Abstract
Onchocerciasis, or river blindness, is a major tropical parasitic infection caused by the filarial worm, Onchocerca volvulus. The first manifestation of infection is usually intense pruritus, and subsequently a wide variety of skin and eye changes develop, with ocular damage being the most serious complication.
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References
Abiose A (1998) Onchocercal eye disease and the impact of Mectizan treatment. Ann Trop Med Parasitol 92(Suppl 1):S11–S22
Abiose A, Jones BR, Cousens SN et al (1993) Reduction in incidence of optic nerve disease with annual ivermectin to control onchocerciasis. Lancet 341(8838):130–134
African Programme for Onchocerciasis Research (APOC) (2005) Final communique of the 11th session of the Joint Action Forum (JAF) of APOC, Paris, France. APOC, Ouagadougou (Burkina Faso), pp 6–9, Ref Type: Generic
Aziz MA, Diallo S, Diop IM et al (1982) Efficacy and tolerance of ivermectin in human onchocerciasis. Lancet 2(8291):171–173
Basanez MG, Pion SD, Churcher TS et al (2006) River blindness: a success story under threat? PLoS Med 3:e371
Bird AC, Anderson J, Fuglsang H (1976) Morphology of posterior segment lesions of the eye in patients with onchocerciasis. Br J Ophthalmol 60:2–20
Bird AC, el-Sheikh H, Anderson J et al (1979) Visual loss during oral diethylcarbamazine treatment for onchocerciasis. Lancet 2(8132):46
Bird AC, el-Sheikh H, Anderson J et al (1980) Changes in visual function and in the posterior segment of the eye during treatment of onchocerciasis with diethylcarbamazine citrate. Br J Ophthalmol 64:191–200
Boatin BA, Toe L, Alley ES et al (1998) Diagnostics in onchocerciasis: future challenges. Ann Trop Med Parasitol 92(Suppl 1):S41–S45
Brattig NW, Bazzocchi C, Kirschning et al (2004) The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4. J Immunol 173:437–445
Braun G, McKechnie GW (1995) Molecular and immunological characterization of hr44, a human ocular component immunologically crossreactive antigen Ov39 of Onchocerca volvulus. J Exp Med 182:1121–1132
Braun G, McKechnie NM, Connor V et al (1991) Immunological crossreactivity between a cloned antigen of Onchocerca volvulus and a component of the retinal pigment epithelium. J Exp Med 174:169–177
Centers for Disease Control and Prevention (CDC) (2013) Progress toward elimination of onchocerciasis in the Americas – 1993–2012. MMWR Morb Mortal Wkly Rep 62:405
Chippaux JP, Boussinesq M, Fobi G et al (1999) Effect of repeated ivermectin treatments on ocular onchocerciasis: evaluation after six to eight doses. Ophthalmic Epidemiol 6:229–246
Choyce DP (1971) Impacted microfilaria in the lens capsule. Br J Ophthalmol 55:861
Cousens SN, Yahaya H, Murdoch I et al (1997) Risk factors for optic nerve disease in communities mesoendemic for savannah onchocerciasis, Kaduna State, Nigeria. Trop Med Int Health 2:89–98
Duke BOL (1966) Onchocerca-Simulium complexes: III – the survival of Simulium damnosum after high intakes of microfilariae of incompatible strains of Onchocerca volvulus and the survival of the parasites in the fly. Ann Trop Med Parasitol 6:495–500
Enk CD, Anteby I, Abramson N et al (2003) Onchocerciasis among Ethiopian immigrants in Israel. Isr Med Assoc J 5:485–488
Evans TG (1995) Socioeconomic consequences of blinding onchocerciasis in west Africa. Bull World Health Organ 73:495–506
Hise AG, Daehnel K, Gillette-Ferguson I et al (2007) Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM. J Immunol 178:1068–1076
Hissette J (1938) Ocular onchocerciasis. Am J Trop Med Hyg 18(Suppl):58–90
Hoerauf A (2008) Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis. Curr Opin Infect Dis 21:673
Hoerauf A, Mand S, Adjei O et al (2001) Depletion of wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment. Lancet 357:1415
Hoerauf A, Specht S, Büttner M et al (2008) Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study. Med Microbiol Immunol 197:295
