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Pediatrics Cancers

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Absolute Clinical Radiation Oncology Review

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Abstract

This chapter discusses the general management of patients with various pediatric solid tumors, with special focus on principles that guide radiotherapy management. Several key components of pediatric cancer care are discussed.

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References

  1. Friedman DL, Whitton J, Leisenring W, et al. Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2010;102:1083–95.

    Article  Google Scholar 

  2. Schultz KR, Pullen DJ, Sather HN, et al. Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children’s Cancer Group (CCG). Blood. 2007;109:926–35.

    Article  CAS  Google Scholar 

  3. Anghelescu DL, Faughnan LG, Jeha S, et al. Neuropathic pain during treatment for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011;57:1147–53.

    Article  Google Scholar 

  4. Martinez-Monge R, Gomez-Iturriaga A, Cambeiro M, et al. Phase I-II trial of perioperative high-dose-rate brachytherapy in oral cavity and oropharyngeal cancer. Brachytherapy. 2009;8:26–33.

    Article  Google Scholar 

  5. Cook B DT: Wikibooks Radiation Oncology. https://en.wikibooks.org/wiki/Radiation_Oncology. Accessed April 2018.

  6. Edge S, Byrd D, Compton C, et al. AJCC cancer staging manual. New York: Springer; 2010.

    Google Scholar 

  7. Hansen E, Roach M. Handbook of evidence-based radiation oncology. 2nd ed. New York: Springer; 2010.

    Book  Google Scholar 

  8. Hristov B, Lin SH, Christodouleas JP. Radiation oncology – a question based review. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2014.

    Google Scholar 

  9. Arndt CA, Stoner JA, Hawkins DS, et al. Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803. J Clin Oncol. 2009;27:5182–8.

    Article  CAS  Google Scholar 

  10. Crist W, Gehan EA, Ragab AH, et al. The third intergroup rhabdomyosarcoma study. J Clin Oncol. 1995;13:610–30.

    Article  CAS  Google Scholar 

  11. Crist WM, Anderson JR, Meza JL, et al. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol. 2001;19:3091–102.

    Article  CAS  Google Scholar 

  12. Maurer HM, Beltangady M, Gehan EA, et al. The intergroup rhabdomyosarcoma study-I. A final report. Cancer. 1988;61:209–20.

    Article  CAS  Google Scholar 

  13. Maurer HM, Gehan EA, Beltangady M, et al. The intergroup rhabdomyosarcoma study-II. Cancer. 1993;71:1904–22.

    Article  CAS  Google Scholar 

  14. Nesbit ME Jr, Gehan EA, Burgert EO Jr, et al. Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the first intergroup study. J Clin Oncol. 1990;8:1664–74.

    Article  Google Scholar 

  15. Malempati S, Hawkins DS. Rhabdomyosarcoma: review of the Children’s Oncology Group (COG) Soft-Tissue Sarcoma Committee experience and rationale for current COG studies. Pediatr Blood Cancer. 2012;59:5–10.

    Article  Google Scholar 

  16. Burgert EO Jr, Nesbit ME, Garnsey LA, et al. Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: intergroup study IESS-II. J Clin Oncol. 1990;8:1514–24.

    Article  Google Scholar 

  17. Donaldson SS, Torrey M, Link MP, et al. A multidisciplinary study investigating radiotherapy in Ewing’s sarcoma: end results of POG #8346. Pediatric Oncology Group. Int J Radiat Oncol Biol Phys. 1998;42:125–35.

    Article  CAS  Google Scholar 

  18. Grier HE, Krailo MD, Tarbell NJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003;348:694–701.

    Article  CAS  Google Scholar 

  19. Heyn RM, Holland R, Newton WA Jr, et al. The role of combined chemotherapy in the treatment of rhabdomyosarcoma in children. Cancer. 1974;34:2128–42.

    Article  CAS  Google Scholar 

  20. Schuck A, Ahrens S, Paulussen M, et al. Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials. Int J Radiat Oncol Biol Phys. 2003;55:168–77.

    Article  Google Scholar 

  21. Schuck A, Rube C, Konemann S, et al. Postoperative radiotherapy in the treatment of Ewing tumors: influence of the interval between surgery and radiotherapy. Strahlenther Onkol. 2002;178:25–31.

    Article  Google Scholar 

  22. D’Angio GJ, Breslow N, Beckwith JB, et al. Treatment of Wilms’ tumor. Results of the Third National Wilms’ tumor study. Cancer. 1989;64:349–60.

    Article  Google Scholar 

  23. D’Angio GJ, Evans A, Breslow N, et al. The treatment of Wilms’ tumor: results of the Second National Wilms’ tumor study. Cancer. 1981;47:2302–11.

