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Chronic Hepatitis C

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Liver Disease

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Abstract

Hepatitis C (HCV) is a common viral infection of the liver. It affects approximately 1.6% of the US population. Screening in the appropriate populations is essential as signs and symptoms of the disease are generally absent. In addition, there are multiple new treatments for HCV which are extremely effective and very well tolerated. In this chapter, we describe a case of HCV in an asymptomatic patient. We discuss screening strategies, evaluation of the infection, and treatment options and outcomes.

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Further Reading

  1. Afdhal N, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection (ION-1 study). N Engl J Med. 2014;370:1889–98.

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  2. American Association for the Study of Liver Disease/Infectious Disease Society of America (AASLD-IDSA). HCV guidance: recommendations for testing, managing, and treating hepatitis C. http://hcvguidelines.org. Accessed 9 Nov 2017.

  3. CDC guidelines on HCV screening. http://www.cdc.gov/nchhstp/newsroom/HepTestingRecsPressRelease2012.html. Accessed 23 May 2012.

  4. Feld JJ, et al. Sofosbuvir and velpatasvir for HCV genotype 1,2,4,5, and 6 infection. N Engl J Med. 2015;373:2599–607.

    Article  CAS  Google Scholar 

  5. Kowdley KV, et al. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis (ION-3 study). N Engl J Med. 2014;370:1879–88.

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  6. Rockstroh JK, et al. Efficacy and safety of grazoprevir and elbasvir in patients with hepatitis C virus and HIV co-infection (C-EDGE Co-Infection): a non-randomised, open label trial. The Lancet HIV. 2015;2:e319–27.

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  7. Zeuzem S, et al. ENDURANCE-1: A phase 3 evaluation of the efficacy and safety of 8- versus 12-week treatment with glecaprevir/Pibrentasvir in HCV genotype 1 infected patients with or without HIV-1 co-infection and without cirrhosis. Presented as a poster at AASLD 2016, Boston MA.

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Author information

Authors and Affiliations

  1. Hepatology, Digestive Health Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA

    Stanley Martin Cohen

  2. Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Stanley Martin Cohen

Authors
  1. Stanley Martin Cohen
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Correspondence to Stanley Martin Cohen .

Editor information

Editors and Affiliations

  1. Case Western Reserve University, School of Medicine, University Hospitals of Cleveland, Cleveland, OH, USA

    Stanley Martin Cohen

  2. Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, USA

    Perica Davitkov

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Cohen, S.M. (2019). Chronic Hepatitis C. In: Cohen, S., Davitkov, P. (eds) Liver Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-98506-0_7

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  • DOI: https://doi.org/10.1007/978-3-319-98506-0_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-98505-3

  • Online ISBN: 978-3-319-98506-0

  • eBook Packages: MedicineMedicine (R0)

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