specific for particular groups of tumours, including somatostatin analogues for neuroendocrine tumours. The advent of combined SPECT/CT systems in recent years has further enhanced the accuracy of SPECT in all these malignancies. Positron emission tomography (PET) detects pairs of gamma rays emitted indirectly by a positron-emitting radiotracer to achieve a higher spatial resolution than single photon imaging. This high resolution and the ability to cover the entire body in a single scan have made it a highly effective technique for the evaluation of skeletal metastatic disease, and it is now a routine combination with CT as PET/CT can provide combined functional and anatomical imaging data in unprecedented clarity and detail. 18F-FDG PET/CT now forms part of routine staging for many carcinomas, such as non-small cell lung carcinomas, and may obviate the need for routine staging scintigraphy in these patients. As uptake of the commonest PET radiotracer, 18F-FDG is dependent on the increased cellular metabolism of most tumours; it may enable earlier detection of metastatic foci than bone scintigraphy, which relies on detecting osteoblastic activity which may be difficult to visualise in the case of small metastases. Another significant advantage of 18F-FDG PET is that it can detect the soft tissue components of metastases. This is particularly important in aggressive osteolytic metastases, where invasion of adjacent connective tissue and muscle is frequent. The effectiveness of 18F-FDG PET is limited in slow-growing tumour types, but 18F-sodium fluoride, a bone radiotracer which can detect very early osteoblastic changes, already shows promise in this area. Bony metastases from many neuroendocrine tumours can be detected with a high degree of specificity by PET using somatostatin analogues. Other novel and often highly specific radiotracers are under evaluation which will further enhance its diagnostic capability. The true potential of PET in this group of malignancies is gradually unfolding; although studied series of patients remain generally small to date, a more detailed evaluation of its role will require the accrual of considerably more data.
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References
Adams S, Baum R, Rink T et al (1998) Limited value of fluorine-18 fluorodeoxyglucose positron emission tomography for the imaging of neuroendocrine tumors. Eur J Nucl Med 25:79–83
Alexandrakis MG, Kyriakou DS, Passam FH et al (2002) Correlation between the uptake of Tc-99m-sestaMIBI and prognostic factors in patients with multiple myeloma. Clin Lab Haematol 24:155–159
Algra PR, Heimans JJ, Valk J et al (1992) Do metastases in vertebrae begin in the body or the pedicles? Imaging study in 45 patients. AJR Am J Roentgenol 158:1275–1279
Barai S, Bandopadhayaya GP, Malhotra A et al (2004) Does I-131-MIBG underestimate skeletal disease burden in neuroblastoma? J Postgrad Med 50:257–260
Bataille R, Chevalier J, Rossi M et al (1982) Bone scintigraphy in plasma-cell myeloma. A prospective study of 70 patients. Radiology 145:801–804
Baum RP, Hellwig D, Mezzetti M (2004) Position of nuclear medicine modalities in the diagnostic workup of cancer patients: lung cancer. Q J Nucl Med Mol Imaging 48:119–142
Baum RP, Niesen A, Leonhardi J et al (2005) Receptor PET/CT imaging of neuroendocrine tumors using the Ga-68 labelled, high affinity somatostatin analogue DOTA-1-Nal³-octreotide (DOTA-NOC): clinical results in 327 patients. Eur J Nucl Med Mol Imaging 32:S54
Bhargava P, Hanif M, Nash C (2008) Whole-body F-18 sodium fluoride PET-CT in a patient with renal cell carcinoma. Clin Nucl Med 33:894–895
Blau M, Ganatra R, Bender MA (1972) 18F-fluoride for bone imaging. Semin Nucl Med 2:31–37