    Article  Google Scholar 

  24. D’Angio GJ, Evans AE, Breslow N, et al. The treatment of Wilms’ tumor: results of the National Wilms’ tumor study. Cancer. 1976;38:633–46.

    Article  Google Scholar 

  25. Green DM, Breslow NE, Beckwith JB, et al. Comparison between single-dose and divided-dose administration of dactinomycin and doxorubicin for patients with Wilms’ tumor: a report from the National Wilms’ tumor study group. J Clin Oncol. 1998;16:237–45.

    Article  CAS  Google Scholar 

  26. Grundy PE, Breslow NE, Li S, et al. Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol. 2005;23:7312–21.

    Article  CAS  Google Scholar 

  27. de Kraker J, Lemerle J, Voute PA, et al. Wilms’ tumor with pulmonary metastases at diagnosis: the significance of primary chemotherapy. International Society of Pediatric Oncology Nephroblastoma Trial and Study Committee. J Clin Oncol. 1990;8:1187–90.

    Article  Google Scholar 

  28. Ruteshouser EC, Huff V. Familial Wilms tumor. Am J Med Genet C Semin Med Genet. 2004;129c:29–34.

    Article  Google Scholar 

  29. Breslow N, Olshan A, Beckwith JB, et al. Epidemiology of Wilms tumor. Med Pediatr Oncol. 1993;21:172–81.

    Article  CAS  Google Scholar 

  30. Castleberry RP, Kun LE, Shuster JJ, et al. Radiotherapy improves the outlook for patients older than 1 year with Pediatric Oncology Group stage C neuroblastoma. J Clin Oncol. 1991;9:789–95.

    Article  CAS  Google Scholar 

  31. London WB, Castleberry RP, Matthay KK, et al. Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children’s Oncology Group. J Clin Oncol. 2005;23:6459–65.

    Article  CAS  Google Scholar 

  32. Matthay KK, Villablanca JG, Seeger RC, et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children’s Cancer Group. N Engl J Med. 1999;341:1165–73.

    Article  CAS  Google Scholar 

  33. Matthay KK, Yanik G, Messina J, et al. Phase II study on the effect of disease sites, age, and prior therapy on response to iodine-131-metaiodobenzylguanidine therapy in refractory neuroblastoma. J Clin Oncol. 2007;25:1054–60.

    Article  CAS  Google Scholar 

  34. Nitschke R, Smith EI, Shochat S, et al. Localized neuroblastoma treated by surgery: a Pediatric Oncology Group Study. J Clin Oncol. 1988;6:1271–9.

    Article  CAS  Google Scholar 

  35. Strother D, van Hoff J, Rao PV, et al. Event-free survival of children with biologically favourable neuroblastoma based on the degree of initial tumour resection: results from the Pediatric Oncology Group. Eur J Cancer. 1997;33:2121–5.

    Article  CAS  Google Scholar 

  36. Shields CL, Shields JA, Needle M, et al. Combined chemoreduction and adjuvant treatment for intraocular retinoblastoma. Ophthalmology. 1997;104:2101–11.

    Article  CAS  Google Scholar 

  37. Chantada G, Doz F, Antoneli CB, et al. A proposal for an international retinoblastoma staging system. Pediatr Blood Cancer. 2006;47:801–5.

    Article  Google Scholar 

  38. Wong FL, Boice JD Jr, Abramson DH, et al. Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA. 1997;278:1262–7.

    Article  CAS  Google Scholar 

  39. Duffner PK, Horowitz ME, Krischer JP, et al. The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric Oncology Group experience. Neuro-Oncology. 1999;1:152–61.

    Article  CAS  Google Scholar 

  40. Packer RJ, Goldwein J, Nicholson HS, et al. Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: a Children’s Cancer Group Study. J Clin Oncol. 1999;17:2127–36.

    Article  CAS  Google Scholar 

  41. Rutkowski S, Bode U, Deinlein F, et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005;352:978–86.

    Article  CAS  Google Scholar 

  42. Thomas PR, Deutsch M, Kepner JL, et al. Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation. J Clin Oncol. 2000;18:3004–11.

    Article  CAS  Google Scholar 

  43. Zeltzer PM, Boyett JM, Finlay JL, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children’s Cancer Group 921 randomized phase III study. J Clin Oncol. 1999;17:832–45.

    Article  CAS  Google Scholar 

  44. Brandes AA, Franceschi E, Tosoni A, et al. Long-term results of a prospective study on the treatment of medulloblastoma in adults. Cancer. 2007;110:2035–41.

    Article  Google Scholar 

  45. Koshy M, Rich S, Merchant TE, et al. Post-operative radiation improves survival in children younger than 3 years with intracranial ependymoma. J Neuro-Oncol. 2011;105:583–90.

