Skip to main content

Lymphome und lymphoproliferative Erkrankungen der Lunge

  • Chapter
  • First Online:
Pathologie

Zusammenfassung

In diesem Kapitel werden die organtypischen Befunde bei primärer Diagnose von lymphoroliferativen Erkrankungen und Neoplasien in der Lunge behandelt. Eine besondere Bedeutung besitzt das extranodale Marginalzonenlymphom vom MALT Typ der Lunge, das von Vorstadien und entzündlichen Manifestationen differenziert werden muss, das großzellige B-Zell Lymphom das entweder primär als Progressionsstadium des MALT Lymphoms interpretiert wird oder sekundär als metastatischer Befall auftreten kann, und die eigenartige EBV-assoziierte lymphomatoide Granulomatose, die besonders häufig mit einem primären Befall der Lungen beginnt. Auch wenn diese Erkrankungen in der WHO nur zum Teil als separate Entitäten gelistet sind, besitzen sie so viele organotypische Eigenschaften, dass eine separate Besprechung gerechtfertigt ist und bei der schwierigen Diagnose hilft.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 389.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  1. Coffin CM, Hornick JL, Fletcher CD (2007) Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol 31:509–520

    Article  Google Scholar 

  2. Ferreri AJ, Dognini GP, Campo E, Willemze R, Seymour JF, Bairey O, Martelli M, De Renz AO, Doglioni C, Montalban C, Tedeschi A, Pavlovsky A, Morgan S, Uziel L, Ferracci M, Ascani S, Gianelli U, Patriarca C, Facchetti F, Dalla Libera A, Pertoldi B, Horvath B, Szomor A, Zucca E, Cavalli F, Ponzoni M, International Extranodal Lymphoma Study Group (IELSG) (2007) Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions. Haematologica 92:486–492

    Article  Google Scholar 

  3. Guinee D Jr, Jaffe E, Kingma D, Fishback N, Wallberg K, Krishnan J, Frizzera G, Travis W, Koss M (1994) Pulmonary lymphomatoid granulomatosis. Evidence for a proliferation of Epstein-Barr virus infected B-lymphocytes with a prominent T-cell component and vasculitis. Am J Surg Pathol 18:753–764

    Article  Google Scholar 

  4. Haque AK, Myers JL, Hudnall SD, Gelman BB, Lloyd RV, Payne D, Borucki M (1998) Pulmonary lymphomatoid granulomatosis in acquired immunodeficiency syndrome: lesions with Epstein-Barr virus infection. Mod Pathol 11:347–356

    CAS  PubMed  Google Scholar 

  5. Hare SS, Souza CA, Bain G, Seely JM, Gomes MM, Quigley M et al (2012) The radiological spectrum of pulmonary lymphoproliferative disease. Br J Radiol 85:848–864

    Article  CAS  Google Scholar 

  6. Ilowite NT, Fligner CL, Ochs HD, Brichacek B, Harada S, Haas JE, Purtilo DT, Wedgwood RJ (1986) Pulmonary angiitis with atypical lymphoreticular infiltrates in Wiskott-Aldrich syndrome: possible relationship of lymphomatoid granulomatosis and EBV infection. Clin Immunol Immunopathol 41:479–484

    Article  CAS  Google Scholar 

  7. Ishii Y, Tomita N, Takasaki H, Ogusa E, Hattori Y, Matsuura S, Matsumoto C, Takemura S, Kuwabara H, Ishigatsubo Y (2012) Clinical features of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Hematol Oncol 30:186–189

    Article  Google Scholar 

  8. Katzenstein AL, Peiper SC (1990) Detection of Epstein-Barr virus genomes in lymphomatoid granulomatosis: analysis of 29 cases by the polymerase chain reaction technique. Mod Pathol 3:435–441

    CAS  PubMed  Google Scholar 

  9. Khalil MO, Morton LM, Devesa SS, Check DP, Curtis RE, Weisenburger DD, Dores GM (2014) Incidence of marginal zone lymphoma in the United States, 2001-2009 with a focus on primary anatomic site. Br J Haematol 165:67–77

    Article  Google Scholar 

  10. Kim JH, Lee SH, Park J, Kim HY, Lee SI, Park JO, Kim K, Kim WS, Jung CW, Park YS, Im YH, Kang WK, Lee MH, Park K, Han JH, Ko YH (2004) Primary pulmonary non-Hodgkin’s lymphoma. Jpn J Clin Oncol 34:510–514

