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Autism Spectrum Disorders

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Textbook of Clinical Pediatrics

Clinical Vignette

Steven is a 20-month-old boy born at term with no significant medical history except for recurrent ear infections. He had appropriate motor milestones, but his parents became concerned at 14 months because he was not using words and did not respond consistently to his name. He communicates by crying, whining, or leading his mother by the hand to a desired object. Steven does not point or use gestures such as waving or clapping, although will reach his hand toward things he wants. His parents find it difficult to get his attention, and he does not make eye contact readily. His favorite toy is a small car that he carries with him everywhere. He likes to spin the wheels with his finger and watch them out of the corner of his eye. Steven also lines up toys and occasionally flaps his hands.

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References

  • Abrahams BS, Geschwind DH (2008) Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 9:341–355

    Article  PubMed  CAS  Google Scholar 

  • ADDM (2009) Prevalence of autism spectrum disorders – Autism and Developmental Disabilities Monitoring Network, United States, 2006. MMWR Surveill Summ 58:1–20

    Google Scholar 

  • APA (2000) Diagnostic criteria from DSM-IV-TR American Psychiatric Association. Washington, D.C

    Google Scholar 

  • Bailey A, Le Couteur A, Gottesman I et al (1995) Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med 25:63–77

    Article  PubMed  CAS  Google Scholar 

  • Baird G, Simonoff E, Pickles A et al (2006) Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 368:210–215

    Article  PubMed  Google Scholar 

  • Bettelheim B (1967) The empty fortress; infantile autism and the birth of the self. Free Press, New York

    Google Scholar 

  • Brambilla P, Hardan A, di Nemi SU et al (2003) Brain anatomy and development in autism: review of structural MRI studies. Brain Res Bull 61:557–569

    Article  PubMed  Google Scholar 

  • Braunschweig D, Ashwood P, Krakowiak P et al (2008) Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology 29:226–231

    PubMed  CAS  Google Scholar 

  • Buie T, Fuchs GJ 3rd, Furuta GT et al (2010) Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics 125(Suppl 1):S19–S29

    Article  PubMed  Google Scholar 

  • Chakrabarti S, Fombonne E (2001) Pervasive developmental disorders in preschool children. JAMA 285:3093–3099

    Article  PubMed  CAS  Google Scholar 

  • Chez MG, Chang M, Krasne V et al (2006) Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy Behav 8:267–271

    Article  PubMed  Google Scholar 

  • Courchesne E, Carper R, Akshoomoff N (2003) Evidence of brain overgrowth in the first year of life in autism. JAMA 290:337–344

    Article  PubMed  Google Scholar 

  • Croen LA, Najjar DV, Fireman B et al (2007) Maternal and paternal age and risk of autism spectrum disorders. Arch Pediatr Adolesc Med 161:334–340

    Article  PubMed  Google Scholar 

  • Ellefsen A, Kampmann H, Billstedt E et al (2007) Autism in the Faroe Islands: an epidemiological study. J Autism Dev Disord 37:437–444

    Article  PubMed  Google Scholar 

  • Enstrom A, Krakowiak P, Onore C et al (2009) Increased IgG4 levels in children with autism disorder. Brain Behav Immun 23:389–395

    Article  PubMed  CAS  Google Scholar 

  • Filipek PA, Juranek J, Nguyen MT et al (2004) Relative carnitine deficiency in autism. J Autism Dev Disord 34:615–623

    Article  PubMed  Google Scholar 

  • Fombonne E (2002) Epidemiological trends in rates of autism. Mol Psychiatry 7(Suppl 2):S4–S6

    Article  PubMed  Google Scholar 

  • Fombonne E (2009) Epidemiology of pervasive developmental disorders. Pediatr Res 65:591–598

    Article  PubMed  Google Scholar 

  • Fombonne E, Zakarian R, Bennett A et al (2006) Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations. Pediatrics 118:e139–e150

    Article  PubMed  Google Scholar 

  • Goldberg WA, Osann K, Filipek PA et al (2003) Language and other regression: assessment and timing. J Autism Dev Disord 33:607–616

    Article  PubMed  Google Scholar 

  • Hansen RL, Ozonoff S, Krakowiak P et al (2008) Regression in autism: prevalence and associated factors in the CHARGE Study. Ambul Pediatr 8:25–31

    Article  PubMed  Google Scholar 

  • Hertz-Picciotto I, Croen LA, Hansen R et al (2006) The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect 114:1119–1125

    Article  PubMed  Google Scholar 

  • Hertz-Picciotto I, Delwiche L (2009) The rise in autism and the role of age at diagnosis. Epidemiology 20:84–90

    Article  PubMed  Google Scholar 

  • Heuer L, Ashwood P, Schauer J et al (2008) Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res 1:275–283

    Article  PubMed  Google Scholar 

  • Howlin P (2005) The effectiveness of interventions for children with autism. J Neural Transm 69(Suppl):101–119

    Google Scholar 

  • Ibrahim SH, Voigt RG, Katusic SK et al (2009) Incidence of gastrointestinal symptoms in children with autism: a population-based study. Pediatrics 124:680–686

    Article  PubMed  Google Scholar 

  • Icasiano F, Hewson P, Machet P et al (2004) Childhood autism spectrum disorder in the Barwon region: a community based study. J Paediatr Child Health 40:696–701

    Article  PubMed  CAS  Google Scholar 

  • INSERM (2002) Expertise collective. Troubles mentaux. Dépistage et prévention chez l’enfant et l’adolescent

    Google Scholar 

  • Johnson CP, Myers SM (2007) Identification and evaluation of children with autism spectrum disorders. Pediatrics 120:1183–1215

    Article  PubMed  Google Scholar 

  • Kawamura Y, Takahashi O, Ishii T (2008) Reevaluating the incidence of pervasive developmental disorders: impact of elevated rates of detection through implementation of an integrated system of screening in Toyota, Japan. Psychiatry Clin Neurosci 62:152–159

    Article  PubMed  Google Scholar 

  • Krakowiak P, Goodlin-Jones B, Hertz-Picciotto I et al (2008) Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study. J Sleep Res 17:197–206

    Article  PubMed  Google Scholar 

  • Lainhart JE, Bigler ED, Bocian M et al (2006) Head circumference and height in autism: a study by the collaborative program of excellence in autism. Am J Med Genet A 140:2257–2274

    PubMed  Google Scholar 

  • Lord C, Risi S, Lambrecht L et al (2000) The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 30:205–223

    Article  PubMed  CAS  Google Scholar 

  • Lord C, Risi S, Pickles A (2004) Trajectory of language development in autistic spectrum disorders. In: Rice M, Warren SF (eds) Developmental language disorders: from phenotypes to etiologies. Erlbaum, Mahwah, pp 7–30

    Google Scholar 

  • Miller DT, Adam MP, Aradhya S et al (2010) Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet 86:749–764

    Article  PubMed  CAS  Google Scholar 

  • Montiel-Nava C, Pena JA (2008) Epidemiological findings of pervasive developmental disorders in a Venezuelan study. Autism 12:191–202

    Article  PubMed  Google Scholar 

  • Muhle R, Trentacoste SV, Rapin I (2004) The genetics of autism. Pediatrics 113:e472–e486

    Article  PubMed  Google Scholar 

  • Offit PA, Coffin SE (2003) Communicating science to the public: MMR vaccine and autism. Vaccine 22:1–6

    Article  PubMed  Google Scholar 

  • Parker SK, Schwartz B, Todd J et al (2004) Thimerosal-containing vaccines and autistic spectrum disorder: a critical review of published original data. Pediatrics 114:793–804

    Article  PubMed  Google Scholar 

  • Phillips L, Appleton RE (2004) Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment. Dev Med Child Neurol 46:771–775