Boubaker A, BischofDelaloye A (2003) Nuclear medicine procedures and neuroblastoma in childhood. Their value in the diagnosis, staging and assessment of response to therapy. Q J Nucl Med 47:31–40
Bouvier JF, Philip T, Chauvot P et al (1988) Pitfalls and solutions in neuroblastoma diagnosis using radioiodine MIBG: our experience about 50 cases. Prog Clin Biol Res 271:707–720
Brandt-Mainz K, Muller SP, Gorges R et al (2000) The value of fluorine-18 fluorodeoxyglucose PET in patients with medullary thyroid cancer. Eur J Nucl Med 27:490–496
Bredella MA, Steinbach L, Caputo G et al (2005) Value of FDG PET in the assessment of patients with multiple myeloma. AJR Am J Roentgenol 184:1199–1204
Bruzzi JF, Komaki R, Walsh GL et al (2008) Imaging of non-small cell lung cancer of the superior sulcus: part 2: initial staging and assessment of resectability and therapeutic response. Radiographics 28:561–572
Bybel B, Brunken RC, DiFilippo FP et al (2008) SPECT/CT imaging: clinical utility of an emerging technology. Radiographics 28:1097–1113
Cheran SK, Herndon JE, Patz EF (2004) Comparison of whole-body FDG-PET to bone scan for detection of bone metastases in patients with a new diagnosis of lung cancer. Lung Cancer 44:317–325
Cheung N-KV, Kushner BH (2003) Should we replace bone scintigraphy plus CT with MR imaging for staging of neuroblastoma? Radiology 226:286–287
Chiu ML, Kronauge JF, Piwnica-Worms D (1990) Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts. J Nucl Med 31:1646–1653
Cohen R, Campos JM, Salaun C et al (2000) Preoperative calcitonin levels are predictive of tumor size and postoperative calcitonin normalization in medullary thyroid carcinoma. Groupe d’Etudes des Tumeurs a Calcitonine (GETC). J Clin Endocrinol Metab 85:919–922
Conti PS, Durski JM, Bacqai F et al (1999) Imaging of locally recurrent and metastatic thyroid cancer with positron emission tomography. Thyroid 9:797–804
D’Sa S, Abildgaard N, Tighe J et al (2007) Guidelines for the use of imaging in the management of myeloma. Br J Haematol 137:49–63
Dankerl A, Liebisch P, Glatting G et al (2007) Multiple myeloma: molecular imaging with 11C-methionine PET/CT – initial experience. Radiology 242:498–508
de Geus-Oei L-F, Oei H-Y, Hennemann G et al (2002) Sensitivity of 123I whole-body scan and thyroglobulin in the detection of metastases or recurrent differentiated thyroid cancer. Eur J Nucl Med Mol Imaging 29:768–774
de Groot JWB, Links TP, Jager PL et al (2004) Impact of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in patients with biochemical evidence of recurrent or residual medullary thyroid cancer. Ann Surg Oncol 11:786–794
De Maeseneer M, Lenchik L, Everaert H et al (1999) Evaluation of lower back pain with bone scintigraphy and SPECT. Radiographics 19:901–912
Diehl M, Risse JH, Brandt-Mainz K et al (2001) Fluorine-18 fluorodeoxyglucose positron emission tomography in medullary thyroid cancer: results of a multicentre study. Eur J Nucl Med 28:1671–1676
Dowell HM, Losty P, Barnes N et al (2009) Utility of FDG-PET/CT in the follow-up of neuroblastoma which became MIBG-negative. Pediatr Blood Cancer 52(4):552
Durie BGM (2006) The role of anatomic and functional staging in myeloma: description of Durie/Salmon plus staging system. Eur J Cancer 42:1539–1543
Durie BGM, Kyle RA, Belch A et al (2003) Myeloma management guidelines: a consensus report from the Scientific Advisors of the International Myeloma Foundation. Hematol J 4:379–398
Eriksson B, Orlefors H, Oberg K et al (2005) Developments in PET for the detection of endocrine tumors. Best Pract Res Clin Endocrinol Metab 19:311–324
Even-Sapir E, Keidar Z, Sachs J et al (2001) The new technology of combined transmission and emission tomography in evaluation of endocrine neoplasms. J Nucl Med 42:998–991004
Even-Sapir E, Metser U, Flusser G et al (2004) Assessment of malignant skeletal disease: initial experience with 18F-fluoride PET/CT and comparison between 18F-fluoride PET and 18F-fluoride PET/CT. J Nucl Med 45:272–278
Even-Sapir E, Mishani E, Flusser G et al (2007) 18F-Fluoride positron emission tomography and positron emission tomography/computed tomography. Semin Nucl Med 37:462–469
Falini B, Canino S, Sacchi S et al (1988) Immunocytochemical evaluation of the percentage of proliferating cells in pathological bone marrow and peripheral blood samples with the Ki-67 and anti-bromo-deoxyuridine monoclonal antibodies. Br J Haematol 69:311–320
Fogelman I, Cook G, Israel O et al (2005) Positron emission tomography and bone metastases. Semin Nucl Med 35:135–142
Fonti R, Salvatore B, Quarantelli M et al (2008) 18F-FDG PET/CT, 99mTc-MIBI, and MRI in evaluation of patients with multiple myeloma. J Nucl Med 49:195–200
Freudenberg LS, Antoch G, Jentzen W et al (2004) Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer. Eur Radiol 14:2092–2098
Gabriel M, Decristoforo C, Kendler D et al (2007) 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med 48:508–518
Giraudet AL, Vanel D, Leboulleux S et al (2007) Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels. J Clin Endocrinol Metab 92:4185–4190
Grant FD, Fahey FH, Packard AB et al (2008) Skeletal PET with 18F-fluoride: applying new technology to an old tracer. J Nucl Med 49:68–78
Grunwald F, Menzel C, Bender H et al (1997) Comparison of 18FDG-PET with 131iodine and 99mTc-sestamibi scintigraphy in differentiated thyroid cancer. Thyroid 7:327–335
Grunwald F, Kalicke T, Feine U et al (1999) Fluorine-18 fluorodeoxyglucose positron emission tomography in thyroid cancer: results of a multicentre study. Eur J Nucl Med 26:1547–1552
Hafez KS, Novick AC, Campbell SC (1997) Patterns of tumor recurrence and guidelines for followup after nephron sparing surgery for sporadic renal cell carcinoma. J Urol 157:2067–2070
Han K-R, Pantuck AJ, Bui MHT et al (2003) Number of metastatic sites rather than location dictates overall survival of patients with node-negative metastatic renal cell carcinoma. Urology 61:314–319
Hetzel M, Arslandemir C, Konig H-H et al (2003) F-18 NaF PET for detection of bone metastases in lung cancer: accuracy, cost-effectiveness, and impact on patient management. J Bone Miner Res 18:2206–2214
Hung G-U, Tsai C-C, Tsai S-C et al (2005) Comparison of Tc-99m sestamibi and F-18 FDG-PET in the assessment of multiple myeloma. Anticancer Res 25:4737–4741
Iagaru A, Kalinyak JE, McDougall IR (2007) F-18 FDG PET/CT in the management of thyroid cancer. Clin Nucl Med 32:690–695
Ilias I, Pacak K (2005) Diagnosis and management of tumors of the adrenal medulla. Horm Metab Res 37:717–721
Ilias I, Yu J, Carrasquillo JA et al (2003) Superiority of 6-[18F]-fluorodopamine positron emission tomography versus [131I]-metaiodobenzylguanidine scintigraphy in the localization of metastatic pheochromocytoma. J Clin Endocrinol Metab 88:4083–4087
Ito S, Kato K, Ikeda M et al (2007) Comparison of 18F-FDG PET and bone scintigraphy in detection of bone metastases of thyroid cancer. J Nucl Med 48:889–895
Juweid ME, Cheson BD (2006) Positron-emission tomography and assessment of cancer therapy. N Engl J Med 354:496–507
Kaltsas G, Korbonits M, Heintz E et al (2001) Comparison of somatostatin analog and meta-iodobenzylguanidine radionuclides in the diagnosis and localization of advanced neuroendocrine tumors. J Clin Endocrinol Metab 86:895–902
Kang DE, White RL, Zuger JH et al (2004) Clinical use of fluorodeoxyglucose F 18 positron emission tomography for detection of renal cell carcinoma. J Urol 171:1806–1809