    Article  Google Scholar 

  11. Koss MN, Hochholzer L, Nichols PW, Wehunt WD, Lazarus AA (1983) Primary non-Hodgkin’s lymphoma and pseudolymphoma of lung: a study of 161 patients. Hum Pathol 14:1024–1038

    Article  CAS  Google Scholar 

  12. Kurtin PJ, Myers JL, Adlakha H, Strickler JG, Lohse C, Pankratz VS, Inwards DJ (2001) Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. Am J Surg Pathol 25:997–1008

    Article  CAS  Google Scholar 

  13. McNiff JM, Cooper D, Howe G, Crotty PL, Tallini G, Crouch J, Eisen RN (1996) Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder. Arch Dermatol 132:1464–1470

    Article  CAS  Google Scholar 

  14. Mitchell A, Meunier C, Ouellette D, Colby T (2006) Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with initial presentation in the pleura. Chest 129:791–794

    Article  Google Scholar 

  15. Mittal K, Neri A, Feiner H, Schinella R, Alfonso F (1990) Lymphomatoid granulomatosis in the acquired immunodeficiency syndrome. Evidence of Epstein-Barr virus infection and B-cell clonal selection without myc rearrangement. Cancer 65:1345–1349

    Article  CAS  Google Scholar 

  16. Myers JL, Kurtin PJ, Katzenstein AL, Tazelaar HD, Colby TV, Strickler JG, Lloyd RV, Isaacson PG (1995) Lymphomatoid granulomatosis. Evidence of immunophenotypic diversity and relationship to Epstein-Barr virus infection. Am J Surg Pathol 19:1300–1312

    Article  CAS  Google Scholar 

  17. Nicholson AG (2004) Marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type. In: Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC (Hrsg) WHO classification of tumours, pathology and genetics, tumours of the lung, pleura, thymus and heart, 3. Aufl. IARC, Lyon, S 88–90

    Google Scholar 

  18. Nicholson AG, Jaffe ES, Guinee D (2015) Lymphohistiocytic tumours. In: Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG (Hrsg) WHO classification of tumours of the lung, pleura, thymus and heart, 4. Aufl. IARC, Lyon, S 134

    Google Scholar 

  19. Nicholson AG, Wotherspoon AC, Diss TC, Butcher DN, Sheppard MN, Isaacson PG, Corrin B (1995) Pulmonary B-cell non-Hodgkin’s lymphomas. The value of immunohistochemistry and gene analysis in diagnosis. Histopathology 26:395–403

    Article  CAS  Google Scholar 

  20. Oh SY, Kim WS, Kim JS, Kim SJ, Lee S, Lee DH, Won JH, Hwang IG, Kim MK, Lee SI, Chae YS, Yang DH, Kang HJ, Choi CW, Park J, Kim HJ, Kwon JH, Lee HS, Lee GW, Eom HS, Kwak JY, Lee WS, Suh C, Kim HJ (2010) Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study. Int J Hematol 92:510–517

    Article  Google Scholar 

  21. Remstein ED, Kurtin PJ, Einerson RR, Paternoster SF, Dewald GW (2004) Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including aneuploidy and translocations involving API2 and MALT1 and IGH and MALT1. Leukemia 18:156–160

    Article  CAS  Google Scholar 

  22. Streubel B, Simonitsch-Klupp I, Mullauer L, Lamprecht A, Huber D, Siebert R, Stolte M, Trautinger F, Lukas J, Puspok A, Formanek M, Assanasen T, Muller-Hermelink HK, Cerroni L, Raderer M, Chott A (2004) Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites. Leukemia 18:1722–1726

    Article  CAS  Google Scholar 

  23. Yoon RG, Kim MY, Song JW, Chae EJ, Choi CM, Jang S (2013) Primary endobronchial marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue: CT findings in 7 patients. Korean J Radiol 14:366–374

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Peter Möller .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Möller, P., Ott, G. (2019). Lymphome und lymphoproliferative Erkrankungen der Lunge. In: Müller-Hermelink, H., Kreipe, H. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85184-4_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-85184-4_34

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85183-7

  • Online ISBN: 978-3-540-85184-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics