Abstract
Behçet’s disease (BD) is a relapsing multisystemic disorder with obliterative vasculitis affecting both arteries and veins including vasculopathy of capillaries. In 1937, Hulusi Behçet described oral aphthous ulcers, genital ulcers, and hypopyon uveitis as a triad.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aktulga E, Altac M, Muftuoglu A et al (1980) A double blind study of colchicine in Behçet’s disease. Haematologica 65:399–402
Atmaca LS (1989) Fundus changes associated with Behçet’s disease. Graefes Arch Clin Exp Ophthalmol 227:340–344
Behçet H (1937) Über rezidivierende Aphthose, durch ein Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 105:1152–1157
Behçet’s disease: guide to diagnosis of Behçet’s di-sease. Behçet’s Disease Research Committee of Japan (1974) Jpn J Ophthalmol 18:291–294
BenEzra D, Atmaca LS (1999) Behçet’s disease. In: BenEzra D (ed) Ocular inflammation. Basic and clinical concepts. Martin Dunitz, London, pp 313–345
BenEzra D, Maftzir G, Kalichman I et al (1993) Serum levels of interleukin-2 receptor in ocular Behçet’s disease. Am J Ophthalmol 115:26–30
BenEzra D, Maftzir G, Barak V (1997) Blood serum interleukin-1 receptor antagonist in pars planitis and ocular Behçet disease. Am J Ophthalmol 123:593–598
Bodaghi B, Gendron G, Wechsler B et al (2007) Efficacy of interferon alpha in the treatment of refractory and sight threatening uveitis: a retrospective monocentric study of 45 patients. Br J Ophthalmol 91:335–339
Sugi-Ikai N, Nakazawa M, Nakamura S et al (1998) Increased frequencies of interleukin-2- and interferon-gamma-producing T cells in patients with active Behçet’s disease. Invest Ophthalmol Vis Sci 39:996–1004
Criteria for diagnosis of Behçet’s disease. International Study Group for Behçet’s Disease (1990) Lancet 335:1078–1080
Deuter CM, Kotter I, Wallace GR et al (2008) Behçet’s disease: ocular effects and treatment. Prog Retin Eye Res 27:111–136
Dilsen N (2003) The importance of the manifestations besides the ones included in international criteria for Behçet’s disease. Adv Exp Med Biol 528:105–108
Dilsen N, Konice M, Aral O, Ocal L, Inanc M, Gul A (1993) Comparative study of the skin pathergy test with blunt and sharp needles in Behçet’s disease: confirmed specificity but decreased sensitivity with sharp needles. Ann Rheum Dis 52:823–825
Dilsen N, Konice M, Aral O (1986) Why Behçet’s disease should be accepted as a seronegative arthritis. In: Lehner T, Barnes CG (eds) Recent advances in Behçet’s disease. Royal Society of Medicine Services, London, pp 281–284
Fortune F, Walker J, Lehner T (1990) The expression of gamma delta T cell receptor and the prevalence of primed, activated and IgA-bound T cells in Behçet’s syndrome. Clin Exp Immunol 82:326–332
Hamuryudan V, Ozyazgan Y, Hizli N et al (1997) Azathioprine in Behçet’s syndrome: effects on long-term prognosis. Arthritis Rheum 40:769–774
Ishikawa S, Miyata M, Fujiwara N (1979) Experimental muco-enterogenital syndrome in pedigreed miniature swine (toxicological study). Excerpta Med Int Ser 467:53–57
Kaneko S, Suzuki N, Yamashita N et al (1997) Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behçet’s disease (BD) in Japan. Clin Exp Immunol 108:204–212
Kari JA, Shah V, Dillon MJ (2001) Behçet’s disease in UK children: clinical features and treatment including thalidomide. Rheumatology (Oxford) 40:933–938
Kontogiannis V, Powell RJ (2000) Behçet’s disease. Postgrad Med J 76:629–637
Kotake S, Higashi K, Yoshikawa K et al (1999) Central nervous system symptoms in patients with Behçet disease receiving cyclosporine therapy. Ophthalmology 106:586–589
Kotter I, Durk H, Saal J et al (1996) Therapy of Behçet’s disease. Ger J Ophthalmol 5:92–97
Kotter I, Koch S, Vonthein R et al (2005) Cytokines, cytokine antagonists and soluble adhesion molecules in patients with ocular Behçet’s disease treated with human recombinant interferon-alpha2a. Results of an open study and review of the literature. Clin Exp Rheumatol 23:S20–S26
Kotter I, Zierhut M, Eckstein A et al (2003) Human recombinant interferon-alpha2a (rhIFN alpha2a) for the treatment of Behçet’s disease with sight-threatening retinal vasculitis. Adv Exp Med Biol 528:521–523
Krause L, Turnbull JR, Torun N et al (2003) Interferon alfa-2a in the treatment of ocular Adamantiades-Behçet’s disease. Adv Exp Med Biol 528:511–519
Masuda K, Inaba G, Mizushima Y et al (1975) A nationwide survey of Behçet’s disease in Japan. Jpn J Ophthalmol 19:278–285
Masuda K, Nakajima A, Urayama A et al (1989) Double-masked trial of cyclosporin versus colchicine and long-term open study of cyclosporin in Behçet’s disease. Lancet 1:1093–1096
Matsumura N, Mizushima Y (1975) Leucocyte movement and colchicine treatment in Behçet’s disease. Lancet 2:813
Mishima S, Masuda K, Izawa Y et al (1979) The eighth Frederick H. Verhoeff Lecture. presented by Saiichi Mishima. Behçet’s disease in Japan: ophthalmologic aspects. Trans Am Ophthalmol Soc 77:225–279
Mizushima Y, Matsuda T, Hoshi K et al (1988) Induction of Behçet’s disease symptoms after dental treatment and streptococcal antigen skin test. J Rheumatol 15:1029–1030
Mumcu G, Eragun T, Inanc N et al (2004) Oral health is impaired in Behçet’s disease and is associated with disease severity. Rheumatology (Oxford) 43(8):1028–1033
Mushtaq B, Saeed T, Situnayake RD et al (2007) Adalimumab for sight-threatening uveitis in Behçet’s disease. Eye 21:824–825
Naganuma M, Funakoshi S, Sakuraba A et al (2004) Granulocytapheresis is useful as an alternative therapy in patients with steroid-refractory or -dependent ulcerative colitis. Inflamm Bowel Dis 10:251–257
Nakae K, Masaki F, Hashimoto T et al (1993) Recent epidemiological features of Behçet’s disease in Japan. In: Wechsler B, Godeau P (eds) Behçet’s disease. Excerpta Medica, Amsterdam, pp 153–158
Nakamura S, Sugita M, Tanaka S et al (1992) Enhanced production of in vitro tumor necrosis factor-alpha from monocytes in Behçet’s disease. Nippon Ganka Gakkai Zasshi 96:1282–1285
Namba K, Sonoda KH, Kitamei H et al (2006) Granulocytapheresis in patients with refractory ocular Behçet’s disease. J Clin Apher 21:121–128
Niwa Y, Miyake S, Sakane T et al (1982) Auto-oxidative damage in Behçet’s disease – endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils. Clin Exp Immunol 49:247–255
Nussenblatt RB, Palestine AG (1986) Cyclosporine: immunology, pharmacology and therapeutic uses. Surv Ophthalmol 31:159–169
Ohguro N, Yamanaka E, Otori Y et al (2006) Repeated intravitreal triamcinolone injections in Behçet disease that is resistant to conventional therapy: one-year results. Am J Ophthalmol 141:218–220
Ohno S, Nakamura S, Hori S et al (2004) Efficacy, safety, and pharmacokinetics of multiple administration of infliximab in Behçet’s disease with refractory uveoretinitis. J Rheumatol 31:1362–1368
Ohno S, Ohguchi M, Hirose S et al (1982) Close association of HLA-Bw51 with Behçet’s disease. Arch Ophthalmol 100:1455–1458
Pervin K, Childerstone A, Shinnick T et al (1993) T cell epitope expression of mycobacterial and homologous human 65-kilodalton heat shock protein peptides in short term cell lines from patients with Behçet’s disease. J Immunol 151:2273–2282
Saylan T, Mat C, Fresko I, Melikoglu M (1999) Behçet’s disease in the Middle East. Clin Dermatol 17:209–223
Stuebiger N, Koetter I, Zierhut M (2000) Complete regression of retinal neovascularization after therapy with interferon alfa in Behçet’s disease. Br J Ophthalmol 84:1437–1438
Suzuki Y, Hoshi K, Matsuda T et al (1992) Increased peripheral blood gamma delta+ T cells and natural killer cells in Behçet’s disease. J Rheumatol 19:588–592
Takeno M, Kariyone A, Yamashita N et al (1995) Excessive function of peripheral blood neutrophils from patients with Behçet’s disease and from HLA-B51 transgenic mice. Arthritis Rheum 38:426–433
The International study group for Behçet’s disease (1992) Evaluation of diagnostic (‘classification’) criteria in Behçet’s disease-towards internationally agreed criteria. Br J Rheumatol 31:299–308
Tugal-Tutkun I, Guney-Tefekli E, Urgancioglu M (2006) Results of interferon-alfa therapy in patients with Behçet uveitis. Graefes Arch Clin Exp Ophthalmol 244:1692–1695
Tugal-Tutkun I, Onal S, Altan-Yaycioglu R et al (2004) Uveitis in Behçet disease: an analysis of 880 patients. Am J Ophthalmol 138:373–380
Tugal-Tutkun I, Onal S, Altan-Yaycioglu R et al (2006) Neovascularization of the optic disc in Behçet’s disease. Jpn J Ophthalmol 50:256–265
Yazici H, Pazarli H, Barnes CG et al (1990) A controlled trial of azathioprine in Behçet’s syndrome. N Engl J Med 322:281–285
Yazici H, Tüzün Y, Pazarli H et al (1984) Influence of age of onset and patient’s sex on the prevalence and severity of manifestations of Behçet’s syndrome. Ann Rheum Dis 43:783–789
Yazici H, Yurdakul S, Hamuryudan V (1998) Behçet’s syndrome. In: Klippel JH, Dieppe PA (eds) Rheumatology, vol 2, 2nd edn. Mosby, London, pp 7.26.1–7.26.6
Yazici H, Yurdakul S, Hamuryudan V (1999) Behçet’s syndrome. Curr Opin Rheumatol 11:53–57
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
1 Electronic Supplementary Material
Below is the link to the electronic supplementary material.
Case Report 64
Behcet’s disease in an Indian patient (PPT 2762 kb)
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Ohno, S., Namba, K., Takemoto, Y. (2016). Behçet’s Disease. In: Zierhut, M., Pavesio, C., Ohno, S., Orefice, F., Rao, N. (eds) Intraocular Inflammation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75387-2_66
Download citation
DOI: https://doi.org/10.1007/978-3-540-75387-2_66
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-75385-8
Online ISBN: 978-3-540-75387-2
eBook Packages: MedicineMedicine (R0)