Kato T, Tsukamoto E, Nishioka T et al (2000) Early detection of bone marrow involvement in extramedullary plasmacytoma by whole-body F-18 FDG positron emission tomography. Clin Nucl Med 25:870–873
Kollender Y, Bickels J, Price WM et al (2000) Metastatic renal cell carcinoma of bone: indications and technique of surgical intervention. J Urol 164:1505–1508
Koopmans KP, Neels OC, Kema IP et al (2008) Improved staging of patients with carcinoid and islet cell tumors with 18F-dihydroxy-phenyl-alanine and 11C-5-hydroxy-tryptophan positron emission tomography. J Clin Oncol 26:1489–1495
Kosuda S, Kaji T, Yokoyama H et al (1996) Does bone SPECT actually have lower sensitivity for detecting vertebral metastasis than MRI? J Nucl Med 37:975–978
Krausz Y, Israel O (2006) Single-photon emission computed tomography/computed tomography in endocrinology. Semin Nucl Med 36:267–274
Krausz Y, Keidar Z, Kogan I et al (2003) SPECT/CT hybrid imaging with 111In-pentetreotide in assessment of neuroendocrine tumors. Clin Endocrinol (Oxf) 59:565–573
Kulke MH, Mayer RJ (1999) Carcinoid tumors. N Engl J Med 340:858–868
Langsteger W, Heinisch M, Fogelman I (2006) The role of fluorodeoxyglucose, 18F-dihydroxyphenylalanine, 18F-choline, and 18F-fluoride in bone imaging with emphasis on prostate and breast. Semin Nucl Med 36:73–92
Leboulleux S, Dromain C, Vataire AL et al (2008) Prediction and diagnosis of bone metastases in well-differentiated gastro-entero-pancreatic endocrine cancer: a prospective comparison of whole body magnetic resonance imaging and somatostatin receptor scintigraphy. J Clin Endocrinol Metab 93:3021–3028
Levy DA, Slaton JW, Swanson DA et al (1998) Stage specific guidelines for surveillance after radical nephrectomy for local renal cell carcinoma. J Urol 159:1163–1167
Lin JD, Huang MJ, Juang JH et al (1999) Factors related to the survival of papillary and follicular thyroid carcinoma patients with distant metastases. Thyroid 9:1227–1235
Lynn MD, Braunstein EM, Shapiro B (1987) Pheochromocytoma presenting as musculoskeletal pain from bone metastases. Skeletal Radiol 16:552–555
Mamede M, Carrasquillo JA, Chen CC et al (2006) Discordant localization of 2-[18F]-fluoro-2-deoxy-D-glucose in 6-[18F]-fluorodopamine- and [(123)I]-metaiodobenzylguanidine-negative metastatic pheochromocytoma sites. Nucl Med Commun 27:31–36
Meijer WG, van der Veer E, Jager PL et al (2003) Bone metastases in carcinoid tumors: clinical features, imaging characteristics, and markers of bone metabolism. J Nucl Med 44:184–191
Mitchell MS (1992) Chemotherapy in combination with biomodulation: a 5-year experience with cyclophosphamide and interleukin-2. Semin Oncol 19:80–87
Muresan MM, Olivier P, Leclere J et al (2008) Bone metastases from differentiated thyroid carcinoma. Endocr Relat Cancer 15:37–49
Oberg K (1999) Neuroendocrine gastrointestinal tumors – a condensed overview of diagnosis and treatment. Ann Oncol 10(Suppl 2):3–8
Perault C, Schvartz C, Wampach H et al (1997) Thoracic and abdominal SPECT-CT image fusion without external markers in endocrine carcinomas. The Group of Thyroid Tumoral Pathology of Champagne-Ardenne. J Nucl Med 38:1234–1242
Peterson JJ, Kransdorf MJ, O’Connor MI (2003) Diagnosis of occult bone metastases: positron emission tomography. Clin Orthop Relat Res (Suppl 415):120–128
Pezeshk P, Sadow CA, Winalski CS et al (2006) Usefulness of 18F-FDG PET-directed skeletal biopsy for metastatic neoplasm. Acad Radiol 13:1011–1015
Pfannenberg AC, Eschmann SM, Horger M et al (2003) Benefit of anatomical-functional image fusion in the diagnostic work-up of neuroendocrine neoplasms. Eur J Nucl Med Mol Imaging 30:835–843
Robbins RJ, Wan Q, Grewal RK et al (2006) Real-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning. J Clin Endocrinol Metab 91:498–505