    Article  PubMed  Google Scholar 

  • Premack A, Woodruff G (1978) Does the chimpanzee have a theory of mind? Behav Brain Sci 4:515–526

    Article  Google Scholar 

  • Redcay E, Courchesne E (2005) When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biol Psychiatry 58:1–9

    Article  PubMed  Google Scholar 

  • Reichenberg A, Gross R, Weiser M et al (2006) Advancing paternal age and autism. Arch Gen Psychiatry 63:1026–1032

    Article  PubMed  Google Scholar 

  • Rutter M, Le Couteur A, Lord C (2003) ADI-R: The autism diagnostic interview-Revised. Western Psychological Services, Los Angeles

    Google Scholar 

  • Spence MA (2001) The genetics of autism. Curr Opin Pediatr 13:561–565

    Article  PubMed  CAS  Google Scholar 

  • Spence SJ, Schneider MT (2009) The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatr Res 65:599–606

    Article  PubMed  Google Scholar 

  • Tuchman R, Rapin I (2002) Epilepsy in autism. Lancet Neurol 1:352–358

    Article  PubMed  Google Scholar 

  • Tuman JP, Roth-Johnson D, Baker DL et al (2008) Autism and special education policy in Mexico. Glob Health Governance 2:1–22

    Google Scholar 

  • World Health Organization (2007) International statistical classification of diseases and related health problems 10th revision version for 2007. WHO, Geneva

    Google Scholar 

  • Wing L, Potter D (2002) The epidemiology of autistic spectrum disorders: is the prevalence rising? Ment Retard Dev Disabil Res Rev 8:151–161

    Article  PubMed  Google Scholar 

  • Wing L, Yeates SR, Brierley LM et al (1976) The prevalence of early childhood autism: comparison of administrative and epidemiological studies. Psychol Med 6:89–100

    Article  PubMed  CAS  Google Scholar 

  • Wong VC, Hui SL (2008) Epidemiological study of autism spectrum disorder in China. J Child Neurol 23:67–72

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, UC Davis Children’s Hospital and UC Davis MIND Institute, 2825 50th Street, 95817, Sacramento, CA, USA

    Dr. Kathleen Angkustsiri M.D. & Dr. Robin L. Hansen M.D.

Authors
  1. Dr. Kathleen Angkustsiri M.D.
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  2. Dr. Robin L. Hansen M.D.
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Corresponding author

Correspondence to Kathleen Angkustsiri M.D. .

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Editors and Affiliations

  1. Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

    Abdelaziz Y. Elzouki (Professor of Pediatrics) (Professor of Pediatrics)

  2. National Center of Allergy, Asthma & Immunology (NCAAI), Riyadh, Saudi Arabia

    Harb A. Harfi (Director) (Director)

  3. Consultant Pediatric Gastroenterology & Hepatology, Islamic Hospital, Amman, Jordan

    Hisham M. Nazer

  4. Seattle Children's Hospital University of Washington, School of Medicine, Seattle, WA, USA

    F. Bruder Stapleton (Professor and Chair Department of Pediatrics) (Professor and Chair Department of Pediatrics)

  5. Alpert Medical School of Brown University, Woman and Infants Hospital, Providence, RI, USA

    William Oh (Professor of Pediatrics) (Professor of Pediatrics)

  6. University of Alabama, Birmingham, AL, USA

    Richard J. Whitley (Professor of Pediatrics) (Professor of Pediatrics)

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© 2012 Springer-Verlag Berlin Heidelberg

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Angkustsiri, K., Hansen, R.L. (2012). Autism Spectrum Disorders. In: Elzouki, A.Y., Harfi, H.A., Nazer, H.M., Stapleton, F.B., Oh, W., Whitley, R.J. (eds) Textbook of Clinical Pediatrics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02202-9_47

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  • DOI: https://doi.org/10.1007/978-3-642-02202-9_47

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02201-2

  • Online ISBN: 978-3-642-02202-9

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