Abstract
Gastroesophageal reflux symptoms are relatively common, seen in almost two-thirds of people in the United States. Gastroesophageal reflux disease, or GERD, is the presence of esophageal damage accompanying reflux symptoms. Typical symptoms include heartburn and regurgitation. Atypical symptoms include chronic sore throat, cough, hoarseness, laryngitis, asthma, dysphagia, excessive salivation, globus, and dental erosions. GERD can be characterized as erosive or nonerosive esophagitis based upon the presence or absence of mucosal breaks seen on endoscopy. Erosive esophagitis is more likely to lead to complications including stricture, ulcers, and metaplasia, Barrett’s esophagus, and adenocarcinoma in the distal esophagus, as a result of full-thickness mucosal injury.
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References
Chandrasoma P, Wijetunge S, Demeester SR, Hagen J, Demeester TR. The histologic squamo-oxyntic gap: an accurate and reproducible diagnostic marker of gastroesophageal reflux disease. Am J Surg Pathol. 2010;34(11):1574–81. https://doi.org/10.1097/PAS.0b013e3181f06990.
Dent J, Dodds WJ, Friedman RH, Sekiguchi T, Hogan WJ, Arndorfer RC, Petrie DJ. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest. 1980;65(2):256–67. https://doi.org/10.1172/jci109667.
el-Serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology. 1997;113(3):755–60.
Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology. 2009;136(2):376–86. https://doi.org/10.1053/j.gastro.2008.12.015.
Genta RM, Spechler SJ, Kielhorn AF. The Los Angeles and Savary-Miller systems for grading esophagitis: utilization and correlation with histology. Dis Esophagus. 2011;24(1):10–7. https://doi.org/10.1111/j.1442-2050.2010.01092.x.
Karam SM. Lineage commitment and maturation of epithelial cells in the gut. Front Biosci. 1999;4:D286–98.
Munoz JV, Herreros B, Sanchiz V, Amoros C, Hernandez V, Pascual I, et al. Dental and periodontal lesions in patients with gastro-oesophageal reflux disease. Dig Liver Dis. 2003;35(7):461–7.
Schneider JH, Kuper MA, Konigsrainer A, Brucher BL. Transient lower esophageal sphincter relaxation and esophageal motor response. J Surg Res. 2010;159(2):714–9. https://doi.org/10.1016/j.jss.2009.02.021.
Solcia E, Villani L, Luinetti O, Trespi E, Strada E, Tinelli C, Fiocca R. Altered intercellular glycoconjugates and dilated intercellular spaces of esophageal epithelium in reflux disease. Virchows Arch. 2000;436(3):207–16.
Tobey NA, Hosseini SS, Argote CM, Dobrucali AM, Awayda MS, Orlando RC. Dilated intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium. Am J Gastroenterol. 2004;99(1):13–22.
Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101(8):1900–20.; quiz 1943. https://doi.org/10.1111/j.1572-0241.2006.00630.x.
Wyman JB, Dent J, Heddle R, Dodds WJ, Toouli J, Downton J. Control of belching by the lower oesophageal sphincter. Gut. 1990;31(6):639–46.
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Shada, A. (2019). Evaluation of GERD: Symptoms and Disease Classification. In: Grams, J., Perry, K., Tavakkoli, A. (eds) The SAGES Manual of Foregut Surgery . Springer, Cham. https://doi.org/10.1007/978-3-319-96122-4_6
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DOI: https://doi.org/10.1007/978-3-319-96122-4_6
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