    Article  Google Scholar 

  46. Merchant TE, Li C, Xiong X, et al. Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study. Lancet Oncol. 2009;10:258–66.

    Article  Google Scholar 

  47. Rogers L, Pueschel J, Spetzler R, et al. Is gross-total resection sufficient treatment for posterior fossa ependymomas? J Neurosurg. 2005;102:629–36.

    Article  Google Scholar 

  48. Calaminus G, Kortmann R, Worch J, et al. SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease. Neuro-Oncology. 2013;15:788–96.

    Article  CAS  Google Scholar 

  49. Rogers SJ, Mosleh-Shirazi MA, Saran FH. Radiotherapy of localised intracranial germinoma: time to sever historical ties? Lancet Oncol. 2005;6:509–19.

    Article  CAS  Google Scholar 

  50. Balmaceda C, Heller G, Rosenblum M, et al. Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study. J Clin Oncol. 1996;14:2908–15.

    Article  CAS  Google Scholar 

  51. Stripp DC, Maity A, Janss AJ, et al. Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults. Int J Radiat Oncol Biol Phys. 2004;58:714–20.

    Article  Google Scholar 

  52. Regine WF, Kramer S. Pediatric craniopharyngiomas: long term results of combined treatment with surgery and radiation. Int J Radiat Oncol Biol Phys. 1992;24:611–7.

    Article  CAS  Google Scholar 

  53. Winkfield KM, Linsenmeier C, Yock TI, et al. Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73:716–21.

    Article  Google Scholar 

  54. Cohen KJ, Heideman RL, Zhou T, et al. Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children’s Oncology Group. Neuro-Oncology. 2011;13:410–6.

    Article  Google Scholar 

  55. Edwards MS, Wara WM, Urtasun RC, et al. Hyperfractionated radiation therapy for brain-stem glioma: a phase I-II trial. J Neurosurg. 1989;70:691–700.

    Article  CAS  Google Scholar 

  56. Greenberg ML, Fisher PG, Freeman C, et al. Etoposide, vincristine, and cyclosporin A with standard-dose radiation therapy in newly diagnosed diffuse intrinsic brainstem gliomas: a pediatric oncology group phase I study. Pediatr Blood Cancer. 2005;45:644–8.

    Article  Google Scholar 

  57. Jalali R, Raut N, Arora B, et al. Prospective evaluation of radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma. Int J Radiat Oncol Biol Phys. 2010;77:113–8.

    Article  CAS  Google Scholar 

  58. Janssens GO, Jansen MH, Lauwers SJ, et al. Hypofractionation vs conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis. Int J Radiat Oncol Biol Phys. 2013;85:315–20.

    Article  Google Scholar 

  59. Skowronska-Gardas A. A literature review of the recent radiotherapy clinical trials in pediatric brain tumors. Rev Recent Clin Trials. 2009;4:42–55.

    Article  Google Scholar 

  60. Janssens GO, Gidding CE, Van Lindert EJ, et al. The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a pilot study. Int J Radiat Oncol Biol Phys. 2009;73:722–6.

    Article  Google Scholar 

  61. Negretti L, Bouchireb K, Levy-Piedbois C, et al. Hypofractionated radiotherapy in the treatment of diffuse intrinsic pontine glioma in children: a single institution’s experience. J Neuro-Oncol. 2011;104:773–7.

    Article  Google Scholar 

  62. Wu G, Broniscer A, McEachron TA, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012;44:251–3.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Penn State Cancer Institute, Hershey, PA, USA

    Nicholas G. Zaorsky

  2. Mayo Clinic, Jacksonville, FL, USA

    Daniel M. Trifiletti

  3. University of Pennsylvania, Philadelphia, PA, USA

    Christine E. Hill-Kayser

Authors
  1. Nicholas G. Zaorsky
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  2. Daniel M. Trifiletti
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  3. Christine E. Hill-Kayser
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Corresponding author

Correspondence to Nicholas G. Zaorsky .

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Editors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL, USA

    Daniel M. Trifiletti

  2. Department of Radiation Oncology, Penn State Cancer Institute, Hershey, PA, USA

    Nicholas G. Zaorsky

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Zaorsky, N.G., Trifiletti, D.M., Hill-Kayser, C.E. (2019). Pediatrics Cancers. In: Trifiletti, D., Zaorsky, N. (eds) Absolute Clinical Radiation Oncology Review. Springer, Cham. https://doi.org/10.1007/978-3-319-96809-4_2

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  • DOI: https://doi.org/10.1007/978-3-319-96809-4_2

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  • Online ISBN: 978-3-319-96809-4

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