Hoerauf A, Volkmann L, Hamelmann C et al (2000) Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis. Lancet 355(9211):​1242–1243
Kaifi JT, Diaconu E, Pearlman E (2001) Distinct roles for PECAM-1, ICAM-1, and VCAM-1 in recruitment of neutrophils and eosinophils to the cornea in ocular onchocerciasis (river blindness). J Immunol 166:​6795–6801
Kennedy MH, Bertocchi I, Hopkins AD et al (2002) The effect of 5 years of annual treatment with ivermectin (Mectizan) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic. Ann Trop Med Parasitol 96:​297–307
Kirkwood B, Smith P, Marshall T et al (1983) Relationships between mortality, visual acuity and microfilarial load in the area of the Onchocerciasis Control Programme. Trans R Soc Trop Med Hyg 77:862–868
McKechnie NM, Braun G, Connor V et al (1993) Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis. Invest Ophthalmol Vis Sci 34:2888–2902
McKechnie NM, Gurr W, Yamada H et al (2002) Antigenic mimicry: onchocerca volvulus antigen-specific T cells and ocular inflammation. Invest Ophthalmol Vis Sci 43:411–418
Murdoch ME (1992) The skin and the immune response in onchocerciasis. Trop Dr 22(Suppl 1):44–55
Murdoch I, Abiose A, Babalola O et al (1994) Ivermectin and onchocercal optic neuritis: short-term effects. Eye 8:456–461
Murdoch ME, Asuzu MC, Hagan M et al (2002) Onchocerciasis: the clinical and epidemiological burden of skin disease in Africa. Ann Trop Med Parasitol 96:283–296
Murdoch ME, Hay RJ, Mackenzie CD et al (1993) A clinical classification and grading system of the cutaneous changes in onchocerciasis. Br J Dermatol 129:260–269
Murray CJ, Vos T, Lozano R et al (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2197–2223
Onchocerciasis and its control. Report of a WHO Expert Committee on Onchocerciasis Control (1995) World Health Organ Tech Rep Ser 852:1–104
Park J, Dickerson TJ, Janda KD (2008) Major sperm protein as a diagnostic antigen for onchocerciasis. Bioorg Med Chem 16:7206–7209
Remme JHF (2004) The global burden of onchocerciasis in 1990. World Health Organization, Geneva, http://www.who.int/healthinfo/statistics/bod_onchocercaisis1990.pdf
Ridley H (1945) Ocular onchocerciasis. Including an investigation in the Gold Coast. Br J Ophthalmol Monograph Supplement 295:1–58
Saint AA, Blackwell NM, Hall LR et al (2002) The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Science 295(5561):​1892–1895
Semba RD, Murphy RP, Newland HS et al (1990) Longitudinal study of lesions of the posterior segment in onchocerciasis. Ophthalmology 97:1334–1341
Taylor HR (1989) Ivermectin treatment of onchocerciasis. Aust N Z J Ophthalmol 17:435–438
Tekle AH, Elhassan E, Isiyaku S et al (2012) Impact of long-term treatment of onchocerciasis with ivermectin in Kaduna State, Nigeria: first evidence of the potential for elimination in the operational area of the African Programme for Onchocerciasis Control. Parasit Vectors 5:28. doi:10.1186/1756-3305-5-28
Thylefors B (1976) Intra-ocular pressure in onchocerciasis. Some preliminary results of a field evaluation. Bull World Health Organ 54:113–114
Tonjum AM, Thylefors B (1978) Aspects of corneal changes in onchocerciasis. Br J Ophthalmol 62:​458–461
Turner JD, Tendongfor N, Esum M et al (2010) Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial. PLoS Negl Trop Dis 4:e660
Yang YF, Cousens S, Murdoch IE et al (2001) Intraocular pressure and gonioscopic findings in rural communities mesoendemic and nonendemic for onchoceriasis, Kaduna State, Nigeria. Eye 15:​756–759
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Murdoch, M.E., Murdoch, I.E. (2016). Onchocerciasis. In: Zierhut, M., Pavesio, C., Ohno, S., Orefice, F., Rao, N. (eds) Intraocular Inflammation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75387-2_134
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DOI: https://doi.org/10.1007/978-3-540-75387-2_134
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