Rosen PR, Murphy KG (1984) Bone scintigraphy in the initial staging of patients with renal-cell carcinoma: concise communication. J Nucl Med 25:289–291
Ross EM, Roberts WC (1985) The carcinoid syndrome: comparison of 21 necropsy subjects with carcinoid heart disease to 15 necropsy subjects without carcinoid heart disease. Am J Med 79:339–354
Ruegemer JJ, Hay ID, Bergstralh EJ et al (1988) Distant metastases in differentiated thyroid carcinoma: a multivariate analysis of prognostic variables. J Clin Endocrinol Metab 67:501–508
Ruf J, Lehmkuhl L, Bertram H et al (2004) Impact of SPECT and integrated low-dose CT after radioiodine therapy on the management of patients with thyroid carcinoma. Nucl Med Commun 25:1177–1182
Rufini V, Calcagni ML, Baum RP (2006) Imaging of neuroendocrine tumors. Semin Nucl Med 36:228–247
Sandock DS, Seftel AD, Resnick MI (1995) A new protocol for the followup of renal cell carcinoma based on pathological stage. J Urol 154:28–31
Savelli G, Maffioli L, Maccauro M et al (2001) Bone scintigraphy and the added value of SPECT (single photon emission tomography) in detecting skeletal lesions. Q J Nucl Med 45:27–37
Scarsbrook AF, Ganeshan A, Statham J et al (2007) Anatomic and functional imaging of metastatic carcinoid tumors. Radiographics 27:455–477
Schirrmeister H, Guhlmann A, Elsner K et al (1999) Sensitivity in detecting osseous lesions depends on anatomic localization: planar bone scintigraphy versus 18F PET. J Nucl Med 40:1623–1629
Schirrmeister H, Glatting G, Hetzel J et al (2001a) Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med 42:1800–1804
Schirrmeister H, Buck A, Guhlmann A et al (2001b) Anatomical distribution and sclerotic activity of bone metastases from thyroid cancer assessed with F-18 sodium fluoride positron emission tomography. Thyroid 11:677–683
Schirrmeister H, Bommer M, Buck AK et al (2002) Initial results in the assessment of multiple myeloma using 18F-FDG PET. Eur J Nucl Med Mol Imaging 29:361–366
Schirrmeister H, Arslandemir C, Glatting G et al (2004) Omission of bone scanning according to staging guidelines leads to futile therapy in non-small cell lung cancer. Eur J Nucl Med Mol Imaging 31:964–968
Schlumberger M, Tubiana M, De Vathaire F et al (1986) Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma. J Clin Endocrinol Metab 63:960–967
Schluter B, Bohuslavizki KH, Beyer W et al (2001) Impact of FDG PET on patients with differentiated thyroid cancer who present with elevated thyroglobulin and negative 131I scan. J Nucl Med 42:71–76
Schmidt GP, Schoenberg SO, Schmid R et al (2007) Screening for bone metastases: whole-body MRI using a 32-channel system versus dual-modality PET-CT. Eur Radiol 17:939–949
Shammas A, Degirmenci B, Mountz JM et al (2007) 18F-FDG PET/CT in patients with suspected recurrent or metastatic well-differentiated thyroid cancer. J Nucl Med 48:221–226
Shapiro B, Rufini V, Jarwan A et al (2000) Artifacts, anatomical and physiological variants, and unrelated diseases that might cause false-positive whole-body 131-I scans in patients with thyroid cancer. Semin Nucl Med 30:115–132
Shebani KO, Souba WW, Finkelstein DM et al (1999) Prognosis and survival in patients with gastrointestinal tract carcinoid tumors. Ann Surg 229:815–821
Shulkin BL, Shapiro B (1998) Current concepts on the diagnostic use of MIBG in children. J Nucl Med 39:679–688
Shulkin BL, Wieland DM, Schwaiger M et al (1992) PET scanning with hydroxyephedrine: an approach to the localization of pheochromocytoma. J Nucl Med 33:1125–1131
Shulkin BL, Wieland DM, Baro ME et al (1996) PET hydroxyephedrine imaging of neuroblastoma. J Nucl Med 37:16–21
Shulkin BL, Thompson NW, Shapiro B et al (1999) Pheochromocytomas: imaging with 2-[fluorine-18]fluoro-2-deoxy-D-glucose PET. Radiology 212:35–41
