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Kinetic Modeling of Radiotracers

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Radiopharmaceutical Chemistry

Abstract

Positron emission tomography (PET) is a powerful tool for the noninvasive measurement of biological parameters. Because of its inherently quantitative nature, PET can be used to measure radioactivity concentrations in the blood and various tissues over time. Using the proper tracer and tracer kinetic model, this information can be used to determine parameters such as blood flow, receptor availability, and substrate metabolism. In this chapter, we will first discuss the basic concept of quantitative PET measurements. Then, we will describe compartment models for blood flow, irreversible kinetics, and receptor-ligand kinetics in more detail. The use of these compartment models for the computation of voxel-wise maps of functional parameters requires the linearization of the compartment models, which is addressed in the context of both irreversible and reversible models. Finally, further simplifications that do not require dynamic scanning are briefly described. Although this chapter is by no means exhaustive, it aims to provide an introduction to the use of tracer kinetic models to derive functional parameters from PET data.

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Author information

Authors and Affiliations

  1. Department of Surgical Sciences – Radiology & Nuclear Medicine, Uppsala University and Medical Physics, Uppsala University Hospital, Uppsala, Sweden

    Mark Lubberink

  2. Wallenberg Centre for Molecular and Translational Medicine and the Institute of Neuroscience and Physiology, University of Gothenburg, Gotenburg, Sweden

    Kerstin Heurling

Authors
  1. Mark Lubberink
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  2. Kerstin Heurling
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Correspondence to Mark Lubberink .

Editor information

Editors and Affiliations

  1. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Jason S. Lewis

  2. Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

    Albert D. Windhorst

  3. Department of Chemistry, Hunter College, City University of New York, New York, NY, USA

    Brian M. Zeglis

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Lubberink, M., Heurling, K. (2019). Kinetic Modeling of Radiotracers. In: Lewis, J., Windhorst, A., Zeglis, B. (eds) Radiopharmaceutical Chemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-98947-1_28

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  • DOI: https://doi.org/10.1007/978-3-319-98947-1_28

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-98946-4

  • Online ISBN: 978-3-319-98947-1

  • eBook Packages: MedicineMedicine (R0)

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