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Local Anesthetics

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Abstract

Local anesthetics block nerve conduction via blockade of voltage-gated sodium channels. The physiochemical properties of the individual drugs lead to variability in individual drug potency, onset, and duration. Systemic toxicity can occur via drug overdose, intravenous dosing, or impaired drug elimination. Clinical signs of toxicity can be manifested via the central nervous system and may progress to the cardiovascular system. Treatment of local anesthetic systemic toxicity (LAST) is directed at supportive treatment and administration of lipid emulsion.

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Author information

Authors and Affiliations

  1. Department of Surgical Sciences, University of Wisconsin School of Veterinary Medicine, Madison, WI, USA

    Carrie Schroeder

  2. Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Kristopher Schroeder

Authors
  1. Carrie Schroeder
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  2. Kristopher Schroeder
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Corresponding author

Correspondence to Kristopher Schroeder .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA

    Alaa Abd-Elsayed

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Schroeder, C., Schroeder, K. (2019). Local Anesthetics. In: Abd-Elsayed, A. (eds) Pain. Springer, Cham. https://doi.org/10.1007/978-3-319-99124-5_216

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  • DOI: https://doi.org/10.1007/978-3-319-99124-5_216

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-99123-8

  • Online ISBN: 978-3-319-99124-5

  • eBook Packages: MedicineMedicine (R0)

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