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Treatment of Drug-Induced Parkinsonism

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Therapy of Movement Disorders

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Drug-induced parkinsonism (DIP) is a common movement disorder characterized by the rapid development of a most commonly symmetrical and akinetic-rigid syndrome weeks after initiation of a causative medication that resolves completely within months after withdrawal. Besides neuroleptics, the list of medications known to induce parkinsonism is long and includes, among many others, calcium channel blockers, antidepressants, and antiepileptics. Most have in common to alter dopaminergic transmission, more specifically D2 receptor-mediated motor modulation in the striatum. DIP and Parkinson’s disease (PD) may be virtually indistinguishable, yet some particular features may help to separate them. However, in a quarter of suspected DIP cases, the offending agent seems to have unmasked, rather than induced, a preexisting neurodegenerative condition. There is no specific treatment for DIP besides stopping the incriminated medication which, in the majority of patients, is curative.

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Author information

Authors and Affiliations

  1. Movement Disorders Unit, Department of Neurology, Geneva University Hospitals, Genève, Switzerland

    Pierre R. Burkhard MD

Authors
  1. Pierre R. Burkhard MD
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Correspondence to Pierre R. Burkhard MD .

Editor information

Editors and Affiliations

  1. The Frederick Henry Prince Distinguished, Professor in Neurology, Department of Neurology, University of Maryland, Baltimore, Baltimore, MD, USA

    Stephen G. Reich

  2. Vance Lanier Chair of Neurology, Professor, Department of Neurology, Director, Jean and Paul Amos Parkinson’s Disease and Movement Disorder Program, Emory University, Atlanta, GA, USA

    Stewart A. Factor

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Burkhard, P.R. (2019). Treatment of Drug-Induced Parkinsonism. In: Reich, S., Factor, S. (eds) Therapy of Movement Disorders. Current Clinical Neurology. Humana, Cham. https://doi.org/10.1007/978-3-319-97897-0_66

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  • DOI: https://doi.org/10.1007/978-3-319-97897-0_66

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  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-319-97896-3

  • Online ISBN: 978-3-319-97897-0

  • eBook Packages: MedicineMedicine (R0)

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