Abstract
Animal studies have shown that local injection of botulinum toxins improves pain behavior via blocking the release of pain transmitters and modulators. In human, carefully designed studies comparing the effect of local injection of botulinum toxins with placebo (salt water) have demonstrated efficacy of toxin injection in relieving the pain of chronic osteoarthritis, local pain of tennis elbow, chronic pain after knee surgery and knee pain related to tightness of lateral thigh muscles.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Neogi T. Structural correlates of pain in osteoarthritis. Clin Exp Rheumatol. 2017, September–October; 35 Suppl 107(5):75–78. Epub 2017 Sep 29.
Dunlop DD, Manheim LM, Song J, Chang RW. Arthritis prevalence and activity limitations in older adults. Arthritis Rheum. 2001;44:212–21.
Malhowald ML, Singh JA, Dykstra D. Long term effects of intra-articular injection of botulinum toxin A for refractory joint pain. Neurotox Res. 2006;9(2–3):179–88.
Arendt-Nielsen L, Jiang GL, DeGryse R, et al. Intra-articular Onabotulinum toxin A in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain. Scand J Rheumatol. 2017;46:303–16.
Nguyen C, Rannou F. The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review. Expert Opin Drug Saf. 2017;16(8):897–902.
Luk JKH, Tsang RCC, Leung HB. Lateral Epicondylalgia: midlife crisis of a tendon. Honk Kong Med J. 2014;20:145–51.
Centers for Disease Control and Prevention. Number of all-listed procedures for discharges from short-stay hospitals, by procedure category and age: United States, 2010. Atlanta: Centers for Disease Control and Prevention; 2010.
Beswick AD, Wylde V, Gooberman-Hill R, et al. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients. BMJ Open. 2012;2:e000435.
Beswick AD, Wylde V, Gooberman-Hill R. Interventions for the prediction and management of chronic postsurgical pain after total knee replacement: systematic review of randomised controlled trials. BMJ Open. 2015 May 12;5(5):e007387. https://doi.org/10.1136/bmjopen-2014-007387.
Singh JA, Mahowald ML, Noorbaloochi S. Intraarticular botulinum toxin A for refractory painful total knee arthroplasty: a randomized controlled trial. J Rheumatol. 2010;37(11):2377–86.
Pal S, Besier TF, Draper CE, Fredericson M. Patellar tilt correlates with vastus lateralis: vastus medialis activation ratio in maltracking patellofemoral pain patients. J Orthop Res. 2012;30(6):927–33. https://doi.org/10.1002/jor.22008. Epub 2011 Nov 15
Singer BJ, Silbert PL, Song S, et al. Treatment of refractory anterior knee pain using botulinum toxin type A (Dysport) injection to the distal vastus lateralis muscle: a randomised placebo controlled crossover trial. J Sports Med. 2011;45(8):640–5.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Jabbari, B. (2018). Botulinum Toxin Therapy in Joint and Bone Problems – Emerging Literature Radiates Hope. In: Botulinum Toxin Treatment . Springer, Cham. https://doi.org/10.1007/978-3-319-99945-6_10
Download citation
DOI: https://doi.org/10.1007/978-3-319-99945-6_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-99944-9
Online ISBN: 978-3-319-99945-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)