Shulkin BL, Ilias I, Sisson JC et al (2006) Current trends in functional imaging of pheochromocytomas and paragangliomas. Ann N Y Acad Sci 1073:374–382
Sofka CM, Semelka RC, Kelekis NL et al (1999) Magnetic resonance imaging of neuroblastoma using current techniques. Magn Reson Imaging 17:193–198
Stafford SE, Gralow JR, Schubert EK et al (2002) Use of serial FDG PET to measure the response of bone-dominant breast cancer to therapy. Acad Radiol 9:913–921
Staudenherz A, Steiner B, Puig S et al (1999) Is there a diagnostic role for bone scanning of patients with a high pretest probability for metastatic renal cell carcinoma? Cancer 85:153–155
Taggart D, Dubois S, Matthay KK (2008) Radiolabeled metaiodobenzylguanidine for imaging and therapy of neuroblastoma. Q J Nucl Med Mol Imaging 52:403–418
Tenenbaum F, Lumbroso J, Schlumberger M et al (1995) Comparison of radiolabeled octreotide and meta-iodobenzylguanidine (MIBG) scintigraphy in malignant pheochromocytoma. J Nucl Med 36:1–6
Tharp K, Israel O, Hausmann J et al (2004) Impact of 131I-SPECT/CT images obtained with an integrated system in the follow-up of patients with thyroid carcinoma. Eur J Nucl Med Mol Imaging 31:1435–1442
Tickoo SK, Pittas AG, Adler M et al (2000) Bone metastases from thyroid carcinoma: a histopathologic study with clinical correlates. Arch Pathol Lab Med 124:1440–1447
Utsunomiya D, Shiraishi S, Imuta M et al (2006) Added value of SPECT/CT fusion in assessing suspected bone metastasis: comparison with scintigraphy alone and nonfused scintigraphy and CT. Radiology 238:264–271
Vinjamuri M, Craig M, Campbell-Fontaine A et al (2008) Can positron emission tomography be used as a staging tool for small-cell lung cancer? Clin Lung Cancer 9:30–34
Wallace S, Ajani JA, Charnsangavej C et al (1996) Carcinoid tumors: imaging procedures and interventional radiology. World J Surg 20:147–156
Wu HC, Yen RF, Shen YY et al (2002) Comparing whole body 18F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphate bone scan to detect bone metastases in patients with renal cell carcinomas – a preliminary report. J Cancer Res Clin Oncol 128:503–506
Zanotti-Fregonara P, Rubello D, Hindie E (2008) Bone metastases of differentiated thyroid cancer: the importance of early diagnosis and 131I therapy on prognosis. J Nucl Med 49:1902–1903
Zekri J, Ahmed N, Coleman RE et al (2001) The skeletal metastatic complications of renal cell carcinoma. Int J Oncol 19:379–382
Zhu X-x, Chen Y-q, Chen L-h (2004) Value of integrated positron-emission tomography and computed tomography in gross tumor volume delineation for radiotherapy for bone metastasis. Di Yi Jun Yi Da Xue Xue Bao 24:700–702
Zoller M, Kohlfuerst S, Igerc I et al (2007) Combined PET/CT in the follow-up of differentiated thyroid carcinoma: what is the impact of each modality? Eur J Nucl Med Mol Imaging 34:487–495
Zuetenhorst JM, Hoefnageli CA, Boot H et al (2002) Evaluation of (111)In-pentetreotide, (131)I-MIBG and bone scintigraphy in the detection and clinical management of bone metastases in carcinoid disease. Nucl Med Commun 23:735–741
Zuijdwijk MD, Vogel WV, Corstens FHM et al (2008) Utility of fluorodeoxyglucose-PET in patients with differentiated thyroid carcinoma. Nucl Med Commun 29:636–641
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Chua, S.S.C., Gnanasegaran, G., Cook, G.J.R. (2012). Lung, Thyroid, Renal Cancer, Myeloma and Neuroendocrine Cancers: Role of Planar, SPECT and PET in Imaging Bone Metastases. In: Fogelman, I., Gnanasegaran, G., van der Wall, H. (eds) Radionuclide and Hybrid Bone Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02400-9_27
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