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Estrogens and Male Osteoporosis

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Male Osteoporosis

Part of the book series: Trends in Andrology and Sexual Medicine ((TASM))

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Abstract

Estrogens play an important role on bone health in men since they are needed for the achievement of peak bone mass at puberty and prevent bone loss in adulthood. Recent advancements in the comprehension of estrogen action on bone have pointed out on the importance of relative estrogen deficiency in men with low serum testosterone as a major determinant of osteoporosis in hypogonadal men. The recent use of mass spectrometry for sex steroid measurements also in the setting of clinical laboratories will allow the monitoring of both hypogonadism and testosterone therapy having as endpoint the normalization of serum estradiol too in addition to serum testosterone.

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Abbreviations

BMD:

Bone mineral density

CHH:

Congenital hypogonadotropic hypogonadism

EMAS:

European Male Aging Study

ER:

Estrogen receptor

GH:

Growth hormone

GPER30:

Transmembrane G protein-coupled receptor GPR30

IGF-1:

Insulin growth factor-1

MrOS:

Osteoporotic Fractures in Men Study

PTH:

Parathyroid hormone

RANK:

Receptor activator of nuclear factor kappa-B

RANKL:

Receptor activator of nuclear factor kappa-B ligand

RBS:

Rancho Bernardo Study

SERMs:

Selective estrogen receptors modulators

TRT:

Testosterone replacement treatment

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Authors and Affiliations

  1. Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

    Vincenzo Rochira

  2. Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy

    Vincenzo Rochira & Bruno Madeo

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  1. Vincenzo Rochira
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  1. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

    Alberto Ferlin

  2. Department of Movement Human and Health Sciences, Foro Italico University of Rome, Rome, Italy

    Silvia Migliaccio

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Rochira, V., Madeo, B. (2020). Estrogens and Male Osteoporosis. In: Ferlin, A., Migliaccio, S. (eds) Male Osteoporosis. Trends in Andrology and Sexual Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-96376-1_6

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