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Felty’s Syndrome

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Rare Rheumatic Diseases of Immunologic Dysregulation

Part of the book series: Rare Rheumatic Diseases ((RRD))

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Abstract

Felty’s syndrome (FS) is a rare rheumatic disorder characterized by inflammatory arthritis, neutropenia, and splenomegaly. Pathogenesis is still not completely understood, but genetics are believed to play a role with HLA-DRB1*04 homozygosity highly associated in patient’s presenting with FS. Patients with FS typically have high titer rheumatoid factor and anti-CCP autoantibody. T cell chronic large granular lymphocytic leukemia should be considered in the evaluation of patients with rheumatoid arthritis presenting with hematologic abnormalities. Therapy with methotrexate has been considered gold standard, but recent clinical research is examining the role for rituximab (Rituxan).

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Authors and Affiliations

  1. Division of Rheumatology, Allergy and Immunology, Department of Medicine, Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    Jennifer Medlin & Rumey C. Ishizawar

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  1. Jennifer Medlin
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  2. Rumey C. Ishizawar
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Correspondence to Jennifer Medlin .

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  1. Department of Medicine, Duke University School of Medicine, Durham, NC, USA

    Teresa Kathleen Tarrant

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Medlin, J., Ishizawar, R.C. (2019). Felty’s Syndrome. In: Tarrant, T. (eds) Rare Rheumatic Diseases of Immunologic Dysregulation. Rare Rheumatic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-99139-9_8

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  • DOI: https://doi.org/10.1007/978-3-319-99139-9_8

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