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Uncovering the Importance of Selenium in Muscle Disease

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Selenium

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

A connection between selenium bioavailability and development of muscular disorders both in humans and livestock has been established for a long time. With the development of genomics, the function of several selenoproteins was shown to be involved in muscle activity, including SELENON, which was linked to an inherited form of myopathy. Development of animal models has helped to dissect the physiological dysfunction due to mutation in the SELENON gene; however the molecular activity remains elusive and only recent analysis using both in vivo and in vitro experiment provided hints toward its function in oxidative stress defence and calcium transport control. This review sets out to summarise most recent findings for the importance of selenium in muscle function and the contribution of this information to the design of strategies to cure the diseases.

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Acknowledgments

This work was supported by a grant from the Meyer Foundation to A.L., a Telethon career award (TDEZ00112T), ERC Cariplo (2014-1856) and biomedical science for young scientist Cariplo (2014-1075) to E.Z.

Author information

Authors and Affiliations

  1. Université de Strasbourg, CNRS, Architecture et Réactivité de l’ARN, IBMC-15, Strasbourg, France

    Alain Lescure & Mireille Baltzinger

  2. Dulbecco Telethon Institute at IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

    Ester Zito

Authors
  1. Alain Lescure
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  2. Mireille Baltzinger
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  3. Ester Zito
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Corresponding authors

Correspondence to Alain Lescure or Ester Zito .

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Editors and Affiliations

  1. Research Unit: Analytical BioGeoChemistry, Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Neuherberg, Germany

    Bernhard Michalke

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Lescure, A., Baltzinger, M., Zito, E. (2018). Uncovering the Importance of Selenium in Muscle Disease. In: Michalke, B. (eds) Selenium. Molecular and Integrative Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-319-95390-8_18

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